A5054024599- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory and Cough-Related Research
- Lipid Membrane Structure and Behavior
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Medical Imaging and Pathology Studies
- Allergic Rhinitis and Sensitization
- Sarcoidosis and Beryllium Toxicity Research
- Photoreceptor and optogenetics research
- Receptor Mechanisms and Signaling
- Lung Cancer Treatments and Mutations
- Mast cells and histamine
- Neonatal Respiratory Health Research
- Food Allergy and Anaphylaxis Research
- IL-33, ST2, and ILC Pathways
- Nanopore and Nanochannel Transport Studies
- Inhalation and Respiratory Drug Delivery
- Drug-Induced Adverse Reactions
- Orbital Angular Momentum in Optics
- Eosinophilic Disorders and Syndromes
- Congenital Diaphragmatic Hernia Studies
- Force Microscopy Techniques and Applications
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Eosinophilic Esophagitis
Osaka Metropolitan University
2023-2025
Tokyo Metropolitan University
2023-2025
Okayama Medical Center
2005-2024
National Hospital Organization
2005-2024
Okayama University Hospital
2011-2023
Kobe University
2014-2023
Okayama University
2005-2015
Hyogo University
2013
ENT and Allergy
2011
Okayama Shoka University
2011
Abstract Background Pulmonary emphysema is characterized by alveolar destruction and persistent inflammation of the airways. Although IL-17A contributes to many chronic inflammatory diseases, it’s role in response elastase-induced remains unclear. Methods In a model pulmonary we examined IL-17A-deficient mice, monitoring airway inflammation, static compliance, lung histology levels neutrophil-related chemokine pro-inflammatory cytokines bronchoalveolar lavage (BAL) fluid. Results Wild-type...
<i>Background:</i> Asthma is a common respiratory disease worldwide. However, few reports are available on the prevalences of asthma and symptoms among Asian subjects. <i>Methods:</i> To determine Japanese subjects, we performed nationwide cross-sectional, population-based study adults aged 20–79 years. Ten areas spread throughout country were randomly selected. Door-to-door or postal surveys using translated version European Community Respiratory Health Survey...
Abstract Background Chronic asthma is often associated with neutrophilic infiltration in the airways. Neutrophils contain elastase, a potent secretagogue airways, nonetheless role for neutrophil elastase as well inflammation allergen-induced airway responses not defined. In this study, we have investigated impact of inhibition on development allergic and hyperresponsiveness (AHR) previously sensitized challenged mice. Methods BALB/c mice were (primary) ovalbumin (OVA). Six weeks later,...
In biological membranes, lipids and proteins interact with each other to regulate their functions complex structure. Manipulation techniques of molecular dynamics are desired elucidate the regulation mechanism mediated by interaction membrane molecules. Optical trapping has been applied study since it allows manipulation biomolecules labeled single μm-sized particle at laser focal spot in solution. Due structure weak optical forces, is difficult investigate effects on molecules membrane....
In recent years, nanostructures created using optical vortices have attracted much attention. However, the details of nanostructure formation process not yet been clarified. this study, focusing on formed by Laguerre-Gaussian beam irradiation, we investigated assembly dynamics nanoparticles (NPs) as a model to understand chiral nanostructures. Analyzing fluorescence intensity and areas at laser focal spot, evaluated assembled structure NPs. Furthermore, particle tracking analysis for NPs...
Decades of research in the field tissue engineering have allowed important findings to control cellular behaviors lab by designing artificial scaffolds. However, it is still challenging engineer tissues (i.e. cell collectives with specific functions) that intrinsic functions equivalent those our body. One key element building such advanced functional understanding structure-cellular function correlations. Specifically, helical structures are seen many body, as structure skeletal muscle...
Risk factors for the development of interstitial lung disease in patients with non-small cell cancer receiving gefitinib and prognostic after have not been established. The aim this study was to retrospectively identify evaluate these possible factors. PATIENTS AND METHODS We reviewed clinical records radiographs 365 consecutive who received West Japan between 2000 2003. RESULTS In total, 330 were eligible evaluation, 15 (4.5%) finally confirmed developed by blinded expert review....
We investigated the therapeutic potential of a newly developed antifibrotic agent, pirfenidone, to regulate airway remodeling and development allergic inflammation hyperresponsiveness after chronic allergen challenge. Administration pirfenidone sensitization but during period ovalbumin challenge significantly prevented eosinophil lymphocyte accumulation in airways. IL-4, IL-5, IL-13 levels bronchoalveolar lavage fluid ovalbumin-specific serum IgE antibody were also reduced. Treatment with...
