A5102000436- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Chemotherapy-induced organ toxicity mitigation
- Carbohydrate Chemistry and Synthesis
- Oxidative Organic Chemistry Reactions
- Cardiac Ischemia and Reperfusion
- Asymmetric Synthesis and Catalysis
- Nausea and vomiting management
- Crustacean biology and ecology
- Synthetic Organic Chemistry Methods
- Energy and Environment Impacts
- Cerebrovascular and Carotid Artery Diseases
- Analytical Chemistry and Chromatography
- Pain Management and Opioid Use
- Cancer Treatment and Pharmacology
- Diabetes Treatment and Management
- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Climate Change Policy and Economics
- Social Acceptance of Renewable Energy
- Pharmacological Effects and Toxicity Studies
- Synthesis of Organic Compounds
- Magnesium in Health and Disease
- Cardiac Valve Diseases and Treatments
- Antibiotic Use and Resistance
Shizuoka General Hospital
2024-2025
Kyoto University
2015-2025
National Archives and Records Administration
2025
Nara Prefecture General Medical Center
2025
Kyushu University
2025
Komaki City Hospital
2023-2024
Toyama University Hospital
2023
Kyoto Municipal Institute of Industrial Technology and Culture
2007-2020
Kansai Medical University
2003-2019
University Medical Center
2019
✓ The gene expression of five matrix metalloproteinases (MMPs) and two tissue inhibitors (TIMPs) was studied in human gliomas vivo vitro to evaluate their roles glioma invasion. Simultaneous one four MMP genes TIMP found 17 surgical specimens, (gelatinase A) were simultaneously expressed three brains. concomitant overexpression gelatinase A, B, occasional matrilysin associated with the malignancy accompanied by TIMP-1 gene. In cell lines, TIMP-1, TIMP-2 constitutively all lines: lines;...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of Some Methyldisilanes Containing Functional GroupsMAKOTO KUMADA, MASAAKI YAMAGUCHI, YOSHIHIRO YAMAMOTO, JUN-ICHI NAKAJIMA, and KYO SHIINACite this: J. Org. Chem. 1956, 21, 11, 1264–1268Publication Date (Print):November 1, 1956Publication History Published online1 May 2002Published inissue 1 November 1956https://doi.org/10.1021/jo01117a013RIGHTS & PERMISSIONSArticle Views372Altmetric-Citations133LEARN ABOUT THESE METRICSArticle Views are...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereocontrol in the Polymerization of Methyl Methacrylate Mediated by Chiral Organolanthanide MetallocenesMichael A. Giardello, Yoshihiro Yamamoto, Laurent Brard, and Tobin J. MarksCite this: Am. Chem. Soc. 1995, 117, 11, 3276–3277Publication Date (Print):March 1, 1995Publication History Published online1 May 2002Published inissue 1 March 1995https://pubs.acs.org/doi/10.1021/ja00116a034https://doi.org/10.1021/ja00116a034research-articleACS...
The significance of the minimal secretory capacity pancreatic beta-cells for stability plasma glucose level was studied in 20 patients with insulin-dependent diabetes mellitus. Changes concentrations major counterregulatory hormones response to hypoglycemia were also investigated these clarify their contribution diabetic brittleness. beta-Cell function evaluated on basis elevation C-peptide immunoreactivity (CPR) during intravenous glucagon test a highly sensitive assay CPR that could detect...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and Intramolecular Rearrangements of Chloromethylpenta-methyldisilane 1-Chloromethyl-2-chlorotetramethyldisilaneMAKOTO KUMADA, JUN-ICHI NAKAJIMA, MITUO ISHIKAWA, YOSHIHIRO YAMAMOTOCite this: J. Org. Chem. 1958, 23, 2, 292–295Publication Date (Print):February 1, 1958Publication History Published online1 May 2002Published inissue 1 February...
