A5102819887- Cancer Research and Treatments
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Colorectal Cancer Treatments and Studies
- Electronic Health Records Systems
- Nerve injury and regeneration
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Pancreatic and Hepatic Oncology Research
- Organ Transplantation Techniques and Outcomes
- Neurological disorders and treatments
- Cancer Genomics and Diagnostics
- Transplantation: Methods and Outcomes
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Surgical Treatments
- HER2/EGFR in Cancer Research
- Cholinesterase and Neurodegenerative Diseases
- Heart Failure Treatment and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Pancreatitis Pathology and Treatment
- Neurological Disease Mechanisms and Treatments
- Neuroendocrine Tumor Research Advances
- Cerebrospinal fluid and hydrocephalus
Showa University
2016-2025
Minoh City Hospital
2025
Kyoto University
2010-2024
Kyoto University Hospital
2011-2024
Kitasato University
1997-2023
Kansai Medical University
2022
University of Shizuoka
2022
Otsuka (Japan)
2022
Tokyo Medical and Dental University
2020
Weatherford College
2020
Purpose Programmed death-1 (PD-1), a coinhibitory immune signal receptor expressed in T cells, binds to PD-1 ligand and regulates antitumor immunity. Nivolumab is an anti–PD-1 antibody that blocks signaling. We assessed the safety activity of nivolumab patients with platinum-resistant ovarian cancer. Patients Methods Twenty cancer were treated intravenous infusion every 2 weeks at dose 1 or 3 mg/kg (constituting two 10-patient cohorts) from October 21, 2011. This phase II trial defined...
Natural products produced by microorganisms are important starting compounds for drug discovery. Secondary metabolites, including antibiotics, have been isolated from different Streptomyces species. The production of these metabolites depends on the culture conditions. Therefore, development a new method can facilitate discovery natural products. Here, we show that mycolic acid-containing bacteria influence biosynthesis cryptic in red pigment lividans TK23 was induced coculture with...
Abstract Several previous studies reported that the neutrophil‐to‐lymphocyte ratio ( NLR ) could be a promising prognostic factor for patients with cancer. We aimed to determine value of in advanced pancreatic cancer APC following palliative chemotherapy. retrospectively reviewed 252 consecutive receiving chemotherapy between January 2006 and December 2012. classified according pretreatment values (≤5 or >5) into two groups investigated difference treatment outcomes, including time...
Abstract The aim of this study was to evaluate the association between postural orthostatic tachycardia syndrome ( POTS ) and circulating antiganglionic acetylcholine receptor gAChR antibodies. We reviewed clinical assessments Japanese patients with , determined presence antibodies in serum samples from those patients. Luciferase immunoprecipitation systems detected anti‐ α 3 β 4 sera (29%). Antecedent infections were frequently reported Moreover, autoimmune markers comorbid diseases also...
There is an urgent need to establish blood biomarkers for Alzheimer's disease (AD). Although it has been speculated that brain-derived neurotrophic factor (BDNF) associated with AD, whether can be used as a biomarker yet determined. We serum, cerebrospinal fluid (CSF), and medial temporal lobe atrophy from patients AD evaluate the association of BDNF assess its severity. For analysis, 66 participants [21 normal controls (NCs) cognitive function, 22 mild impairment (MCI) due 23 AD] were...
Objective The Clarity AD phase III trial showed that lecanemab reduced amyloid markers in early Alzheimer's disease (AD) and resulted less decline on measures of cognition function than placebo. Herein, we aimed to characterize amyloid‐β (Aβ) protofibril (PF) captured by human cerebrospinal fluid (CSF) from living participants with different stages AD, which enable an enhanced understanding the dynamic changes lecanemab‐associated Aβ‐PF (Lec‐PF) vivo. Methods We newly developed a unique...
