A5008779567- Cancer-related Molecular Pathways
- Esophageal Cancer Research and Treatment
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Treatments and Studies
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- HER2/EGFR in Cancer Research
- DNA Repair Mechanisms
- Analog and Mixed-Signal Circuit Design
- Head and Neck Cancer Studies
- Esophageal and GI Pathology
- Oral and Maxillofacial Pathology
- Monoclonal and Polyclonal Antibodies Research
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Cancer Diagnosis and Treatment
- Healthcare Systems and Practices
- Alcohol Consumption and Health Effects
- Synthesis and Biological Activity
- Curcumin's Biomedical Applications
- Cytokine Signaling Pathways and Interactions
Kyoto University
2019-2025
Columbia University Irving Medical Center
2024-2025
Herbert Irving Comprehensive Cancer Center
2024
Columbia University
2024
Kyoto University Hospital
2022
Kurashiki Central Hospital
2016
Panasonic (Japan)
2009-2010
Kobe Pharmaceutical University
2005
Conventional continuous-time (CT) delta-sigma (¿¿) analog-to-digital converters (ADCs) consume large amount of power in operational amplifiers a loop-filter. We propose new loop-filter with single-opamp resonator, ringing-relaxation filter and passive resistor adder to lower consumption. These three techniques are essential for designing high-order delta sigma modulators low oversampling ratio. Because the resonator reduces number opamps, displaces conventional active alleviates burden on...
211 Background: Colorectal cancer remains the third most fatal form of for males and females combined, with K-Ras mutations present in approximately 40% all cases. These drive progression confer resistance to conventional therapies, underscoring need novel treatment strategies. Ferroptosis, a regulated non-apoptotic cell death characterized as iron-dependent lipid peroxidation, has emerged target therapy. A study published 2023 found that mutant pancreatic ductal adenocarcinoma non-small...
Abstract Background Field cancerization defined by multiple development of squamous cell carcinomas (SCCs) in upper aerodigestive tract was explained excessive alcohol intake. A dysfunctional mitochondrial aldehyde dehydrogenase 2 (Aldh2) delays the clearance acetaldehyde, a genotoxic metabolite, and increases SCC risks. TP53 plays key roles carcinogenesis. However, mechanism alcohol-mediated field has not been clearly elucidated. Methods We developed novel genetically engineered mouse...
Esophageal squamous cell carcinoma (ESCC) is one of the most intractable cancers, so development novel therapeutics has been required to improve patient outcomes. Curcumin, a polyphenol from Curcuma longa, exhibits various health benefits including antitumor effects, but its clinical utility limited because low bioavailability. Theracurmin® (THC) highly bioavailable curcumin dispersed with colloidal submicron particles. We examined effects THC on ESCC cells by viability assay, colony and...
Abstract Alcohol consumption is the key risk factor for development of esophageal squamous cell carcinoma (ESCC), and acetaldehyde, a metabolite alcohol, an alcohol-derived major carcinogen that causes DNA damage. Aldehyde dehydrogenase2 (ALDH2) enzyme detoxifies its activity reduced by ALDH2 gene polymorphism. Reduction in increases blood, salivary breath acetaldehyde levels after alcohol intake, it deeply associated with ESCC. Heavy individuals polymorphism significantly elevates ESCC;...
Esophageal squamous cell carcinoma (ESCC) is a disease characterized by high mutation rate of the TP53 gene, which plays pivotal roles in DNA damage response (DDR) and regulated checkpoint kinase (CHK) 2. CHK1 another key DDR-related protein, its selective inhibition suggested to be particularly sensitive TP53-mutated cancers, because loss both pathways (CHK1 and/or CHK2-p53) lethal due serious impairment DDR. Such therapeutic strategy termed synthetic lethality. Here, we propose novel based...
Abstract Background and study aims Radial incision cutting (RIC) was established to improve refractory esophageal anastomotic strictures but its efficacy safety for nonsurgical remain unclear. To evaluate the usefulness of RIC in strictures, we retrospectively compared outcomes between surgical strictures. Patients methods We studied 54 consecutive patients who were initially treated with benign stricture. The variables included dysphasia score improvement rate, frequency repeated RIC,...
Cancer of unknown primary (CUP) is usually treated with nonselective and empirical chemotherapy; however, its prognosis generally poor, a median survival less than year. Thus, clinicians eagerly await the development more effective treatment strategies. In recent years, advances in next-generation sequencing (NGS) have made it possible to analyze comprehensively genome individual cancers. NGS has identified many genomic alterations, some which are potential molecular targets specific agents....
Clinical cancer genome sequencing detects oncogenic variants that are potential targets for treatment, but it also of unknown significance. These may interact with each other to influence tumor pathophysiology, however, such interactions have not been fully elucidated. Additionally, the effect target therapy those unclarified. In this study, we investigated biological functions a HER2 mutation (G776S mutation) pathological significance, which was detected together APC by samples from...
In system LSIs, costs of analog circuits are getting increased relatively for rapid cost reduction digital circuits. To satisfy given specifications in the design, including low power and small area, designers have to select an optimal solution among large combination following alternatives: which architecture should be adopted; what type transistors taken; whether digitally assisting technologies used or not, etc. A design based on experience intuition cannot lead optimum a short time....
Barrett’s esophagus (BE) is a common precancerous lesion that can progress to esophageal adenocarcinoma (EAC). There are significant alterations in the microbiome progression from healthy BE EAC, including an increased abundance of variety lactate-producing bacteria and increase lactate tumor microenvironment, as predicted by metabolic modeling. The role bacterial EAC unknown. Here, we utilize patient-derived organoid (PDO) models demonstrate inhibits growth proliferation PDOs through...
Abstract The human esophagus, derived from the anterior foregut endoderm, requires proper dorsal-ventral patterning for development. transcription factor SOX2, crucial in this process, when dysregulated, leads to congenital esophageal abnormalities. EPHA2, a receptor tyrosine kinase, is vital various developmental processes and cancer models, where it activates SOX2. This study demonstrates that EPHA2 regulates SOX2 expression during development using iPSCs iPSC-derived organoids (HEO)....
Despite advanced therapeutics, esophageal squamous cell carcinoma (ESCC) remains one of the deadliest cancers. Here, we propose a novel therapeutic strategy based on synthetic lethality combining trifluridine/tipiracil and MK1775 (WEE1 inhibitor) as treatment for ESCC. This study demonstrates that trifluridine induces single-strand DNA damage in ESCC cells, evidenced by phosphorylated replication protein 32. The response includes cyclin-dependent kinase 1 (CDK1) (Tyr15) phosphorylation CDK1...
<p>Phosphorylated and total CHK1 or CHK2 protein levels in TE-11R cells treated with prexasertib.</p>
<p>TP53 and other DNA damage response-related gene mutations in human esophageal squamous cell carcinomas.</p>
<p>TP53 and other DNA damage response-related gene mutations in human esophageal squamous cell carcinomas.</p>
<p>The time-course of body-weight changes in mice treated with FTD/TPI and/or prexasertib.</p>
<p>The time-course of body-weight changes in mice treated with FTD/TPI and/or prexasertib.</p>