A5039663004- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Neuroblastoma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Cancer Research and Treatments
- Glycosylation and Glycoproteins Research
- Immune Response and Inflammation
- Peptidase Inhibition and Analysis
- Cancer Cells and Metastasis
- Intestinal and Peritoneal Adhesions
- Intraperitoneal and Appendiceal Malignancies
- Photoreceptor and optogenetics research
- Vitamin C and Antioxidants Research
- Antimicrobial Peptides and Activities
- IL-33, ST2, and ILC Pathways
- Reproductive System and Pregnancy
- Retinal Development and Disorders
- Aquaculture disease management and microbiota
- Bone health and treatments
- Chronic Lymphocytic Leukemia Research
- Glioma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
Chiba University
2016-2025
Komatsu (Japan)
2022
Loyola University Chicago
2009-2018
Augusta University
2006-2009
Bipar
2009
Mie University
2004-2005
The omentum is a sheet-like tissue attached to the greater curvature of stomach and contains secondary lymphoid organs called milky spots. has been used for its healing potential over 100 years by transposing omental pedicle injured (omental transposition), but mechanism which helps process damaged tissues not well understood. Omental transposition promotes expansion pancreatic islets, hepatocytes, embryonic kidney, neurons. cells (OCs) can be activated foreign bodies in vivo. Once...
The role of invariant natural killer T (iNKT) cells in antitumor immunity has been studied extensively, and clinical trials patients with advanced cancer have revealed a prolonged survival some cases. In recent years, humanized blocking antibodies against co-stimulatory molecules such as PD-1 developed. enhancement cell function is reported to improve immunity, leading positive effects. However, there are limited data on the PD-1/programmed death ligand (PDL) human iNKT cells. this study, we...
Background Invariant natural killer T (iNKT) cells produce copious amounts of cytokines in response to specific glycolipid antigens such as α-galactosylceramide (αGalCer) presented by CD1d-expressing antigen-presenting (APCs), thus orchestrating other immune fight tumors. Because their ability induce strong antitumor responses activated αGalCer, iNKT have been studied for application cancer immunotherapy. In our previous phase I/II trial non-small cell lung (NSCLC) patients who had completed...
ABSTRACT While antibody‐dependent cellular cytotoxicity (ADCC) by anti‐disialoganglioside GD2 monoclonal antibody (mAb) has succeeded in increasing the survival rate of high‐risk patients with neuroblastoma, approximately 40%–50% die from disease. Recently, we developed induced pluripotent stem cell‐derived natural killer T (iPS‐NKT) cells, which exhibit NK‐like cytotoxicity. However, whether iPS‐NKT cells can induce ADCC function is unclear. Here, investigated and efficacy combination...
Abstract Glioblastoma is the most common and aggressive type of brain tumor with high recurrence fatality rates. Although various therapeutic strategies have been explored, there currently no effective treatment for glioblastoma. Recently, number immunotherapeutic has tested malignant tumors. Invariant natural killer T (iNKT) cells play an important role in anti-tumor immunity. To address if iNKT can target glioblastoma to exert activity, we assessed expression CD1d, antigen-presenting...
Abstract Naturally arising CD4+CD25+FoxP3+ regulatory T cells (nTregs) have an essential role in maintenance of immune homeostasis and peripheral tolerance. Previously, we reported that conventional CD4+ CD8+ undergo p53-induced CD28-dependent apoptosis (PICA) when stimulated with a combination immobilized anti-CD3 anti-CD28 Abs, whereas nTregs expand robustly under the same conditions, suggesting there is differential survival mechanism against PICA between nTregs. In this study,...
Anti‐ganglioside GD2 antibodies mainly work through antibody‐dependent cellular cytotoxicity (ADCC) and have demonstrated clinical benefit for children with neuroblastoma. However, high‐risk neuroblastoma still has a high recurrence rate. For further improvement in patient outcomes, ways to maximize the cytotoxic effects of anti‐GD2 therapies minimal toxicity are required. Activated invariant natural killer T (iNKT) cells enhance both innate type I acquired anti‐tumor immunity by producing...