To understand the genetics of steroid-sensitive nephrotic syndrome (SSNS), we conducted a genome-wide association study in 987 childhood SSNS patients and 3,206 healthy controls with Japanese ancestry. Beyond known associations HLA-DR/DQ region, common variants NPHS1-KIRREL2 (rs56117924, P=4.94E-20, odds ratio (OR) =1.90) TNFSF15 (rs6478109, P=2.54E-8, OR=0.72) regions achieved significance were replicated Korean, South Asian African populations. Trans-ethnic meta-analyses including...
<i>Objective:</i> We investigated the expression and function of hedgehog (Hh) pathway in human esophageal squamous cell carcinoma (ESCC). <i>Methods:</i> The Hh molecules were detected 34 ESCC lines by RT-PCR. Subsequently, we effects cyclopamine, a specific inhibitor pathway, on proliferation, migration invasion. Next, siRNA targeting Gli-1 examined. Immunohistochemically, was studied 104 specimens compared with clinicopathological characteristics patients....
5511 Background: Programmed death-1 (PD-1) is a co-inhibitory receptor expressed on activated T cells which regulates antitumor immunity. Nivolumab fully-humanized IgG4 that blocks the engagement of PD-1 by ligands. Here we report first trial for clinical application nivolumab in ovarian cancer patients. Methods: was administered every 2 weeks to patients with advanced or relapsed, platinum–resistant cancer, at doses 1 3 mg/kg during two cohort examination (10 each). The phase II efficacy...
Alzheimer's disease (AD) is a slowly progressive form of dementia, characterized by memory impairment and cognitive dysfunction. AD mainly the deposition amyloid β (Aβ) plaques intracellular neurofibrillary tangles in brain, along with neuronal degeneration high levels oxidative stress. Cilostazol (CSZ) was recently found to suppress progression decline patients stable receiving acetylcholinesterase inhibitors. This present study aimed clarify mechanism which CSZ protects neurons from...
<i>Objective:</i> Osteopontin (OPN) is a secreted integrin-binding glycophosphoprotein that may have role in head and neck squamous cell carcinoma (SCC). To evaluate the clinical significance of OPN esophageal (ESCC), we compared plasma levels with those common tumor markers. <i>Methods:</i> Preoperative were measured by enzyme immunoassay 103 ESCC patients. Serum SCC antigen, Cyfra 21-1, carcinoembryonic antigen (CEA) also routinely at admission radioimmunoassay....
Abstract In this study, we investigated the clinicopathologic significance of low-affinity p75 neurotrophin receptor (p75NTR; which is expressed in stem/progenitor cell fraction normal esophageal epithelial cells) 187 resected squamous carcinoma (ESCC) specimens and found that ∼50% ESCC p75NTR. Our investigation using lines showed p75NTR was intensely cells with high colony-forming capacity but they were sensitive to death on inhibition expression transient transfection small interfering RNA...
Staphyloxanthin, a yellow pigment produced by methicillin-resistant Staphylococcus aureus (MRSA), is virulent factor escaping from the host immune system. A new screening method for inhibitors of staphyloxanthin production MRSA was established using paper disks. By this method, were selected natural product library (ca. 300) and actinomycete culture broths 1000). From library, four known lipid metabolism, cerulenin, dihydrobisvertinol, xanthohumol zaragozic acid, found to inhibit production;...
We have employed upper arm central venous ports (UACVPs) since 2006 for long-term intravenous chemotherapy (CTx) or fluid supplementation. evaluated the availability of CVPs implanted in to determine whether UACVPs could be one treatment options besides chest terms CVP-related complications.We reviewed medical records all patients who underwent subcutaneous implantation at Kyoto University Hospital from 1 April, 30 June, 2009. assessed indwelling duration and incidences early late...
1. Electrical responses of the taste receptors lips in sea catfish (Plotosus anguillaris (LACÉPÈDE)) to various stimuli were studied by recording from single facial nerve fibers.2. In addition tactile fibers, innervating barbels contains fibers which respond specifically passive bending barbels. The extremely high sensitivities and mechanical bilaterally symmetrical innervation branches suggest that above-mentioned pressure may subserve rheotropic orientation this fish.3. Study fiber showed...