Recent technical advances in interventional neuroradiology have made it possible to dilate cerebral arteries showing vasospasm after a subarachnoid hemorrhage. Although the reported effects of dilatation clinical cases been dramatic, few experimental studies mechanism action performed. It also is still unclear why dilated rarely show restenosis. Using scanning electron microscope, we examined changes three-dimensional structure connective tissues vessel walls balloon angioplasty. Femoral...
There are attempts to assess tumor heterogeneity by texture analysis. However, the ordered subsets-expectation maximization (OSEM) reconstruction method has problems depicting heterogeneities. The aim of this study was identify image parameters that improve ability depict internal necrosis using a self-made phantom simulates necrosis. Self-made phantoms were prepared polypropylene cylinders with inner diameters 18.0 mm and 6.0 mm. concentration ratios simulated : interior 4 0 1. For each...
Abstract Background Preoperative nivolumab combination chemotherapy has shown its efficacy in resectable stage II–III non-small cell lung cancer and become one of the standard treatments. While preoperative is generally a regimen three cycles, when treatment prematurely discontinued remains unclear. Case presentation An 81-year-old man was diagnosed as adenocarcinoma (cT3N1M0, cStage IIIA). A computed tomography (CT) showed 58 mm mass left upper lobe with an intrapulmonary metastasis,...
Abstract Background Field cancerization defined by multiple development of squamous cell carcinomas (SCCs) in upper aerodigestive tract was explained excessive alcohol intake. A dysfunctional mitochondrial aldehyde dehydrogenase 2 (Aldh2) delays the clearance acetaldehyde, a genotoxic metabolite, and increases SCC risks. TP53 plays key roles carcinogenesis. However, mechanism alcohol-mediated field has not been clearly elucidated. Methods We developed novel genetically engineered mouse...
Kabuki syndrome is a rare genetic disorder that causes multiple congenital anomalies, including characteristic facial features reminiscent of syndrome. It often associated with anomalies the kidneys and urinary tract as well immune abnormalities. While various autoimmune diseases have been reported in patients this syndrome, only one case membranoproliferative glomerulonephritis has documented. We herein report which immunoglobulin A nephropathy developed renal allograft, subsequently...
To develop an anti-obesity agent, we examined the combination effect of glucosyl hesperidin (G-hesperidin) and caffeine on obesity in mice. High-fat diet-induced obese KK mice were fed a low-fat diet with or without G-hesperidin, caffeine, their for 2 weeks. Decreases body weight significantly lower adipose tissue observed combination-fed but not G-hesperidin-fed caffeine-fed DNA microarray analysis mouse liver suggested that feeding G-hesperidin + was associated lipogenesis. Therefore,...
Sake is a traditional Japanese alcoholic beverage prepared by multiple parallel fermentation of rice. The process “yamahai-ginjo-shikomi” sake mainly performed three microbes, Aspergillus oryzae, Saccharomyces cerevisiae, and Lactobacilli; the levels various metabolites fluctuate during sake. For evaluation process, we monitored concentration moderate-sized molecules (m/z: 200–1000) dynamically changed This analysis revealed that six compounds were main factors with characteristic...
Abstract Alcohol consumption is the key risk factor for development of esophageal squamous cell carcinoma (ESCC), and acetaldehyde, a metabolite alcohol, an alcohol-derived major carcinogen that causes DNA damage. Aldehyde dehydrogenase2 (ALDH2) enzyme detoxifies its activity reduced by ALDH2 gene polymorphism. Reduction in increases blood, salivary breath acetaldehyde levels after alcohol intake, it deeply associated with ESCC. Heavy individuals polymorphism significantly elevates ESCC;...
Abstract Objectives This study assessed the cost-effectiveness of combination treatment with gemcitabine and cisplatin compared to alone for advanced biliary tract cancer (BTC) in Japan. Methods A monthly transmitted Markov model three states was constructed based on Japan BT-22 trial. Transition probabilities among health were derived from a trial conducted converted appropriate parameters our model. The associated cost components, obtained receipt-based survey undertaken at Aichi Medical...