A5108059726- Autophagy in Disease and Therapy
- Sports Performance and Training
- Sports Dynamics and Biomechanics
- Circular RNAs in diseases
- Adipose Tissue and Metabolism
- Sports Analytics and Performance
- Mitochondrial Function and Pathology
- RNA modifications and cancer
- Parkinson's Disease Mechanisms and Treatments
- Cardiac electrophysiology and arrhythmias
- Chemotherapy-induced cardiotoxicity and mitigation
- Flavonoids in Medical Research
- Endoplasmic Reticulum Stress and Disease
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Sports injuries and prevention
- Liver Disease Diagnosis and Treatment
- Extracellular vesicles in disease
- Sport Psychology and Performance
- Fatty Acid Research and Health
- Blood Coagulation and Thrombosis Mechanisms
- Phagocytosis and Immune Regulation
- Cell death mechanisms and regulation
- Cardiac Ischemia and Reperfusion
- Cardiovascular Disease and Adiposity
Guangzhou University of Chinese Medicine
2025
Hainan General Hospital
2025
Qingdao University
2018-2024
Second Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
Air Force Medical University
2024
Sichuan University
2023
West China Hospital of Sichuan University
2023
China Institute of Sport Science
2007-2022
Affiliated Hospital of Qingdao University
2020-2022
Necrosis is a key factor in myocardial injury during cardiac pathological processes, such as infarction (MI), ischemia/reperfusion (I/R) and heart failure. Increasing evidence suggests that several aspects of necrosis are programmed tightly regulated, so targeting the process has become new trend for protection. Multiple cellular signaling pathways have been implicated necrotic cell death, death receptor-mediated extrinsic mitochondrial intrinsic pathways. However, precise mechanisms...
Abstract Background Circular RNAs are enriched in cardiac tissue and play important roles the pathogenesis of heart diseases. In this study, we aimed to investigate regulatory mechanism a conserved heart-enriched circRNA, circPan3, hypertrophy. Methods Cardiac hypertrophy was induced by isoproterenol. The progression cardiomyocyte assessed sarcomere organization staining, cell surface area measurement, expression levels markers. RNA interactions were detected pull-down assays, methylated...
The transient outward potassium current (Ito) plays important roles in action potential (AP) morphology and dynamics; however, its role the genesis of early afterdepolarizations (EADs) is not well understood. We aimed to study effects mechanisms Ito on EAD cardiac cells using combined experimental computational approaches. first carried out patch-clamp experiments isolated rabbit ventricular myocytes exposed H2O2 (0.2 or 1 mM), which EADs were induced at a slow pacing rate. eliminated by...
Cardiovascular disease is the major cause of death in patients with diabetes. Current treatment strategies for diabetes rely on lifestyle changes and glucose control to prevent angiopathy organ failure. Exenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, used as an add-on therapy insulin treatment. Exenatide also has multiple beneficial effects addition its hypoglycemic effects, such preventing hepatic steatosis protecting against cardiac injury from doxorubicin-induced...
Depression is a common comorbidity in patients with Parkinson's disease (PD) and can significantly impact their overall well-being. The combination of venlafaxine pramipexole standard treatment approach for depression PD. However, the effects incorporating psychological care into regimen remain unclear. This study aimed to investigate intervention disease, using pramipexole. clinical data 151 both depression, treated Geriatric Hospital Hainan from May 2021 2023, were analyzed...
Abstract Abnormal mitochondrial fission and mitophagy participate in the pathogenesis of many cardiovascular diseases. Baicalein is a key active component roots traditional Chinese medicinal herb Scutellaria baicalensis Georgi. It has been reported that baicalein can resist cardiotoxicity induced by several stress, but mechanisms operate protection cardiomyocytes need to be researched further. Here we report promote cell survival under oxidative stress up‐regulating expression level MARCH5...
