A5067575399- Congenital Diaphragmatic Hernia Studies
- Congenital gastrointestinal and neural anomalies
- Urological Disorders and Treatments
- Neonatal Respiratory Health Research
- Esophageal and GI Pathology
- Colorectal Cancer Treatments and Studies
- Gastrointestinal disorders and treatments
- Congenital Anomalies and Fetal Surgery
- Tracheal and airway disorders
- Pediatric Urology and Nephrology Studies
- Gastric Cancer Management and Outcomes
- Intestinal Malrotation and Obstruction Disorders
- Sarcoma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
- Anorectal Disease Treatments and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Tumor Research and Treatment
- Urinary and Genital Oncology Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
Juntendo University
2019-2025
Children's Hospital Research Institute of Manitoba
2022-2024
University of Manitoba
2022-2024
Sakai Municipal Hospital
2021-2024
University College London
2022
University College Hospital
2022
Teine Keijinkai Hospital
2021
Tokyo Metropolitan Komagome Hospital
2019
Nagano Children's Hospital
2018
Juntendo University Hospital
2018
There is a clinical need to develop lipid nanoparticles (LNPs) deliver congenital therapies the fetus during pregnancy. The aim of these restore normal fetal development and prevent irreversible conditions after birth. As first step, LNPs be optimized for transplacental transport, safety on placental barrier organs transfection efficiency. We developed characterized library varying compositions used machine learning (ML) models delineate determinants LNP size zeta potential. Utilizing...
Circulating microRNAs (miRNAs) have been reported as a biomarker for human malignancies, including colorectal cancer (CRC). The purpose of this study was to identify novel CRC through examination serum miRNAs from the patients with CRC. Microarray analysis miRNA expression performed using paired pre- and post-operative 10 patients. miR-103 miR-720 decreased significantly in when compared pre-operative serum. With an extended scale validation by qRT-PCR (quantitative real-time polymerase...
Introduction: To evaluate two established soft tissue interposition techniques used during redo surgery for selected post-urethroplasty complications of hypospadias surgery. Material and Methods: Patients with who had scrotal fat, tunica vaginalis fascia, or external spermatic fascia identified from all patients presenting to a single institute treated by surgeon between 2003 2019 (n=217) were reviewed retrospectively. Urethrocutaneous fistula repair minor cosmetic corrections excluded....
Previously, using recombinant human progastrin-releasing peptide (ProGRP)(31-98), we developed a RIA for ProGRP(31-98) and demonstrated that the determination of serum was reliable marker small-cell lung carcinoma (SCLC) (Miyake et al., Cancer Res 1994;54:2136-40). Aiming more convenient assay system, have now evaluated highly sensitive specific ELISA ProGRP(31-98). Only 50 microL nonextracted is needed, results are obtained in only 2 h. Intraassay between-day CVs were 1.7-4.6% 4.2-6.8%,...
This study aimed to analyze circulating tumor cells (CTCs) from patients with colorectal cancer (CRC). We designed a dielectrophoresis-based micropore system and tested its cell capture HT29 colon cells. Then, blood samples were drawn 24 stages II-IV CRC. Mononuclear isolated loaded into the system. Single positioned small pores dielectrophoresis. After labeling appropriate antibodies, tumor-like collected an automated micromanipulator. 43 CTCs 15 out of patient samples. The presence CTC was...
Abnormal lung development is the main cause of morbidity and mortality in neonates with congenital diaphragmatic hernia (CDH), a common birth defect (1:2,500) largely unknown pathobiology. Recent studies discovered that inflammatory processes, specifically NF-κB-associated pathways, are enriched human experimental CDH. However, molecular signaling NF-κB abnormal CDH its potential as therapeutic target require further investigation. Using sections hypoplastic explant cultures from nitrofen...
Abstract Aim Due to the overwhelming spread of SARS‐CoV‐2 and its disruption healthcare system, delays reduced numbers were reported for colorectal cancer screening, colonoscopies, surgery during COVID‐19 pandemic. This multicenter retrospective study investigated still poorly understood impact pandemic on treatment in Japan. Methods was organized by Clinical Study Group Osaka University, which comprised 32 major institutions Osaka. We retrospectively analyzed number surgeries colonoscopies...
This study aimed to identify the risk factors for postoperative complications after laparoscopic low anterior resection treatment of advanced rectal cancers. A prospectively maintained database was retrospectively analyzed. Oncological parameters in resected specimens and clinical complications, including anastomotic leakage, were examined patients with stage II III upper cancer who underwent resection, total mesorectal excision. Pathologic margins negative all patients. Postoperative...
Congenital diaphragmatic hernia (CDH) is characterized by incomplete closure of the diaphragm. While ensuing compression to fetal lung causes hypoplasia, specific cellular phenotypes and developmental signaling defects in alveolar epithelium CDH are not fully understood. Employing samples from human CDH, a surgical lamb model nitrogen rat model, we investigate whether impairs epithelial differentiation Yes-associated protein (YAP)-mediated mechanosensing. We showed that humans lambs caused...
Primary hepatic angiosarcoma is a rare type of tumor with poor prognosis. To the best our knowledge, curative surgery metastatic gastrointestinal from has not been reported previously. In present report, case colonic metastasis primary discussed. A rapidly growing mass was identified in liver an 84‑year‑old Japanese male who underwent subsegmentectomy liver. Microscopic examination determined that composed sheets spindle cells. Immunohistochemical studies confirmed diagnosis positive CD31...