A5088506886- Epigenetics and DNA Methylation
- Genetic factors in colorectal cancer
- Image and Signal Denoising Methods
- Colorectal Cancer Screening and Detection
- EEG and Brain-Computer Interfaces
- Image Processing Techniques and Applications
- Industrial Vision Systems and Defect Detection
- Advanced Image Processing Techniques
- Muscle activation and electromyography studies
- Transcranial Magnetic Stimulation Studies
- Colorectal Cancer Surgical Treatments
- Acupuncture Treatment Research Studies
- Image Enhancement Techniques
- Complementary and Alternative Medicine Studies
- Folate and B Vitamins Research
- Motor Control and Adaptation
- Health and Wellbeing Research
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Health, psychology, and well-being
- Viral Infections and Vectors
- Functional Brain Connectivity Studies
- Digestive system and related health
- Mosquito-borne diseases and control
- Advanced Image Fusion Techniques
The University of Tokyo
1995-2024
University of Electro-Communications
2020-2022
Tokyo Ariake University of Medical and Health Sciences
2012-2022
Gifu University
2021-2022
Saku Central Hospital
2020-2022
Kanagawa Institute of Technology
2008-2021
Kyoto Sangyo University
2021
Saitama Institute of Technology
2021
Saitama University
2021
Bandung Institute of Technology
2021
Altered expression of microRNA (miRNA) is strongly implicated in cancer, and recent studies have shown that the silencing some miRNAs associated with CpG island hypermethylation. To identify epigenetically silenced gastric cancer (GC), we screened for induced by treatment 5-aza-2'-deoxycytidine 4-phenylbutyrate. We found miR-34b miR-34c are GC their downregulation hypermethylation neighboring island. Methylation miR-34b/c was frequently observed cell lines (13/13, 100%) but not normal mucosa...
OBJECTIVES: Sessile serrated adenomas (SSAs) are known to be precursors of sporadic colorectal cancers (CRCs) with microsatellite instability (MSI), and tightly associated withBRAFmutation the CpG island methylator phenotype (CIMP). Consequently, colonoscopic identification SSAs has important implications for preventing CRCs, but accurate endoscopic diagnosis is often difficult. Our aim was clarify which findings specific SSAs. METHODS: The morphological, histological molecular features 261...
The Lys mutation of the canonical histone H3.1 Glu97 residue (H3E97K) is found in cancer cells. Previous biochemical analyses revealed that nucleosome containing H3E97K extremely unstable as compared to wild-type nucleosome. However, mechanism by which causes instability has not been clarified yet. In present study, cryo-electron microscopy structure entry/exit DNA regions are disordered, probably detachment nucleosomal from H3 N-terminal regions. This may change intra-molecular amino acid...
To determine the type, severity, and incidence of acupuncture adverse reactions that are observed in standard practice.A survey based on observation interview by therapists.Tsukuba College Technology Clinic Japan.All patients who underwent treatment during a period 4 months from April to July 1998.Type, reactions.A total 391 were treated 1,441 sessions, involving 30,338 needle insertions. The recorded systemic individual was: tiredness (8.2%); drowsiness (2.8%); aggravation preexisting...
<i>Background:</i> Asthma is a common respiratory disease worldwide. However, few reports are available on the prevalences of asthma and symptoms among Asian subjects. <i>Methods:</i> To determine Japanese subjects, we performed nationwide cross-sectional, population-based study adults aged 20–79 years. Ten areas spread throughout country were randomly selected. Door-to-door or postal surveys using translated version European Community Respiratory Health Survey...
Metachronous gastric cancer (GC) can develop after endoscopic resection of GC and cannot be predicted based on clinical signature. Aberrant DNA methylation in noncancerous mucosa is strongly implicated carcinogenesis could a useful biomarker risk. We evaluated the utility as metachronous carried out scheduled follow-up endoscopy 129 patients curative GC. Biopsy specimens were collected from antrum body, which quantitative analysis miR-34b/c, SFRP1, SFRP2, SFRP5, DKK2 DKK3 was using bisulfite...
