A5101605212- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Cell death mechanisms and regulation
- Ferroptosis and cancer prognosis
- Fungal and yeast genetics research
- Chemotherapy-induced cardiotoxicity and mitigation
- Genomics and Chromatin Dynamics
- Cellular transport and secretion
- FOXO transcription factor regulation
- Signaling Pathways in Disease
- RNA Research and Splicing
- Glycosylation and Glycoproteins Research
- Telemedicine and Telehealth Implementation
- Galectins and Cancer Biology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Extracellular vesicles in disease
- Nitric Oxide and Endothelin Effects
- Cancer, Lipids, and Metabolism
- Melanoma and MAPK Pathways
- Aortic Disease and Treatment Approaches
- Reproductive Biology and Fertility
Affiliated Hospital of Qingdao University
2015-2024
Qingdao University
2015-2024
University of Massachusetts Chan Medical School
2018
University of California, Davis
2017
University of Massachusetts Amherst
2015
The University of Texas Southwestern Medical Center
1997-2000
Southwestern Medical Center
2000
Non-coding RNAs (ncRNAs) are considered major players in physiological and pathological processes based on their versatile regulatory roles different diseases including cardiovascular disease. Circular (circRNAs), a newly discovered class of RNAs, constitute substantial fraction the mammalian transcriptome abundantly expressed system. However, functions these circRNAs ischemic cardiac disease remain largely unknown. Here, we investigated role circRNA transcribed from sodium/calcium exchanger...
Necrosis is a key factor in myocardial injury during cardiac pathological processes, such as infarction (MI), ischemia/reperfusion (I/R) and heart failure. Increasing evidence suggests that several aspects of necrosis are programmed tightly regulated, so targeting the process has become new trend for protection. Multiple cellular signaling pathways have been implicated necrotic cell death, death receptor-mediated extrinsic mitochondrial intrinsic pathways. However, precise mechanisms...
Aims: Cardiomyocyte death critically contributes to the pathogenesis of cardiac disorders, such as myocardial infarction, heart failure, and ischemia/reperfusion (I/R) injury. As one main forms cell death, necrosis plays a critical role in diseases. Multiple signaling pathways have been demonstrated, which receptors, receptor-interacting serine/threonine-protein 1 3 kinases, cyclophilin-D (CypD) deeply implicated. However, fundamental mechanism underlying necroptosis, especially...
Abstract MicroRNA (miR)‐9 plays different roles in cancer types. Here, we investigated the role of miR‐9 non‐small‐cell lung ( NSCLC ) cell invasion and adhesion vitro explored whether was involved transforming growth factor‐beta 1 TGF ‐β1)‐induced by targeting SOX 7. The expression 7 human tissues lines examined reverse transcription‐quantitative polymerase chain reaction. Gain‐of‐function loss‐of‐function experiments were performed on A549 HCC 827 cells to investigate effect presence or...
Doxorubicin (DOX) is a broad-spectrum anti-tumor drug, but its cardiotoxicity limits clinical application. A better understanding of the molecular mechanisms underlying DOX will benefit practice and remedy heart failure. Our present study observed that caused cardiomyocyte (H9c2) apoptosis via induction abnormal mitochondrial fission. Notably, expression levels p21 increased in DOX-treated cardiomyocytes, silencing using siRNA greatly attenuated fission cardiomyocytes. We also found...
Cardiovascular disease is the major cause of death in patients with diabetes. Current treatment strategies for diabetes rely on lifestyle changes and glucose control to prevent angiopathy organ failure. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, used as an add-on therapy insulin treatment. Exenatide also has multiple beneficial effects addition its hypoglycemic effects, such preventing hepatic steatosis protecting against cardiac injury from doxorubicin-induced...
Synaptotagmins bind clathrin AP-2 with high affinity via their second C<sub>2</sub> domain, which indicates they are involved in coated pit function. We now report that expression of synaptotagmins lacking either the domain or entire cytoplasmic region potently inhibit endocytosis. Inhibition was dependent on two intramembrane cysteine residues were found to be essential for synaptotagmin oligomerization. Cells expressing wild-type, but not mutant, truncated fragment had a reduced number...
The substantial epigenetic remodeling that occurs during early stages of mammalian embryonic development likely contributes to reprogramming the parental genomes from a differentiated totipotent state and activation genome. Trimethylation lysine 27 histone 3 (H3K27me3) is repressive mark undergoes global dynamic changes preimplantation several species. To ascertain role H3K27me3 in bovine we perturbed activity KDM6B, which demethylates H3K27me3. Knockdown maternal KDM6B mRNA inhibited...
Pre-B-cell leukemia transcription factor (PBX) proteins have important roles in the development of numerous organs. To date, four members PBX family been identified to be involved human cancer but little is known about their expression patterns and precise functions breast (BC) progression. The aim present study was determine whether they potential prognostic biomarkers patients with BC. PBXs were evaluated using Oncomine, Cancer Cell Line Encyclopedia Gene expression‑based Outcome for...
Myocardial cell death is the hallmark of myocardial infarction. In process injury, platelets contribute to pathogenesis by triggering intense inflammatory responses. Yet, it still unclear if regulate cardiomyocyte directly, thereby exacerbating injury in infarction.We describe a mechanism underlying correlative association between accumulation and using infarction mouse model patient specimens.Myocardial induces internalization, resulting release miR-223-3p, platelet-enriched miRNA. By...
S-adenosylmethionine (SAM) is a donor which provides the methyl groups for histone or nucleic acid modification and phosphatidylcholine production. SAM hypothesized to link metabolism chromatin modification, however, its role in acute gene regulation poorly understood. We recently found that Caenorhabditis elegans with reduced had deficiencies H3K4 trimethylation (H3K4me3) at pathogen-response genes, decreasing their expression limiting pathogen resistance. may be generally required...