Abstract Background Rhinitis is a common disease, and its prevalence increasing worldwide. Several studies have provided evidence of strong association between asthma rhinitis. Although smoking obesity been extensively analyzed as risk factors asthma, associations with rhinitis are less clear. Objective The aims our study were (i) to evaluate the using E uropean C ommunity R espiratory H ealth S urvey ( ECRHS ) questionnaire in J apanese adults (ii) body mass index BMI Methods Following...
Evaluation of airway inflammation is important for the diagnosis and treatment asthma. Exhaled breath condensate (EBC) a minimally invasive method assessing may be useful monitoring in The aims this study were to establish an EBC collection method, assess biomarkers reflecting asthmatic inflammation, determine relationship these with asthma severity lung function.Fifty-eight non-smoking healthy subjects, seven asymptomatic smokers, nine subjects common cold 55 asthmatics disease ranging from...
The purpose of this study is to determine the relationship ocular adnexal benign or reactive lymphoid hyperplasia, including orbital pseudotumor, with immunoglobulin G4 (IgG4)-related diseases. Medical charts 9 consecutive patients lesions, seen in Department Ophthalmology, Okayama University Hospital, were reviewed, and pathological sections restained immunohistochemically for IgG4-, IgG-, CD138-positive plasma cells. diagnosis IgG4-positive lesions was based on 10 more cells a high-power...
We describe a case of 63-year-old woman with pulmonary artery sarcoma successfully treated chemotherapy. She developed acute shortness breath, and left chest shoulder pain. Although diagnosis embolism was made at local hospital she received anticoagulation thrombolysis therapy, no improvement achieved. Thereafter, underwent thromboectomy in our hospital, the histological intimal artery. Since post-operative computed tomography (CT) scans showed obvious persistence an intraluminal...
A 56yearold woman was admitted to our hospital for treatment of nonspecific interstitial pneumonitis (NSIP). The patient started prednisone treatment, but one month later with voglibose, an αglucosidase inhibitor (αGI), because prednisoneinduced diabetes mellitus. One week later, a massive volume free air below the diaphragm detected by chest Xray examination. An abdominal CT examination demonstrated pneumatosis coli and diagnosed cystoides intestinalis (PCI). Voglibose discontinued...
The incidence of overlapping bronchial asthma and chronic obstructive pulmonary disease has increased in recent years. Cysteinyl leukotrienes (CysLTs) play an important role asthma, the type 1 CysLT receptor (CysLT1R) is expressed by many inflammatory cells. We evaluated effect montelukast, a CysLT1R antagonist, on mouse models porcine pancreatic elastase (PPE)-induced emphysema, combined with emphysema. Mice were sensitized ovalbumin (OVA) Days 0 14 subsequently challenged OVA 28, 29, 30....
Abstract Rhodopsin is a G protein-coupled receptor (GPCR) that initiates the phototransduction cascade in retinal disc membrane. Recent studies have suggested rhodopsin forms highly ordered rows of dimers responsible for single-photon detection by rod photoreceptors. Dimerization also known to confer high affinity lipids (raftophilicity). However, role organization and its raftophilicity remains obscure, owing lack direct observation dynamics distribution native discs. Here, we explore...
Asthma is a heterogeneous disease, and phenotyping can facilitate understanding of disease pathogenesis direct appropriate asthma treatment. This nationwide cohort study aimed to phenotype patients in Japan identify potential biomarkers classify the phenotypes.Adult (n = 1925) from 27 national hospitals were enrolled divided into Global Initiative for (GINA) steps 4 or 5 (GINA 4, 5) GINA Steps 1, 2, 3 1-3) therapy. Clinical data questionnaires collected. Biomarker levels among measured....
Background: Dupilumab is a fully humanized monoclonal antibody that blocks interleukin-4 and interleukin-13 signals. Several large clinical trials have demonstrated the efficacy of dupilumab in patients with severe asthma. However, few studies examined switch to from other biologics. Methods: This retrospective, multi-center observational study was conducted by Okayama Respiratory Disease Study Group. Consecutive asthma who were switched biologics without treatment interval between May 2019...
Basophil chemotactic activity (BCA) of eight recombinant human (rh) cytokines was examined. Highly purified basophils were obtained by Percoll discontinuous gradients, followed negative selection using flow cytometry. Then BCA measured means modified Boyden chamber method. Both interleukin (IL)-3 and granulocyte-macrophage colony-stimulating factor (GM-CSF) had much more potent than complement C5a, leukotriene B4 platelet activating factor, well known as granulocyte factors. Chemotaxis...