Objectives In recent years the retractable type of sham needle has been anticipated to be a possible solution for masking patients in acupuncture research. However, this intended mainly acupuncture-naïve subjects. The authors' goal study was assess validity needle. Methods authors conducted two randomized, single-blind, crossover trials with acupuncture-experienced Different points were used each trial (a LI-4 and BL-23 trial). subjects received sessions different stimulations trial. A Park...
Abstract Although conventional colonoscopy is considered the gold standard for detecting colorectal tumors, accurate staging often difficult because advanced histology may be present in small lesions. We collected DNA mucosal wash fluid from patients undergoing and then assessed methylation levels of four genes frequently methylated cancers to detect invasive tumors. found that were significantly higher with than those noninvasive Cytologic K-ras mutation analyses suggested tumors contained...
Aberrant DNA methylation could potentially serve as a biomarker for colorectal neoplasms. In this study, we assessed the feasibility of using detected in bowel lavage fluid (BLF) cancer screening. A total 508 BLF specimens were collected from patients with (n = 56), advanced adenoma 53), minor polyp 209), and healthy individuals 190) undergoing colonoscopy. Methylation 15 genes (miR-1-1, miR-9-1, miR-9-3, miR-34b/c, miR-124-1, miR-124-2, miR-124-3, miR-137, SFRP1, SFRP2, APC, DKK2, WIF1,...
People suffering from asthmatic symptoms have a lower quality of life than those without. The aim this study is to clarify the association with severity asthma, perceived stress, and other factors such as comorbidity allergic diseases among young adults asthma. participants were 695 asthma patients, aged 20-44 years, 29 medical centers in Japan. We excluded analysis result 116 patients complications serious diseases, cough-variant or aspirin-intolerant completed 8-Item Short-Form Health...
Aberrant DNA methylation is implicated in the epigenetic field defect seen gastric cancer. Our aim this study was to identify predictive biomarkers by screening for noncancerous background mucosa from patients with Using methylated-CpG island amplification coupled CpG microarray (MCAM) analysis, we identified 224 genes that were methylated of Among them, RASGRF1 significantly elevated either intestinal or diffuse type cancer, as compared healthy individuals (8.3% vs. 22.4%, P < 0.001; 8.3%...
Orchestrating cortical network activity with synchronous oscillations of neurons across distant regions the brain underlies information processing in humans (Knight, 2007) and monkeys (Saalmann et al., 2007; Womelsdorf 2007). Frequencies oscillatory activities depend, to a considerable extent, on length conduction velocity tracts connecting neural areas that participate (Buzsáki, 2006). However, impulse propagation along fiber white matter has never been visualized humans. Here, we show, by...
// Seiko Kamimae 1, * , Eiichiro Yamamoto 2, Masahiro Kai Takeshi Niinuma 2 Hiro-o Yamano 3 Masanori Nojima 4 Kennjiro Yoshikawa Tomoaki Kimura Ryo Takagi Eiji Harada Taku 1 Reo Maruyama Yasushi Sasaki 5 Takashi Tokino Yasuhisa Shinomura Tamotsu Sugai 6 Kohzoh Imai 7 Hiromu Suzuki Department of Molecular Biology, Sapporo Medical University School Medicine, Sapporo, Japan Gastroenterology, Rheumatology, Clinical Immunology, Akita Red Cross Hospital, Akita, Center for Translational Research,...
MEG recordings visualized non-invasively a serial mediolateral activation of the human somatosensory 3b area followed by stationary 1 after median nerve stimulation. Somatosensory evoked fields (SEFs) were recorded over hand contralateral to right stimulation at wrist in six normal subjects. A newly developed vector beamformer technique applied SEFs revealed two distinct sources (areas and 1) primary cortex (SI) during N20m-P22m response all The first source was located 3b, which started...