A5101420044- Geological and Geochemical Analysis
- Nuclear reactor physics and engineering
- Nuclear Physics and Applications
- TGF-β signaling in diseases
- Cancer Cells and Metastasis
- Pluripotent Stem Cells Research
- High-pressure geophysics and materials
- Monoclonal and Polyclonal Antibodies Research
- Particle physics theoretical and experimental studies
- Particle Detector Development and Performance
- Nuclear Materials and Properties
- Reproductive Biology and Fertility
- Geochemistry and Geologic Mapping
- CRISPR and Genetic Engineering
- Muscle activation and electromyography studies
- 3D Printing in Biomedical Research
- Animal Genetics and Reproduction
- Cancer, Hypoxia, and Metabolism
- Engineering Applied Research
- Robotic Path Planning Algorithms
- Hepatitis B Virus Studies
- Neural Networks and Reservoir Computing
- Aerospace Engineering and Energy Systems
- HER2/EGFR in Cancer Research
- Genomics and Chromatin Dynamics
University of Tsukuba
2009-2025
Asahikawa Medical University
2021-2025
Tokyo Medical and Dental University
2017-2024
Oita University
2024
Tokyo Institute of Technology
1991-2024
The University of Tokyo
2019-2024
University of California, Davis
2017-2024
Waseda University
2014-2024
The Memory Clinic
2024
University of Fukui
2023-2024
Abstract The tumor microenvironment (TME) consists of various components including cancer cells, vessels, cancer‐associated fibroblasts (CAFs), and inflammatory cells. These interact with each other via cytokines, which often induce progression. Thus, a greater understanding TME networks is crucial for the development novel therapies. Many types express high levels TGF‐β, induces endothelial‐to‐mesenchymal transition (EndMT), leading to formation CAFs. Although we previously reported that...
Abstract Magnetic refrigeration technology can achieve higher energy efficiency based on the magnetocaloric effect (MCE). However, practical application of MCE materials is hindered by their poor mechanical properties, making them challenging to process into devices. Conventional strengthening strategies usually lead a trade‐off with capacity reduction. Here, novel design presented overcome this dilemma forming dual‐phase alloys through in situ precipitation tough magnetic phase within an...
During mild replication stress provoked by low dose aphidicolin (APH) treatment, the key Fanconi anemia protein FANCD2 accumulates on common fragile sites, observed as sister foci, and protects genome stability. To gain further insights into function its regulatory mechanisms, we examined genome-wide chromatin localization of in this setting ChIP-seq analysis. We found that mostly central regions a set large transcribed genes were extensively overlapped with known CFS. Consistent previous...
A proton-conducting coordination polymer glass derived from a protic ionic liquid works as moldable solid electrolyte and the anhydrous fuel cell showed<italic>I</italic>–<italic>V</italic>performance of 0.15 W cm<sup>−2</sup>at 120 °C.
Cell-cell interaction factors that facilitate the progression of adenoma to sporadic colorectal cancer (CRC) remain unclear, thereby hindering patient survival.
The functions of POU class 5 transcription factor 1 (Oct-4) and caudal-type homeobox 2 (Cdx2) in the differentiation murine inner cell mass (ICM) trophectoderm (TE) have been described detail. However, little is known about roles OCT-4 CDX2 preimplantation bovine embryos. To elucidate their during early development embryos, we performed downregulation using RNA interference. We injected OCT-4- or CDX2-specific short interfering RNAs (siRNAs) into zygotes. rate blastocyst OCT-4-downregulated...
Abstract Malignant melanoma is one of the untreatable cancers in which conventional therapeutic strategies, including chemotherapy, are hardly effective. Therefore, identification novel targets involved progression urgently needed for developing effective methods. Overexpression interleukin-13 receptor α2 (IL13Rα2) observed several cancer types glioma and pancreatic cancer. Although IL13Rα2 implicated various cancer, its expression roles malignant have not yet been elucidated. In present...
The hepatitis B virus (Hepadnaviridae) induces chronic and hepatic cancer in humans. A novel domestic cat hepadnavirus (DCH) was recently identified several countries, however, the DCH infection status of cats Japan is unknown. Therefore, we investigated rate 139 samples collected Japan. We one positive blood sample (0.78%) from a 17-year-old female with chronically elevated alanine aminotransferase. Phylogenetic analysis demonstrated that strain this study genetically different strains...
We developed a single-molecule enzyme activity assay platform for NAD(P)+-dependent oxidoreductases, leveraging new NAD(P)H-responsive fluorogenic probe optimized microdevice-based fluorometric detection. This enabled the detection of activities in blood and cerebrospinal fluid (CSF), including lactate dehydrogenase, glucose-6-phosphate hexokinases. demonstrate its potential activity-based diagnosis by detecting altered populations species CSF from liver damage brain tumor patients.
