A5101457926- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- T-cell and Retrovirus Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inhalation and Respiratory Drug Delivery
- Vector-Borne Animal Diseases
- Immune Response and Inflammation
- Vector-borne infectious diseases
- Animal Disease Management and Epidemiology
- Medical Imaging and Pathology Studies
- Pediatric health and respiratory diseases
- Myasthenia Gravis and Thymoma
- Particle accelerators and beam dynamics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Plasma Diagnostics and Applications
- Cell Adhesion Molecules Research
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Nitric Oxide and Endothelin Effects
- Allergic Rhinitis and Sensitization
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Hormonal Regulation and Hypertension
- Neuroscience of respiration and sleep
Kobe University
2024
Juntendo University
2023-2024
Meiji (Japan)
2019-2022
Kanazawa Medical University
1996-2020
National Hospital Organization
2006-2019
Ehime University
2018-2019
Juntendo University Urayasu Hospital
2019
Rakuno Gakuen University
1979-2018
Hokusei Gakuen University
2018
Tokyo Metropolitan Matsuzawa Hospital
2016
Objectives: Despite high smoking rates, few prevalence studies of COPD have been performed in Asia. The Nippon Epidemiology (NICE) Study used spirometry to measure airflow limitation Japanese adults. Methodology: Clinical, spirometric, and risk factor exposure data were collected on 2343 subjects aged ≥ 40 years who demographically similar the population. Airflow was defined according Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria (FEV 1 /FVC < 70%). Results:...
The cyclin-dependent kinase (cdk) inhibitor, p57 Kip2 is a tumour suppressor candidate and paternally-imprinted gene. In humans, the p57Kip2 gene located on chromosome 11p15.5, region implicated in both sporadic cancers Beckwith–Wiedemann syndrome. From analysis of p57Kip2-deficient mice, we demonstrate relationship between trophoblastic abnormalities p57Kip2. Both null (–/–) embryos heterozygous with maternally-derived mutated allele (+*/–) displayed placentomegaly, as well dysplasia...
Calorie restriction (CR) can modulate the features of obesity-related metabolic and cardiovascular diseases. We have recently characterized DahlS.Z-Lepr(fa)/Lepr(fa) (DS/obese) rats, derived from a cross between Dahl salt-sensitive Zucker as new animal model syndrome. DS/obese rats develop hypertension manifest left ventricular remodeling diastolic dysfunction, well increased cardiac oxidative stress inflammation. now investigated effects CR on pathophysiology in rats. were fed either normal...
A new miniature multiturn time-of-flight (TOF) analyzer “MULTUM-S II” has been designed and constructed. This instrument consists of an electron ionization source, the TOF ion optics, a detector, vacuum system, electronic circuits. The four electrostatic toroidal sectors two additional electric for purpose injection/ejection. size weight system is less than 50 cm × 57 30 35 kg (including pumps circuits). capable high mass resolution because its infinite flight path utilizing perfect space...
ABSTRACT In order to utilize upstream chum salmon as a component of nutraceutical food, their defatted muscle proteins were hydrolyzed with 5% thermolysin. The resulting hydrolysate showed high inhibitory activity against angiotensin I‐converting enzyme (inhibitory concentration 50 = 27.9 protein μg/mL) in vitro. A significant reduction systolic blood pressure was observed when 500 and 2000 mg/kg body weight orally administered into spontaneously hypertensive rats. Angiotensin peptides...
Abstract Background Rhinitis is a common disease, and its prevalence increasing worldwide. Several studies have provided evidence of strong association between asthma rhinitis. Although smoking obesity been extensively analyzed as risk factors asthma, associations with rhinitis are less clear. Objective The aims our study were (i) to evaluate the using E uropean C ommunity R espiratory H ealth S urvey ( ECRHS ) questionnaire in J apanese adults (ii) body mass index BMI Methods Following...
We describe three adult siblings with communicating hydrocephalus, corneal opacities, deafness, valvular heart disease, and deformed toes associated glucosylceramide (glc-cer)-β-glucosidase deficiency. The common manifestations of Gaucher disease were not evident. Supranuclear gaze palsies characteristic type 3 noted from early childhood, although the major signs undeveloped until life. Autopsy disclosed thickened leptomeninges perivascular fibrosis, non-rheumatic calcified aortic mitral...
We developed five different hybridoma cell lines that produced mAb against human monocyte chemoattractant protein-1 (MCP-1). The subclass of all antibodies was IgG1. All formed complexes with metabolically labeled MCP-1 could be demonstrated by immunoprecipitation. were specific for MCP-1. They did not cross-react immunoprecipitation structurally related host defense cytokines present in PHA- or LPS-stimulated mononuclear culture fluids, nor they a direct ELISA neutrophil...
To study the mechanisms responsible for ischemia-reperfusion lung injury, we developed an anesthetized rabbit model in which effects of deflation, inflation, alveolar gas composition, hypothermia, and neutrophils on reperfusion pulmonary edema could be studied. Rabbits were ventilated, left hilum was clamped either 2 or 4 h. Next, reperfused ventilated with 100% oxygen. As indexes measured arterial oxygenation, extravascular water, influx a vascular protein ( 131 I-labeled albumin) into...
Three monoclonal antibodies, designated RM-1, TRPM-1, and TRPM-2, were raised against rat peritoneal macrophages. By the immunoperoxidase method, antigens recognized by these antibodies distributed throughout most tissue free macrophages examined, including those of splenic red pulp, lymphatic sinus, connective tissue, cavity, as well Kupffer cells liver alveolar The numbers positive different for each antibody. RM-1 TRPM-1 also reactive with interdigitating (IDCs) in thymus-dependent area...