Many studies have reported that microRNAs (miRs) are involved in the regulation of doxorubicin (DOX)-induced cardiotoxicity. MiR-194-5p has been significantly upregulated patients with myocardial infarction; however, its role diseases is still unclear. Various stimuluses can trigger endoplasmic reticulum (ER) stress and it may activate apoptosis signals eventually. This study aims to explore regulatory miR-194-5p DOX-induced ER cardiomyocyte apoptosis.H9c2 was treated 2 μM DOX induce...
Objectives To investigate the effects of integrative neuromuscular training (INT) on physical performance in elite female table tennis players. Methods Twenty-four Chinese players were randomized into either INT (n = 12) group or control (CON; n 12). performed four sessions every week for 8 weeks, while CON traditional fitness training. One repetition maximal (1RM), vertical jump, Y balance test and 30-meter sprinting tested before after intervention. Results No between groups differences...
Abstract Purpose Diabetic cardiomyopathy is the leading cause of death in diabetic patients, and mechanism by which factors other than hyperglycemia contribute to development unknown. Serum small extracellular vesicles (sEVs) carry bioactive proteins or nuclei, enter into remote tissues modulate cell functions. However, conditions, changes lipids carried sEVs has not been identified. Our study aims explore patients with cardiovascular disease, we hope provide new ideas for understanding role...
To investigate the changes of artemin protein expression in diabetic peripheral neuropathy (DPN) and to explore regulatory effect human adipose-derived stem cell (ADSC) exosomes on change expression.
3,4,5-Trimethoxycinnamic acid (TMCA), methyl 3,4,5-trimethoxycinnamate (M-TMCA) and p-methoxycinnamic (PMCA) have been identified as the major bioactive components in serum collected from rats treated with oral administration of Polygalae Radix ("YuanZhi," roots Polygala tenuifolia WILLD.), a traditional Chinese medicine used to relieve insomnia, anxiety heart palpitation. The present study was designed investigate its direct electrophysiological effects on isolated ventricular myocytes...
High fat (HF)-diet-induced insulin resistance is a major contributor to the pathogenesis of cardiovascular diseases. However, molecular mechanisms that regulate cardiac signaling are not fully understood. The regulatory role tafazzin in hearts HF-diet-fed mice investigated.Mice fed HF diet or low (LF) for up 24 weeks. After weeks, it found HF-diet-induced dysfunction linked overexpression mitochondrial protein tafazzin. Increased promotes fission and impairs signaling, which mediated by...
Line-changing strategies are key tactics that can contribute to the successful performance of table tennis players. The purposes this study were explore characters and development trend line-changing in top-level players compare differences between Chinese from other countries. A computerised notational analysis was performed by using specialised technical tactical video system “Ping Pong Military Division” with 80 matches played 24 right-hand male top-ranked as samples chose usage rate,...
Background: Interpretation of ultrasound findings thyroid nodules is subjective and labor-intensive for radiologists.Artificial intelligence (AI) a relatively objective efficient technology.We aimed to establish fully automatic detection diagnosis system based on AI technology by analyzing video sequences.Patients Methods: We prospectively acquired dynamic videos 1067 (804 training 263 validation) from December 2018 January 2021.All the patients underwent hemithyroidectomy or total...
Abstract The response of cardiac fibroblast proliferation to detrimental stimuli is one the main pathological factors causing heart remodeling. Reactive oxygen species (ROS) mediate fibroblasts. However, exact molecular mechanism remains unclear. In vivo, we examined oxidative modification miRNAs with miRNA immunoprecipitation O 8 G in animal models fibrosis induced by Ang II injection or ischemia‒reperfusion injury. Furthermore, vitro, constructed oxidation-modified miR-30c and investigated...
Abstract Background Circular RNAs (circRNAs) are differentially expressed in various cardiovascular diseases, including myocardial infarction (MI) injury. However, their functional role necroptosis-induced loss of cardiomyocytes remains unclear. We identified a cardiac necroptosis-associated circRNA transcribed from the Cacna1c gene (circCacna1c) to investigate involvement circRNAs cardiomyocyte necroptosis. Methods To circCacna1c during oxidative stress, H9c2 cells and neonatal rat were...