A5034151452- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Occupational and environmental lung diseases
- Epilepsy research and treatment
- Pleural and Pulmonary Diseases
- Medical Imaging and Pathology Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pharmacological Effects and Toxicity Studies
- Cancer Research and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Nutrition and Health in Aging
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Myasthenia Gravis and Thymoma
- Metabolism and Genetic Disorders
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Metastasis and carcinoma case studies
- Neuroendocrine Tumor Research Advances
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
Kyushu University
2014-2023
Kyushu University Hospital
2019-2022
National Kyushu Medical Center
2022
National Hospital Organization Kyushu Cancer Center
2007-2021
Oita Red Cross Hospital
2016-2018
Chiba University
2013-2016
University Health Network
2011-2016
American College of Chest Physicians
2015
University of Toronto
1998-2014
Toronto Public Health
2013
ObjectivesThe programmed death ligand 1(PD-L1)/programmed cell protein 1 (PD-1) pathway is one of the most important checkpoint pathways for mediating tumor-induced immune suppression through T-cell exhaustion. Recently, targeted therapies using monoclonal antibodies against components this have been shown to reduce tumor burden in patients with non–small lung cancer (NSCLC). However, prognostic significance PD-L1 expression controversial and precise mechanisms gene activation yet be...
Summary Purpose: De novo STXBP1 mutations have been found in individuals with early infantile epileptic encephalopathy suppression‐burst pattern (EIEE). Our aim was to delineate the clinical spectrum of subjects mutations, and examine their biologic aspects. Methods: analyzed 29 54 cases cryptogenic EIEE West syndrome, respectively, as a second cohort. RNA splicing lymphoblastoid cells from subject harboring c.663 + 5G>A mutation. Expression protein missense examined neuroblastoma2A...
The gastrointestinal microbiota was reported as an important factor for the response to cancer immunotherapy. Probiotics associated with dysbiosis and bacterial richness may affect efficacy of immunotherapy drugs. However, clinical impact probiotics on in patients nonsmall cell lung (NSCLC) is poorly understood. outcomes 294 advanced or recurrent NSCLC who received antiprogrammed death-1 (PD-1) therapy (nivolumab pembrolizumab monotherapy) at three medical centers Japan were analyzed our...
<h3>Background</h3> Disruption of granulocyte/macrophage colony-stimulating factor (GM-CSF) signalling causes pulmonary alveolar proteinosis (PAP). Rarely, genetic defects in neonatal or infant-onset PAP have been identified <i>CSF2RA</i>. However, no report has clearly any function-associated defect <i>CSF2RB</i>. <h3>Methods and results</h3> The patient was diagnosed with at the age 36 developed respiratory failure. She negative for GM-CSF autoantibody had underlying disease. Signalling...
We evaluated the influence of gender on penetrance GTP-cyclohydrolase I (GCH) gene mutations in hereditary progressive dystonia/dopa-responsive dystonia (HPD/DRD) and determined whether some apparently sporadic HPD/DRD patients owe their disorder to a de novo mutation GCH gene. Previous clinical investigations have shown predominance affected women, with approximately half being sporadic. conducted genomic DNA sequencing five families having at least two generations members four cases all...
Abstract Cancer immunotherapy has shown promising results when combined with chemotherapy. Blocking CTLA-4 signaling by monoclonal antibody between cycles of chemotherapy may inhibit cancer cell repopulation and enhance the antitumoral immune reaction, thus improve efficacy in mesothelioma. The impact blockade on early stage tumor development was evaluated a subcutaneous murine mesothelioma model. blocking administered following each cycle chemotherapy, monotherapy included as controls....
<b><i>Background:</i></b> Elastography is a relatively new technology that can generate images reflective of tissue stiffness (elasticity). Neoplastic usually stiffer than normal structures. <b><i>Objectives:</i></b> The aim this study was to evaluate the feasibility and utility elastography when combined with convex-probe endobronchial ultrasound (CP-EBUS) for predicting localizing metastatic lymph nodes during transbronchial needle aspiration...
Abstract Purpose: Malignant pleural mesothelioma (MPM) is a rare but aggressive disease with few therapeutic options. The tumor–stromal interface important in MPM, this lost cell lines, the main model used for preclinical studies. We sought to characterize MPM patient-derived xenografts (PDX) determine their suitability as models and whether tumors that engraft reflect more biological phenotype. Experimental Design: Fresh were harvested from extrapleural pneumonectomy, decortication, or...
Abstract To examine the association between 18 F-fluorodeoxyglucose ( F-FDG) uptake in positron emission tomography/computed tomography (PET/CT) and response to anti-programmed cell death-1 (PD-1) monoclonal antibody therapy non-small lung cancer (NSCLC) patients, 89 patients with advanced or recurrent NSCLC were retrospectively analysed. Maximum standardized value (SUVmax) F-FDG PET/CT anti-PD-1 antibodies recorded. A cut-off of SUVmax was determined by receiver operating characteristic...
There are great expectations for artificial intelligence (AI) in medicine. We aimed to develop an AI prognostic model surgically resected non-small cell lung cancer (NSCLC). This study enrolled 1049 patients with pathological stage I-IIIA NSCLC at Kyushu University. set 17 clinicopathological factors and 30 preoperative 22 postoperative blood test results as explanatory variables. Disease-free survival (DFS), overall (OS), cancer-specific (CSS) were objective The eXtreme Gradient Boosting...
Recently, mutations of the GTP-cyclohydrolase I (GTP-CH I) gene, which catalyzes first step in tetrahydrobiopterin (BH4) biosynthesis, were discovered Japanese patients with hereditary progressive dystonia/dopa-responsive dystonia (HPD/DRD). However, it has not been confirmed that non-Japanese also contain same or whether these are specific to HPD/DRD. In this study, two novel nonsense exon GTP-CH gene and a new mutation at splice acceptor site intron identified an autopsied case...
Abstract Xeroderma pigmentosum is an unusual neurocutaneous disorder. Recent studies have classified patients with xeroderma into 10 groups by somatic cell hybridization methods. In this report we describe 32 Group A pigmentosum, including 1 patient atypical case, who were assessed for neurological complications. Of these patients, 17 had microcephaly, 13 short stature, and 21 mental retardation. over 7 years of age, sensorineural deafness spinocerebellar signs such as nystagmus, dysarthria,...