A5020059646- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Cancer Cells and Metastasis
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Cancer Research and Treatments
- Inflammatory Bowel Disease
- Anorectal Disease Treatments and Outcomes
- Calcium signaling and nucleotide metabolism
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Genomics and Diagnostics
- Cellular transport and secretion
- Colorectal Cancer Screening and Detection
- Cancer, Lipids, and Metabolism
- Photodynamic Therapy Research Studies
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Stoma care and complications
- Esophageal Cancer Research and Treatment
Osaka University
2014-2025
Osaka International Cancer Institute
2017-2025
Osaka Medical Center for Cancer and Cardiovascular Diseases
1983-2021
Center for Cancer Research
2016
Massachusetts General Hospital
2016
Obayashi (Japan)
2016
Harvard University
2015
Osaka Hospital
2006
Abstract Tyrosine kinase inhibitors are effective treatments for non-small-cell lung cancers (NSCLCs) with epidermal growth factor receptor ( EGFR ) mutations. However, relapse typically occurs after an average of 1 year continuous treatment. A fundamental histological transformation from NSCLC to small-cell cancer (SCLC) is observed in a subset the resistant cancers, but molecular changes associated this remain unknown. Analysis tumour samples and cell lines derived mutant patients revealed...
A new genus, Sphingobacterium, two combinations, Sphingobacterium spiritivorum (Holmes, Owen, and Hollis) multivorum Weaver), species, mizutae Flavobacterium indologenes, are described. The genus is characterized distinguished from the by presence in its strains of high concentrations sphingophospholipids as cellular lipid components. S. designated type species Sphingobacterium. ATCC 33299 (= GIFU 1203) F. indologenes 29893 CDC 3716 = 1347 NCTC 10796 RH 542) species. Emended descriptions presented.
Although cancer is a disease with genetic and epigenetic origins, the possible effects of reprogramming by defined factors remain to be fully understood. We studied induction or inhibition cancer-related genes immature status-related whose alterations have been reported in gastrointestinal cells. Retroviral-mediated introduction induced pluripotent stem (iPS) cell was necessary for inducing expression proteins, including Nanog, Ssea4, Tra-1-60, Tra-1-80 esophageal, stomach, colorectal,...
// Yujiro Nishizawa 1, 2, * , Masamitsu Konno 3, Ayumu Asai 3 Jun Koseki Koichi Kawamoto 2 Norikatsu Miyoshi 1 Hidekazu Takahashi Naohiro Nishida Naotsugu Haraguchi Daisuke Sakai Toshihiro Kudo Taishi Hata Chu Matsuda Tsunekazu Mizushima 4 Taroh Satoh Yuichiro Doki Masaki Mori and Hideshi Ishii Department of Gastroenterological Surgery, Graduate School Medicine, Osaka University, Suita, Osaka, Japan Frontier Science for Cancer Chemotherapy, Disease Data Science, Therapeutics Inflammatory...
Abstract Malnutrition has been considered to be associated with the prognosis of cancer. The Geriatric Nutritional Risk Index (GNRI), based on serum albumin levels, present body weight, and ideal is a simple screening tool predict risk nutrition-related morbidity mortality in elderly patients. We aimed evaluate whether preoperative GNRI was postoperative complications patients colorectal cancer (CRC). retrospectively enrolled 313 CRC aged ≥65 years after curative surgery classified them into...
Sox2 is known as the undifferentiated cell marker. Recent studies have shown that may also be involved in maintenance of cancer stem cells (CSCs) skin and bladder cancers. In this study, we aimed to clarify role colorectal CSCs. expression was measured colon clinical samples by qRT-PCR western blot analysis. To visualize active mRNA production, generated a promoter-dependent DsRed fluorescence emission system. Colon lines tumor tissues generally expressed protein. Knockdown siRNA led...
Given that cancer stem cells (CSC) play a key role in drug resistance and relapse, targeting CSCs remains promising therapy. Here we show RAB5/7, which are involved the endolysosomal pathway, roles maintenance of CSC survival via regulation mitophagic pathway. Inhibition RAB5/7 efficiently eliminated colorectal disrupted foci. In addition, identified mefloquine hydrochloride, an antimalarial drug, as novel inhibitor CSC-targeting drug. Endolysosomal LAMP1/2 mediated parkin-dependent...
