A5089017230- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Neutropenia and Cancer Infections
- Chemotherapy-related skin toxicity
- Cancer Treatment and Pharmacology
- Radiopharmaceutical Chemistry and Applications
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Cancer therapeutics and mechanisms
- Colorectal and Anal Carcinomas
- Cardiovascular and exercise physiology
- Blood disorders and treatments
- Dental materials and restorations
- Oral health in cancer treatment
- Endodontics and Root Canal Treatments
- Gastrointestinal Tumor Research and Treatment
- Head and Neck Surgical Oncology
- Multiple Myeloma Research and Treatments
- Hematological disorders and diagnostics
- Breast Lesions and Carcinomas
- Metastasis and carcinoma case studies
- Colorectal Cancer Surgical Treatments
- Blood transfusion and management
Shiga University of Medical Science Hospital
2020-2024
Shiga University of Medical Science
2023-2024
Hiroshima University
2019-2023
Tokyo Dental College Ichikawa General Hospital
2023
Kure Medical Center
2015-2023
National Hospital Organization
2015-2023
Weatherford College
2023
Toyota Kosei Hospital
2023
Hiroshima University Hospital
2021-2022
National Museum of Nature and Science
2022
Esophageal adenoid cystic carcinoma (EACC) is a very rare form of malignant tumor in the esophagus. Here, we report case 78-year-old man who was diagnosed with EACC by preoperative endoscopic biopsy. Thoracoscopy-assisted subtotal esophagectomy lymph node dissection carried out. Microscopic examination resected specimen suggested that invaded to submucosal layer and showed no metastasis. Histologically, primarily exhibited an alveolar solid pattern partial cribriform tubular patterns. Alcian...
OBJECTIVE. The aim of this study was to assess the diagnostic performance dual-phase 18F-FDG PET/CT in detecting axillary lymph node metastasis patients with breast cancer. MATERIALS AND METHODS. A total 826 cancer were retrospectively evaluated. scans performed 1 hour and 2 hours after FDG administration before treatment. maximum standardized uptake value (SUVmax) at both time points (hereafter referred as SUVmax1 SUVmax2, respectively) retention index (RI) calculated. RESULTS. Axillary...
Chemotherapy-induced peripheral neuropathy (CIPN) is a serious side effect of weekly paclitaxel-based chemotherapy for breast cancer, that can persist years. Cryotherapy therapy effective preventing early CIPN, but its protective on persistent CIPN uncertain. This cross-sectional study conducted as an ancillary analysis randomized trial investigating the preventive cryotherapy in cancer patients receiving (UMIN000034966). Eligible were evaluated at more than year after completion (persistent...
To investigate whether tumor-infiltrating lymphocyte (TIL) scoring based on 18F-fluorodeoxyglucose positron-emission tomography/computed tomography (FDG PET/CT) can predict the pathological response to neoadjuvant chemotherapy.A total of 261 patients with breast cancer underwent complete resection after chemotherapy. PET-TIL score was calculated using tumor size, Ki-67 labeling index, and maximum standardized uptake value (SUVmax) FDG PET/CT. The efficacy in predicting (pCR) retrospectively...
Dental microwear analysis is an oft-used paleodietary estimation method, and the impression molds or resin casts are often analyzed rather than original tooth surfaces. A choice of silicone products for dental impressions crucial because quality data affected by accuracy molds. For this reason, researchers have heavily depended on a few commercial such as “President” (Coltène/Whaledent AG, Switzerland) to avoid analytical errors caused using different materials. Considering that production...
Immune checkpoint inhibitors (ICIs) have been widely used as standard therapies for various cancers. However, in 20–30% of cases, ICIs can lead to immune-related adverse events (irAEs), which sometimes require discontinuation treatment. Due the increased risk irAEs, patients with pre-existing autoimmune diseases (AI) are often advised against receiving ICIs. there has not sufficient objective assessment AI. In our study, we conducted logistic regression analysis assess irAEs by analyzing 478...
Clozapine, an atypical antipsychotic agent, has been reported to cause acute hyperglycemia. However, the mechanism of clozapine-induced rapidly developing hyperglycemia is not well elucidated. To clarify underlying hyperglycemia, we investigated effects single intravenous administration clozapine on serum concentrations glucose and several endogenous substances in rats. Male Wistar rats received injection saline (control) or 2.5, 5, 10 mg/kg. Blood samples were obtained periodically after...
Aim: To investigate the usefulness of classification ring-type dedicated breast positron-emission tomography (dbPET) findings in detection cancer. Patients and Methods: A total 709 patients with cancer underwent dbPET before treatment. Each finding was morphologically categorized as a focus (uptake size ≤5 mm), mass (>5 or non-mass (multiple uptakes not belonging to three-dimensional without distinct features). Non-mass were additionally classified linear, focal, segmental, regional,...
The maximum standardized uptake value (SUVmax) obtained using 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed (CT) is presumed to indicate tumor and active immune cells in the microenvironment (TIME) based on their glycolysis activity. Therefore, this study investigated whether metabolic parameter SUVmax could provide information regarding TIME triple-negative breast cancer (TNBC) patients.Fifty-four patients with TNBC underwent FDG PET/CT before neoadjuvant...
Objective We aimed to clarify the burden of vertigo in patients’ homes. Methods This was a questionnaire survey among patients with vestibular vertigo. Four main questions were prepared. Q1: Where did you first notice vertigo? Q2: have had most difficulty your home? Q3: do at present? Q4: What household equipment used as countermeasure prevent further problems Results Sixty completed questionnaire. Benign paroxysmal positional (BPPV) common respondents, followed by Ménière’s disease. Most...
Background: There are no universal tools to predict the necessity of high-dose opioid use for cancer-related pain. Early recognition and interventions intractable cancer pain could minimize distress palliative patients. Objective: We sought identify clinical factors associated with in advanced patients recognize who would develop pain, as early possible. Setting/Subjects: Among 385 in-hospital from April 1, 2014 July 31, 2019, were referred care team significantly correlated retrospectively...
The in vitro inhibitory effects of 12 quinolones, including clinically available compounds such as nalidixic acid, ofloxacin and enoxacin, on the murine hematopoietic progenitor cells topoisomerase II fetal calf thymus were compared. quinolones tested inhibited proliferation a dose-dependent manner, cytotoxicity correlated well (r = 0.910) with their potency against II.
Docetaxel and cyclophosphamide (TC) combination therapy is widely used as adjuvant chemotherapy for early-stage breast cancer associated with a high incidence of febrile neutropenia (FN). Granulocyte colony-stimulating factor (G-CSF) recommended in the primary prevention This study aimed to evaluate FN-suppressing effect G-CSF patients receiving TC.We performed 272 treatment cycles after FN onset 106 TC. We retrospectively evaluated secondary prophylaxis. The frequency was calculated based...
Abstract Background Chemotherapy-induced peripheral neuropathy (CIPN) is an important adverse event of taxane-based chemotherapy, which can persist in a substantial proportion patients for years. Cryotherapy therapy shown to be effective prevention CIPN during but its protective effect on persistent has not been reported. Methods This observational study was performed as ancillary analysis randomized trial investigating the preventive cryotherapy weekly paclitaxel-induced breast cancer...