A5049879280- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Pleural and Pulmonary Diseases
- Radiomics and Machine Learning in Medical Imaging
- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Research Studies
- Congenital Diaphragmatic Hernia Studies
- Myasthenia Gravis and Thymoma
- Medical Imaging Techniques and Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Cancer Diagnosis and Treatment
- Pulmonary Hypertension Research and Treatments
- Voice and Speech Disorders
- Cardiac tumors and thrombi
- Renal Transplantation Outcomes and Treatments
- Airway Management and Intubation Techniques
- Pneumothorax, Barotrauma, Emphysema
- Trauma Management and Diagnosis
Chiba University
2015-2025
Chiba Cancer Center
2009-2025
Chiba University Hospital
2025
Fistula Foundation
2020
Brigham and Women's Hospital
2016-2019
Harvard University
2016-2019
Kyoto University
2018
Jichi Medical University
2010
Abstract Purpose: Anaplastic lymphoma kinase (ALK) fusion genes represent novel oncogenes for non–small cell lung cancers (NSCLC). Several ALK inhibitors have been developed, and are now being evaluated in ALK-positive NSCLC. The feasibility of detecting samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) was determined. clinicopathologic characteristics cancer were also analyzed. Experimental Design: From April 2008 to July 2009, NSCLC cases with...
We conducted a phase III randomized controlled trial (RCT) to investigate the efficacy of postsurgical adjuvant immunotherapy combined with chemotherapy. The targets were residual micrometastases and clones resistant Between April 2007 July 2012, 103 non-small cell lung cancer patients randomly assigned receive either chemo-immunotherapy (group A) or chemotherapy B). consisted adoptive transfer autologous activated killer T cells dendritic obtained from patients’ own regional lymph nodes....
The efficacy of sublobar resection primary lung cancer have been proven in recent years. However, for highly invasive increases local recurrence. We developed and validated multiple machine learning models predicting pathological invasiveness based on preoperative [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) computed (CT) radiomic features.Overall, 873 patients who underwent lobectomy or segmentectomy were enrolled. Radiomics features extracted from PET/CT images with the...
Lung adenocarcinoma is classified morphologically into five histological subtypes according to the WHO classification. While each subtype correlates with a distinct prognosis, molecular basis has not been fully elucidated. Here we conducted DNA methylation analysis of 30 lung cases annotated predominant and three normal using Infinium BeadChip. Unsupervised hierarchical clustering revealed subgroups different levels: high-, intermediate-, low-methylation epigenotypes (HME, IME, LME)....
Background: The ability to predict survival in patients with lymph node metastasis has long been elusive. After surgery, the basis for decision-making on combination treatment of is not clear. purpose this study was thus build a nomogram model effectively overall (OS) non-small cell lung cancer (NSCLC) and metastasis. number dissected nodes (NDLN), positive (NPLN), ratio (LNR), log odds (LODDS) were included determine risk factors advanced NSCLC. Methods: data 5,132 NSCLC (N1 or N2)...
Abstract Background During endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA), the sonographic findings of B‐mode imaging, as well elastography, can be obtained noninvasively and used for prediction nodal metastasis. Methods Patients with lung cancer or suspected who underwent EBUS‐TBNA were recorded prospectively reviewed retrospectively. Both elastographic independently evaluated each lymph node. The features classified according to previously published criteria....
Carcinoma cells often modulate coagulation and fibrinolysis among cancer patients. Plasma dimerized plasmin fragment D (D-dimer) has been reported as a prognostic marker of various types malignancies, including non-small cell lung (NSCLC). However, the associations between plasma D-dimer level peripheral small NSCLC remain unclear.Three hundred sixty-two patients with who underwent radical surgery were retrospectively reviewed. Patients received anticoagulation therapy before or lacked...
Abstract Tumor spread through air spaces (STAS) in non-small-cell lung cancer (NSCLC) is known to influence a poor patient outcome, even patients presenting with early-stage disease. However, the pre-operative diagnosis of STAS remains challenging. With progress radiomics-based analyses several attempts have been made predict based on radiological findings. In present study, NSCLC which located peripherally and tumors ≤ 2 cm size computed tomography (CT) that were potential candidates for...
Tracheal stenosis and fistula are critical conditions with severe symptoms necessitating prompt intervention, making tracheal stent insertion a suitable treatment option. This study aimed to describe the efficacy of stenting using less invasive flexible bronchoscope for malignant tumors. Medical records at Chiba University Hospital from January 2008 December 2021 were retrospectively examined. During this period, 76 stents placed in 63 patients. Thirteen patients who underwent self-expanding...
Patients with idiopathic pulmonary fibrosis (IPF) have higher risk of developing lung cancer, for example, squamous cell carcinoma (SCC), and show poor prognosis, while the molecular basis has not been fully investigated. Here we conducted DNA methylome analysis SCC using 20 samples with/without IPF, noncancerous tissue from smokers/nonsmokers, Infinium HumanMethylation 450K array. was clustered into low- high-methylation epigenotypes by hierarchical clustering analysis. Genes...
Background: We aimed to identify the factors associated with postoperative pain, quality of life, and development chronic pain after lung cancer surgery, including sensation threshold, fentanyl sensitivity, surgical procedures. Methods: conducted a single-center prospective observational study involving patients. Brief inventory, nine items concerning was investigated at 1 week, month, 3 months postoperatively. Pain threshold sensitivity were assessed preoperatively. Results: Of 146 patients...
Radical treatment for non-small cell lung cancer (NSCLC) combined with idiopathic pulmonary fibrosis (IPF) is challenging to plan due the invasiveness of and an acute exacerbation (AE) IPF that sometimes lethal.We intend conduct PIII-PEOPLE study (NEJ034), which a phase III multicenter prospective randomized controlled clinical trial, validate effect perioperative pirfenidone therapy (PPT), involving oral (600 mg) administration 14 days after registration followed by (1,200 more than before...
Introduction: Immune checkpoint inhibitors have recently been approved for treatment of early-stage non-small cell lung cancer (NSCLC) in the perioperative setting based on phase 3 trials.However, characteristics such patients who are prone to recurrence after adjuvant chemotherapy or likely benefit from postoperative immunotherapy remained unclear.Methods: This biomarker study (WJOG12219LTR) was designed evaluate stem markers (CD44 and CD133), programmed death-ligand 1 (PD-L1) expression...
Nodal staging of lung cancer is important for selecting surgical candidates. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) was evaluated as a modality nodal patients with potentially node-positive non-small cell (NSCLC).Endobronchial used NSCLC radiological N2/3 disease (short axis >10 mm on computed tomography and/or standardized positron emission uptake value >2.5 2-deoxy-2[F-18] fluoro-D-glucose tomography), T-stage ≥ T2, or positive serum carcinoembryonic...