A5013707381- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Gastric Cancer Management and Outcomes
- Inflammatory Bowel Disease
- Cancer Immunotherapy and Biomarkers
- Eosinophilic Esophagitis
- Diverticular Disease and Complications
- Biliary and Gastrointestinal Fistulas
- Gallbladder and Bile Duct Disorders
- Colorectal and Anal Carcinomas
- Galectins and Cancer Biology
- Colorectal Cancer Surgical Treatments
- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Treatments and Studies
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Cerebrovascular and Carotid Artery Diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Multiple Myeloma Research and Treatments
- Gastrointestinal disorders and treatments
- Aortic aneurysm repair treatments
- Protein Degradation and Inhibitors
- Peripheral Artery Disease Management
Charité - Universitätsmedizin Berlin
2025
Osaka University
2017-2022
Toyonaka Municipal Hospital
2015
T cells differentiate into highly diverse subsets and display plasticity depending on the environment. Although lymphocytes are key mediators of inflammation, functional specialization in inflammatory bowel disease (IBD) has not been effectively described. Here, we performed deep profiling intestinal mucosa IBD identified a CD4 + tissue-resident memory cell (Trm) subset that is increased Crohn’s (CD) showing unique properties. Functionally transcriptionally distinct Trm observed inflamed gut...
Innate lymphoid cells (ILC) are responsible for mucosal tissue homeostasis and involved in the progression suppression of several types cancer. However, effects ILCs on colorectal cancer poorly understood. We characterized human normal colon tissue, investigating their role tumor immune microenvironment. Normal mucosa tissues were obtained from patients with cancer, isolated by enzymatic digestion. NKp44+ ILC3s high expression tertiary structure (TLS) formation-related genes, including LTA,...
Cancer-specific cell surface antigens are ideal therapeutic targets for monoclonal antibody (mAb)–based therapy. Here, we report that multiple myeloma (MM), an incurable hematological malignancy, can be specifically targeted by mAb recognizes a ubiquitously present protein, CD98 heavy chain (hc) (also known as SLC3A2). We screened more than 10,000 clones raised against MM cells and identified R8H283, bound but not normal hematopoietic or nonhematopoietic cells. R8H283 recognized CD98hc. did...
Creeping fat is a characteristic of Crohn's disease and impacts the course. We evaluated creeping formation, focusing on innate lymphoid cell-mediated fibrogenesis its clinical significance. Patients with inflammatory lesions in ileum (the most commonly affected area), who underwent surgical resection at Osaka University or Hyogo Medical (n = 34), were included. The mesentery obtained from three sites: control, non-creeping part, part. distribution properties cells analyzed by cell...
Abstract Background Preoperative 5-FU-based chemoradiation is currently a standard treatment for advanced rectal cancer, particularly in Western countries. Although it reduced the local recurrence, could not necessarily improve overall survival. Furthermore, can also produce adverse effects and long-term sphincter function deficiency. Adjuvant oxaliplatin plus capecitabine (XELOX) recommended regimen patients with curatively resected colon cancer. However, efficacy of postoperative adjuvant...
Background/Aims: Endoscopic recurrence (ER) after intestinal resection for Crohn’s disease (CD) precedes the clinical recurrence, and severity of ER correlates with subsequent recurrence. This study aimed to identify risk factors related early CD create a prediction model. Methods: The patients who underwent between April 2008 2017 took endoscopic evaluation 6 12 months surgery were retrospectively analyzed. Results: A total 15 out 52 (29%) developed ER. univariate analysis demonstrated that...
Abstract A 69‐year‐old woman with focal infrarenal aortic stenosis was diagnosed rectosigmoid cancer. Because radical resection for colon cancer required dissection of vessels that supplied blood flow to the legs, revascularization by stent placement performed before colectomy. We subsequently laparoscopic low anterior without any complications. Two and a half years after colectomy, however, patient developed colonic ischemia due thrombosis dilated marginal artery served as collateral...
患者は41歳，女性．腹痛・嘔吐を主訴に当院を受診し，腹部CT検査にて気腫性胆嚢炎と診断された．臓器障害は伴わず中等症急性胆嚢炎に分類され，受診翌日に腹腔鏡下胆嚢摘出術を施行した．胆嚢壁は壊死しており，肝床部や大網との高度の癒着を認めたが，安全に腹腔鏡下手術を施行しえた．術後合併症なく第7病日に退院となった．気腫性胆嚢炎は中等症急性胆嚢炎の重篤な局所合併症の一つとされ，緊急手術の適応とされている．しかし，その手術手技の困難性から開腹術と腹腔鏡下手術とのいずれを選択すべきかについて一定の見解は得られていない．腹腔鏡下胆嚢摘出術にて安全に治療しえた気腫性胆嚢炎の1例を経験したので報告する．
<div>Abstract<p>Innate lymphoid cells (ILC) are responsible for mucosal tissue homeostasis and involved in the progression suppression of several types cancer. However, effects ILCs on colorectal cancer poorly understood. We characterized human normal colon tissue, investigating their role tumor immune microenvironment. Normal mucosa tissues were obtained from patients with cancer, isolated by enzymatic digestion. NKp44<sup>+</sup> ILC3s high expression tertiary...
<p>Supplementary figures S1-7</p>
<p>Supplementary figures S1-7</p>
<div>Abstract<p>Innate lymphoid cells (ILC) are responsible for mucosal tissue homeostasis and involved in the progression suppression of several types cancer. However, effects ILCs on colorectal cancer poorly understood. We characterized human normal colon tissue, investigating their role tumor immune microenvironment. Normal mucosa tissues were obtained from patients with cancer, isolated by enzymatic digestion. NKp44<sup>+</sup> ILC3s high expression tertiary...
Most patients with Crohn’s disease (CD) that undergo intestinal resection will subsequently experience recurrence. Endoscopic recurrence (ER) after for CD precedes the clinical recurrence, and its severity correlates subsequent severity. It is important clinicians to understand monitor at high risk of strengthen drug therapy, when necessary. The study aimed identify factors related early ER create a prediction model. who underwent anastomosis between April 2008 2017 took endoscopic...
e16039 Background: Preoperative 5-FU-based chemoradiation is currently a standard treatment for advanced rectal cancer, particularly in Western countries. Although it reduced the local recurrence, could not necessarily improve overall survival. Furthermore, can also produce adverse effects and long-term sphincter function deficiency. Adjuvant oxaliplatin plus capecitabine (XELOX) recommended regimen patients with curatively resected colon cancer. However, efficacy of postoperative adjuvant...