A5061315332- Gastric Cancer Management and Outcomes
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Esophageal and GI Pathology
- Immune Cell Function and Interaction
- Venous Thromboembolism Diagnosis and Management
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Nutrition and Health in Aging
- Colorectal Cancer Screening and Detection
- Single-cell and spatial transcriptomics
- Anesthesia and Pain Management
- Pain Management and Opioid Use
- Viral-associated cancers and disorders
- Extracellular vesicles in disease
- Pelvic and Acetabular Injuries
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Telomeres, Telomerase, and Senescence
Osaka International Cancer Institute
2023-2025
Yahoo (United Kingdom)
2024
Osaka University
2020-2024
Osaka National Hospital
2016-2021
Abstract Background Tissue-resident memory T (Trm) cells are associated with cytotoxicity not only in viral infection and autoimmune disease pathologies but also many cancers. Tumour-infiltrating CD103 + Trm predominantly comprise CD8 that express cytotoxic activation immune checkpoint molecules called exhausted markers. This study aimed to investigate the role of colorectal cancer (CRC) characterise cancer-specific Trm. Methods Immunochemical staining anti-CD8 anti-CD103 antibodies for...
Single-cell RNA sequencing (scRNAseq) has been used to assess the intra-tumor heterogeneity and microenvironment of pancreatic ductal adenocarcinoma (PDAC). However, previous knowledge is not fully universalized. Here, we built a single cell atlas PDAC from six datasets containing over 70 samples >130,000 cells, demonstrated its application reanalysis bulk transcriptomic cohorts inferring cell-cell communications. The decomposition transcriptomics using scRNAseq data showed cellular PDAC;...
Abstract The GLOW and SPOTLIGHT trials have demonstrated the efficacy of chemotherapy plus zolbetuximab for HER2-negative, claudin-18 isoform 2 (CLDN18.2)–positive unresectable advanced or recurrent gastric cancer (AGC)/gastroesophageal junction cancer. However, data on adverse events in real-world clinical practice are still insufficient. Specifically, gastritis protein-losing enteropathy (PLE), which were not evident either trials, generally recognized. This paper reports notable course...
<title>Abstract</title> <bold>Background:</bold> Stage IV gastric cancer remains challenging to treat despite recent advances in systemic therapy. Among patients with favorable responses chemotherapy, conversion surgery aiming for R0 resection has shown promise improving survival. Immune checkpoint inhibitors (ICIs) have become a key component of treatment, but their prognostic impact the setting unclear. <bold>Methods:</bold> This retrospective single-center study included 98 who underwent...
Endoscopic resection is typically performed for early T1 stage colorectal cancer (T1 CRC). Additional surgery subsequently recommended based on pathological findings; however, the current criteria may result in overtreatment. The present study aimed to re-examine reported risk factors lymph node (LN) metastasis CRC and develop a prediction model using large multi-institutional dataset. In this retrospective study, medical records of 1,185 patients with who underwent between January 2008...
BACKGROUND: Local recurrence is common after curative resection for rectal cancer. Although one expects radical of locally recurrent cancer to be curative, the postoperative re-recurrence rate relatively high. Therefore, identifying risk factors may improve prognosis with early therapeutic intervention. OBJECTIVE: We evaluated relationship between perioperative serum CEA/CA19-9 levels and in validate their usefulness surveillance DESIGN: This was a single-center retrospective cohort study....
Background/Aim: CheckMate 577 evaluated adjuvant nivolumab therapy after neoadjuvant chemoradiotherapy and surgery for esophageal cancers. However, the efficacy of this treatment in patients who received chemotherapy remains unknown. This study investigated short-term outcomes with advanced squamous cell carcinoma post-neoadjuvant chemotherapy. Patients Methods: Out 956 thoracic cancer underwent radical esophagectomy, 227 exhibited ypN1-3 were included study. Results: Among patients, 30 197...
