A5027037789- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Transplantation: Methods and Outcomes
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Myasthenia Gravis and Thymoma
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Immunotherapy and Biomarkers
- Cardiac tumors and thrombi
- Renal Transplantation Outcomes and Treatments
- Vascular Anomalies and Treatments
- Polyomavirus and related diseases
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Treatments and Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Congenital Diaphragmatic Hernia Studies
- Trauma Management and Diagnosis
- Gastrointestinal disorders and treatments
- Organ and Tissue Transplantation Research
- Esophageal and GI Pathology
Chiba University
2016-2025
Chiba University Hospital
2015-2025
International University of Health and Welfare
2023
National Cancer Center Hospital East
2022
Soochow University
2022
First Affiliated Hospital of Soochow University
2022
Dalian Medical University
2022
Showa University
2022
Fistula Foundation
2020
Osaka Prefectural Medical Center
2019
Statistical data of mortality and morbidity related to anesthesia have not been reported in Japan since World War II. The need comprehensively examine the events cardiac arrest as well prompted first national study Japan.Confidential questionnaires were sent all Society Anesthesiologists Certified Training Hospitals every year from 1994 through 1998. Collected analyzed for incidence other critical during surgery, their outcomes within 7 postoperative days. principal causes incidents also...
Longitudinal relaxation times (T1) of 20 brain tumors were calculated in vivo using a whole-body magnetic resonance unit with 0.15-T resistive magnet. Images employing standard inversion recovery pulse sequences different intervals between the 180 degrees and selective excitation pulses compared on every point 256 X pixel matrix. Tumor, white matter, gray matter sampled from each patient computed T1 image for measurement. Astrocytomas, neurinomas, metastatic showed longer values than did...
<b>Objective</b> The purpose was to determine the rates of postoperative pulmonary complications, and clarify impact COPD on long-term survival in lung cancer patients after surgical resection. <b>Methods</b> A retrospective chart review performed 1,461 who had undergone resection for from 1990 2005. Classification severity based spirometric guidelines Global Initiative Chronic Obstructive Lung Disease (GOLD). Postoperative complication among four groups were compared overall...
<b><i>Background:</i></b> Elastography is a relatively new technology that can generate images reflective of tissue stiffness (elasticity). Neoplastic usually stiffer than normal structures. <b><i>Objectives:</i></b> The aim this study was to evaluate the feasibility and utility elastography when combined with convex-probe endobronchial ultrasound (CP-EBUS) for predicting localizing metastatic lymph nodes during transbronchial needle aspiration...
Abstract Obliterative bronchiolitis (OB) post-lung transplantation involves IL-17–regulated autoimmunity to type V collagen and alloimmunity, which could be enhanced by complement activation. However, the specific role of activation in lung allograft pathology, IL-17 production, OB is unknown. The current study examines OB. Complement-regulatory protein (CRP) (CD55, CD46, receptor 1–related y/CD46) expression was downregulated human murine OB; C3a, a marker activation, upregulated locally....
Background Invariant natural killer T (iNKT) cells produce copious amounts of cytokines in response to specific glycolipid antigens such as α-galactosylceramide (αGalCer) presented by CD1d-expressing antigen-presenting (APCs), thus orchestrating other immune fight tumors. Because their ability induce strong antitumor responses activated αGalCer, iNKT have been studied for application cancer immunotherapy. In our previous phase I/II trial non-small cell lung (NSCLC) patients who had completed...
Lung transplant survival is limited by obliterative bronchiolitis (OB), but the mechanisms of OB development are unknown. Previous studies in a mouse model orthotopic lung transplantation suggested requirement for IL-17. We have used this to investigate source IL-17A and T cells producing IL-17A. The major sources were CD4(+) γδ cells. Depletion led significantly decreased frequency number IL-17A(+) lymphocytes was sufficient prevent acute rejection OB. However, mice with STAT3-deficient...
Abstract OBJECTIVES Radiologically invasive non-small-cell lung cancer, defined as consolidation size to maximum tumour diameter ratio of over 0.5, is associated with pathological invasiveness and worse prognosis. However, there are no real-world, nationwide database studies on limited resections that consider radiological invasiveness. This study aimed investigate the prognostic validity resection, such segmentectomy wedge in cStage IA (TNM 8th edition) radiologically cancer. METHODS We...
Postoperative radiotherapy (PORT), especially using modern technology, for patients with stage IIIA-N2 non-small cell lung cancer (NSCLC) is controversial. We retrospectively investigated 112 NSCLC who underwent complete resection of the tumor in our institution from 1986 through 2003. Among 91 determined suitable candidates PORT postoperatively, 45 received (PORT group) and 46 did not (non-PORT group). analyzed correlation between use clinicopathological characteristics, number involved...
Chemokines play an important role in the pathogenesis of non-small cell lung cancer (NSCLC). However, aberrant methylation CXCL12 has not been examined NSCLC. mRNA expression and were 17 NSCLC lines by RT-PCR methylation-specific PCR (MSP). MSP was performed on 236 tumor specimens from patients who received curative intent surgery. CXCR4 protein 90 immunohistochemistry. Down-regulation found 10 (59%) compared with normal bronchial cells. Treatment 8 expression-negative a demethylating agent...
Lung adenocarcinoma is classified morphologically into five histological subtypes according to the WHO classification. While each subtype correlates with a distinct prognosis, molecular basis has not been fully elucidated. Here we conducted DNA methylation analysis of 30 lung cases annotated predominant and three normal using Infinium BeadChip. Unsupervised hierarchical clustering revealed subgroups different levels: high-, intermediate-, low-methylation epigenotypes (HME, IME, LME)....
Abstract Background During endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA), the sonographic findings of B‐mode imaging, as well elastography, can be obtained noninvasively and used for prediction nodal metastasis. Methods Patients with lung cancer or suspected who underwent EBUS‐TBNA were recorded prospectively reviewed retrospectively. Both elastographic independently evaluated each lymph node. The features classified according to previously published criteria....
Background Pulmonary mucoepidermoid carcinoma is a rare salivary gland-type neoplasm. We aimed to elucidate the optimal management of this condition by reviewing treatment outcomes patients at our institution with lung. Methods performed retrospective review all pulmonary who underwent surgical between January 1993 and December 2012. reviewed patients’ clinical characteristics therapeutic interventions undertaken. Results Nine were evaluated in study, 7 whom female. The median age was 54...
Carcinoma cells often modulate coagulation and fibrinolysis among cancer patients. Plasma dimerized plasmin fragment D (D-dimer) has been reported as a prognostic marker of various types malignancies, including non-small cell lung (NSCLC). However, the associations between plasma D-dimer level peripheral small NSCLC remain unclear.Three hundred sixty-two patients with who underwent radical surgery were retrospectively reviewed. Patients received anticoagulation therapy before or lacked...