Abstract Background Tissue-resident memory T (Trm) cells are associated with cytotoxicity not only in viral infection and autoimmune disease pathologies but also many cancers. Tumour-infiltrating CD103 + Trm predominantly comprise CD8 that express cytotoxic activation immune checkpoint molecules called exhausted markers. This study aimed to investigate the role of colorectal cancer (CRC) characterise cancer-specific Trm. Methods Immunochemical staining anti-CD8 anti-CD103 antibodies for...
TRIB3 is a human homologue of Drosophila tribbles. Previous studies have shown that controls the cell growth through ubiquitination-dependent degradation other proteins, whereas its significance in prognosis colorectal cancer (CRC) not yet fully understood. This study comprised 202 patients who underwent surgery for CRC, as well 22 lines derived from gastrointestinal cancer. The correlation gene expression with clinical parameters was assessed. biological evaluated by knockdown experiments...
High-output syndrome (HOS) is a complication of ileostomy, which can affect quality life significantly; however, its exact cause remains unknown. The aim this study was to establish the frequency, as well preoperative and intraoperative factors predictive HOS. subjects were 164 consecutive patients who underwent colorectal cancer surgery with ileostomy construction at our institute between January, 2011 August, 2018. Thirteen postoperative complications reported causes HOS, including...
It is important to establish cancer stem cell (CSC)-targeted therapies eradicate cancer. As it a CSC marker, we focused on Kruppel-like factor 5 (KLF5) in this study.We searched for candidate microRNAs (miRNAs) that inhibited KLF5 expression by silico analyses and screened them colon lines.We identified one promising miRNA, miR-4711-5p, downregulated direct binding. This miRNA suppressed proliferation, migration invasion ability, as well stemness, including decreased marker expression,...
Innate lymphoid cells (ILC) are responsible for mucosal tissue homeostasis and involved in the progression suppression of several types cancer. However, effects ILCs on colorectal cancer poorly understood. We characterized human normal colon tissue, investigating their role tumor immune microenvironment. Normal mucosa tissues were obtained from patients with cancer, isolated by enzymatic digestion. NKp44+ ILC3s high expression tertiary structure (TLS) formation-related genes, including LTA,...
Background/Objectives: Liquid biopsy methods have gained prominence as minimally invasive tools to improve cancer treatment outcomes. Circulating tumor cells (CTCs) offer valuable insights into both primary and metastatic lesions. However, validating the CTC test results requires confirmation that detected originate from tissue. While studies identified CTCs in colorectal (CRC) patients using molecular markers, simultaneous validation of their tissue origin remains unexplored. Methods: This...
Abstract Background Enteric glial cells (EGCs) have traditionally been regarded as supportive within the enteric nervous system. However, recent studies indicate that, beyond their involvement in neural circuit formation, EGCs possess antigen-presenting capabilities and actively contribute to mucosal defense. In mouse myenteric plexus, inflammation-inducing stimuli shown trigger expression of MHC class II on cells, which subsequently influences differentiation helper T-cell regulatory...
Reversing Hartmann's procedure is complicated owing to dense adhesions resulting from inflammation in the pelvic region. These pose challenges identifying rectum and increase risk of organ injuries. We propose a technique lift fix rectal stump abdominal wall diminish facilitate identification stump. The patient underwent for generalized peritonitis perforation sigmoid colon. cavity was significantly contaminated with fecal ascites, postoperative were anticipated. Therefore, lifted. outcomes...
Abstract Aim There has been no prospective multicentre validation of the treatment outcomes minimally invasive lateral pelvic lymph node dissection for lower rectal cancer; hence, this study aimed to evaluate prophylactic laparoscopic dissection. Method Between May 2018 and August 2021, 90 patients with Stage II–III cancer were registered. The clearance range included nodes around internal iliac artery obturator nodes, while autonomic nerves generally preserved. primary outcome was incidence...