The immunoregulatory functions of vitamin D have been well documented in various immunological disorders, including multiple sclerosis, arthritis, and asthma. IL-10 is considered a chief effector molecule that promotes the D-induced immunosuppressive states T cells accessory cells. In this article, we demonstrate active form D, 1,25-dihydroxyvitamin D3 (calcitriol), has profound inhibitory effect on development human Th9, CD4 cell subset highly associated with asthma, an IL-10-independent...
Invariant natural killer T (iNKT) cells play an essential role in antitumor immunity by exerting cytotoxicity and producing massive amounts of cytokines. iNKT express invariant T-cell receptors (TCR) to recognize their cognate glycolipid antigens such as α-galactosylceramide (α-GalCer) presented on CD1d. We recently reported that CD1d-negative leukemia cell line K562 a TCR-dependent manner. However, it remains controversial how use TCRs exhibit cytotoxic activity toward tumors without CD1d...
Ag receptor stimulation of preactivated T cells causes rapid cell death in an IL-2- and Fas-dependent manner. This phenomenon, known as activation-induced (AICD), plays a pivotal role the removal Ag-reactive after initial expansion. In this study, we report novel form apoptosis that is distinct from classic AICD. When peripheral were activated with anti-CD3 anti-CD28 Abs precoated onto plastic plates, CD4(+)CD25(-) CD8 initially expanded but underwent massive 4 d. Unlike AICD, type pathway...
Invariant natural killer T (iNKT) cells are innate-like CD1d-restricted that express the invariant cell receptor (TCR) composed of Vα24 and Vβ11 in humans. iNKT specifically recognize glycolipid antigens such as α-galactosylceramide (αGalCer) presented by CD1d. show direct cytotoxicity toward CD1d-positive tumor cells, especially when CD1d presents antigens. However, recognition CD1d-negative is unknown, remains controversial. Here, we demonstrate activated leukemia a CD1d-independent...
Dendritic cells ( DC ) play a key role in the initiation of both antitumor immunity and immunological tolerance. It has been demonstrated that exposure to soluble factors produced by tumor modulates functions induces tolerogenic differentiation. In this study, we investigated effects neuroblastoma cell line‐derived on Monocytes isolated from healthy volunteers were incubated with interleukin IL )‐4 granulocyte‐macrophage colony‐stimulating factor presence culture supernatants lines. The...
Abstract The role of immune checkpoint inhibitors in metastatic lung cancer has been established recent years and the pretherapeutic profiles tumor microenvironment responders have increasingly reported. salvage surgery posttherapeutic specimens patients achieving an objective response rarely studied. We report a case treated by anti‐programmed death‐1 Ab followed surgical resection. status was assessed, showing germinal center formation, memory B cell infiltration, high frequency interferon...
Abstract Thymus‐derived regulatory T cells (tTregs) play pivotal roles in immunological self‐tolerance and homeostasis. A majority of tTregs are reactive to self‐antigens constantly exposed antigenic stimulation. Despite this continuous stimulation, tTreg conventional T‐cell populations remain balanced during homeostasis, but the mechanisms controlling balance unknown. We previously reported a form activation‐induced cell death, which is dependent on p53 (p53‐induced CD28‐dependent...
Internal hernias are rare after laparoscopic colorectal resections. We report a patient with an internal hernia through defect in the transverse mesocolon following resection. A 52-year-old male underwent colectomy for colon cancer and had unremarkable postoperative course. Thirty days postoperatively, he presented to emergency room sudden onset abdominal pain vomiting. Enhanced computed tomography scan showed strangulated small intestine left upper abdomen. An mesenteric created during...
<div>Abstract<p>Invariant natural killer T (iNKT) cells play an essential role in antitumor immunity by exerting cytotoxicity and producing massive amounts of cytokines. iNKT express invariant T-cell receptors (TCR) to recognize their cognate glycolipid antigens such as α-galactosylceramide (α-GalCer) presented on CD1d. We recently reported that CD1d-negative leukemia cell line K562 a TCR-dependent manner. However, it remains controversial how use TCRs exhibit cytotoxic activity...