Acute lower extremity limb ischemia (ALI) is a common vascular surgery emergency, primarily caused by embolism or atherosclerotic in situ thrombosis-acute on chronic (AoCLI). This study aimed to examine the clinical features and treatment challenges of AoCLI. Between January 2014 December 2022, 73 patients with AoCLI (n=35) embolic ALI (n=38) were analyzed. The time from onset was significantly longer (P<0.01), rate contralateral diseases higher than (P<0.01). Treatment intraoperative...
Abstract Histotripsy is a non-invasive treatment method that mechanically destroys soft tissues using cavitation bubbles generated by high-intensity focused ultrasound (HIFU) sonication. Our previous study suggested scanning the HIFU focus in opposite direction of propagation could improve time efficiency shock scattering histotripsy. In this paper, we extend increasing number and experimentally investigate dependence on pulse repetition frequency (PRF) The results showed energy at high PRF...
Efficient use of seed nutrient reserves is crucial for germination and establishment plant seedlings. Mobilizing oil in Arabidopsis involves β-oxidation, the glyoxylate cycle, gluconeogenesis, which provide essential energy carbon skeletons needed to sustain seedling growth until photoautotrophy acquired. We demonstrated that H+-PPase activity required gluconeogenesis. Lack fugu5 mutants increases cytosolic pyrophosphate (PPi) levels, partially reduces sucrose synthesis de novo inhibits cell...
Tumor progression is governed by various growth factors and cytokines in the tumor microenvironment (TME). Among these, transforming factor-β (TGF-β) secreted cell types residing TME promotes inducing epithelial-to-mesenchymal transition (EMT) of cancer cells angiogenesis. TGF-β comprises three isoforms, TGF-β1, -β2, -β3, transduces intracellular signals via type I receptor (TβRI) II (TβRII). For purpose designing ligand traps that reduce oncogenic signaling TME, chimeric proteins comprising...
Transforming growth factor β (TGF-β) increases epithelial cancer cell migration and metastasis by inducing epithelial-mesenchymal transition (EMT). TGF-β also inhibits proliferation G1 phase cell-cycle arrest. However, the correlation between these tumor-promoting -suppressing effects remains unclear. Here, we show that confers higher motility metastatic ability to oral cells in phase. Mechanistically, keratin-associated protein 2-3 (KRTAP2-3) is a regulator of dual TGF-β, its expression...
To reveal the logic of size regulation in multicellular organisms, we have used Arabidopsis thaliana as a model organism and its leaves organ. We discovered existence compensatory system, whereby decrease leaf cell number often triggers unusual enlargement. However, despite large compensation-exhibiting mutants analyzed to date, only limited understanding detailed molecular mechanisms triggering subsequent compensated enlargement (CCE). CCE fugu5, vacuolar type H+-pyrophosphatase...
The substantial epigenetic remodeling that occurs during early stages of mammalian embryonic development likely contributes to reprogramming the parental genomes from a differentiated totipotent state and activation genome. Trimethylation lysine 27 histone 3 (H3K27me3) is repressive mark undergoes global dynamic changes preimplantation several species. To ascertain role H3K27me3 in bovine we perturbed activity KDM6B, which demethylates H3K27me3. Knockdown maternal KDM6B mRNA inhibited...
Network structures of glasses are essential to understanding their bulk mechanical and functional properties. Despite growing interests in coordination polymer (CP) metal–organic framework (MOF) glasses, the macromolecular tuning networks (CN) CP/MOF remains unexplored. Here, we propose use CN size CP investigate network-dependent viscoelastic properties proton (H+) conductivities. Structural analysis having different ratios Zn/HnPO4 (1:3, 0.875:3, 0.75:3) exhibits ratio-dependent sizes....
Abstract Rapid advancements in electronic devices yield an urgent demand for high‐performance packaging materials with high thermal conductivity, low expansion, and great mechanical properties. However, it is a challenge current design philosophies to fulfill all the requirements simultaneously. Here, effective strategy proposed significantly promoting conductivity machinability of negative expansion alloy (Zr,Nb)Fe 2 through eutectic precipitation copper networks. The dual‐phase exhibits...
Transcription factor TEA domain family transcription 4 (Tead4) is one of the key factors involved in differentiation trophectoderm (TE) murine embryos. However, knowledge on roles TEAD4 preimplantation development during bovine embryos currently limited. This study examined transcript and protein expression patterns attempted to elucidate functions using RNA interference. mRNA was found be upregulated between 16-cell morula stages, nuclear localization detected at stage, as well subsequent...