Local recurrence is common after curative resections for rectal cancer. Surgical intervention among the best treatment choices. However, achieving a negative resection margin often requires extensive pelvic organ resections; thus, postoperative complication rate quite high. Recent studies have reported that inflammatory index could predict complications. This study aimed to validate correlation between clinical factors, including markers, and severe complications surgery local recurrent...
Background/Aim: The enhanced recovery after surgery (ERAS) program is expected to improve perioperative outcomes in patients with esophageal cancer. However, how ERAS impacts the postoperative body composition and factors related compliance rate of have not been fully investigated. Patients Methods: study included 252 consecutive thoracic cancer who underwent minimally invasive esophagectomy. We compared including between old new one that aimed shorten length stay (LOS). Compliance-related...
Pembrolizumab plus chemotherapy has been indicated as the first-line treatment for metastatic or unresectable locally advanced esophageal cancer. However, pretreatment biomarkers predicting clinical outcomes remain unclear. We investigated predictive value of inflammation-based prognostic scores in patients treated with pembrolizumab and chemotherapy. The Prognostic Nutritional Index (PNI), C-reactive protein/albumin ratio (CAR), neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR)...
Approximately 10% of patients with colorectal cancer submucosal invasion have lymph node metastasis. Pathological risk factors for metastasis varying sensitivities and specificities. To predict the metastasis, identification new is vital. Tumor-infiltrating T cells been reported to improve prognosis many solid tumors. Therefore, purpose this study was examine relationship between tumor-infiltrating in invasion. We examined CD8+ level as a factor Using immunohistochemical staining, we...
Castleman's disease (CD) is a rare atypical lymphoproliferation disorder first reported in 1954. Clinically, CD classified as unicentric or multicentric based on anatomical distribution. Unicentric primarily affects the mediastinum, and rarely retroperitoneal location. The standard treatment for complete surgical resection; however, this can be complicated by high degree of attachment with other organs hypervascularity. Preoperative angiography embolization arteries that feed problematic...
The cornerstone of treating colorectal cancer (CRC) is generally a surgical resection with lymph node (LN) dissection. tools for predicting metastasis (LNM) in submucosal (SM) CRC are useful to avoid unnecessary resection.Retrospectively, we analyzed 526 consecutive patients SM who underwent at the Osaka International Cancer Institute, University Hospital, and Minoh City Japan, between 1984 2012. Institute group Hospital were randomly divided into training set test 2:1. prediction model was...
Background/Aim: Postoperative venous thromboembolism (VTE) is a well-recognized complication that leads to morbidity and mortality. Lateral lymph node dissection (LLND) for rectal cancer thought potentially increase the risk of VTE due its technical complexity. However, relationship between LLND remains inadequately understood. The aim this study was elucidate impact on incidence postoperative VTE. Patients Methods: This retrospective analysis patients who underwent resection 2010 2018...
<title>Abstract</title> Background The clinical significance of the lymph node ratio (LNR), number metastatic nodes per dissected node, has not been sufficiently clarified in ampullary cancer. Methods Among patients diagnosed histopathologically with cancer between 1980 and 2018, study included 106 who underwent pathological radical resection by pancreaticoduodenectomy. relationships LNR sites prognosis were examined. Results Multivariate analysis revealed that sex metastasis independent...
<title>Abstract</title> Background Local recurrence is common after curative resections of rectal cancer. Surgical resection considered a primary treatment option for patients with locally recurrent cancer (LRRC). LRRC often requires combined other organs, especially in the case posterior recurrence, which sacrum, making surgery highly invasive. Venous thromboembolism (VTE) one lethal complications postoperative period, particularly field pelvic surgery. We found no reports regarding risks...
Local recurrence is common after curative resections of rectal cancer. Surgical resection considered a primary treatment option for patients with locally recurrent cancer (LRRC). LRRC often requires combined other organs, especially in the case posterior recurrence, which sacrum, making surgery highly invasive. Venous thromboembolism (VTE) one lethal complications postoperative period, particularly field pelvic surgery. We found no reports regarding risks VTE LRRC, typical invasive procedure...