A5072691782- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Occupational and environmental lung diseases
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Metastasis and carcinoma case studies
- Radiomics and Machine Learning in Medical Imaging
- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gastric Cancer Management and Outcomes
- Medical Imaging and Pathology Studies
- Esophageal Cancer Research and Treatment
- Phagocytosis and Immune Regulation
- Immune cells in cancer
- Sarcoma Diagnosis and Treatment
- Myasthenia Gravis and Thymoma
- Immunotherapy and Immune Responses
- Adrenal and Paraganglionic Tumors
- Immune Cell Function and Interaction
- Glutathione Transferases and Polymorphisms
Kyushu University
2014-2025
Kyushu University Hospital
2022-2025
University Health Network
2018-2023
Toronto General Hospital
2020-2023
University of Toronto
2019-2023
Princess Margaret Cancer Centre
2018-2021
Tokai University
2017
Matsuyama Red Cross Hospital
2015
Nippon Steel Yawata Memorial Hospital
2012
ObjectivesThe programmed death ligand 1(PD-L1)/programmed cell protein 1 (PD-1) pathway is one of the most important checkpoint pathways for mediating tumor-induced immune suppression through T-cell exhaustion. Recently, targeted therapies using monoclonal antibodies against components this have been shown to reduce tumor burden in patients with non–small lung cancer (NSCLC). However, prognostic significance PD-L1 expression controversial and precise mechanisms gene activation yet be...
Defining the ontogeny of tumor-associated macrophages (TAM) is important to develop therapeutic targets for mesothelioma. We identified two distinct macrophage populations in mouse peritoneal and pleural cavities, monocyte-derived, small peritoneal/pleural (SPM), tissue-resident large (LPM). SPM rapidly increased tumor microenvironment after challenge contributed vast majority M2-like TAM. The selective depletion TAM by conditional deletion Dicer1 gene myeloid cells (D −/− ) promoted...
Abstract Background Preoperative nivolumab combination chemotherapy has shown its efficacy in resectable stage II–III non-small cell lung cancer and become one of the standard treatments. While preoperative is generally a regimen three cycles, when treatment prematurely discontinued remains unclear. Case presentation An 81-year-old man was diagnosed as adenocarcinoma (cT3N1M0, cStage IIIA). A computed tomography (CT) showed 58 mm mass left upper lobe with an intrapulmonary metastasis,...
ABSTRACT Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) provide therapeutic benefit in EGFR mutation–positive non–small cell lung cancer, but some individuals develop early resistance. We performed spatial transcriptomics analysis of pre- and posttreatment tumor samples from the same patients to explore underlying mechanisms such The proportion activation fibroblasts increased association with development resistance, whereas a distinct cluster showed necrosis...
Lung adenocarcinomas among never-smokers are more common in females than males. This implies that gender-dependent hormones promote smoking unrelated lung adenocarcinoma. We therefore investigated mRNA expression of aromatase, an intrinsic estrogen synthetase, adenocarcinoma and assessed its correlation to clinicopathologic factors, including EGFR mutations postsurgical prognosis.Aromatase primary tumor samples from 110 patients with was evaluated qRT-PCR. Inhibitory effects the aromatase...
Malignant pleural mesothelioma (MPM) is an intractable disease with extremely poor prognosis. Our clinical protocol for MPM of subablative radiotherapy (RT) followed by radical surgery achieved better survival compared to other multimodal treatments, but local relapse and metastasis remain a problem. This RT elicits antitumoral immune response that limited the immunosuppressive microenvironment generated regulatory T (Treg) cells. The antitumor effect immunotherapy simultaneously modulate...
Cancer cell repopulation during chemotherapy or radiotherapy is a major factor limiting the efficacy of treatment. stem cells (CSC) may play critical roles this process. We aim to demonstrate role mesothelioma (MSC) in treatment failure and eventually design specific target therapies against MSC improve malignant mesothelioma. Murine AB12 RN5 were used compare tumorigenicity mice. The expression CSC-associated genes was evaluated by quantitative real-time PCR both lines treated with...