A5100320184- Acupuncture Treatment Research Studies
- Healthcare and Venom Research
- Complementary and Alternative Medicine Studies
- Pain Management and Placebo Effect
- Osteoarthritis Treatment and Mechanisms
- Atrial Fibrillation Management and Outcomes
- Traditional Chinese Medicine Studies
- Rheumatoid Arthritis Research and Therapies
- Facial Nerve Paralysis Treatment and Research
- Cardiac Arrhythmias and Treatments
- Psychosomatic Disorders and Their Treatments
- Medical Research and Treatments
- Eosinophilic Disorders and Syndromes
- Leprosy Research and Treatment
- Immune Cell Function and Interaction
- Heart Rate Variability and Autonomic Control
- Myofascial pain diagnosis and treatment
- Vasculitis and related conditions
- Neuroscience and Neuropharmacology Research
- Cardiac tumors and thrombi
- Spondyloarthritis Studies and Treatments
- Vagus Nerve Stimulation Research
- Protease and Inhibitor Mechanisms
- Sarcoidosis and Beryllium Toxicity Research
- Musculoskeletal pain and rehabilitation
Kyung Hee University
2011-2024
Daegu Haany University
2024
Kyung Hee University East-West Neo Medical Center
2007-2024
Kyung Hee University Medical Center
2013-2024
Gwangju Institute of Science and Technology
2024
University of California, Irvine
2010-2023
Korea Brain Research Institute
2020
Inje University
2019
Pohang SeMyeong Christianity Hospital
2019
Kyung Hee University Hospital at Gangdong
2012-2018
Abstract Mutations that inactivate negative translation regulators cause autism spectrum disorders (ASD), which predominantly affect males and exhibit social interaction communication deficits repetitive behaviors. However, the cells ASD through elevated protein synthesis resulting from these mutations remain unknown. Here we employ conditional overexpression of initiation factor eIF4E to increase in specific brain cells. We show exaggerated microglia, but not neurons or astrocytes, leads...
Persistent CB<sub>1</sub> cannabinoid receptor activity limits neurotransmitter release at various synapses throughout the brain. However, it is not fully understood how constitutively active receptors, tonic endocannabinoid signaling, and its regulation by multiple serine hydrolases contribute to synapse-specific calibration of probability. To address this question perisomatic dendritic GABAergic in mouse hippocampus, we used a combination paired whole-cell patch-clamp recording, liquid...
Endocannabinoid-mediated retrograde synaptic signaling is a key regulator of GABA release at synapses formed on the perisomatic region pyramidal cells by basket that coexpress cannabinoid type 1 receptor (CB<sub>1</sub>R) and cholecystokinin (CCK). However, CB<sub>1</sub>R CCK-positive GABAergic terminals are present cell dendrites as well, but principles endocannabinoid control in not understood. We performed paired recordings from perisomatically (basket cells) or dendritically projecting...
This study was performed to evaluate the contribution of adiponectin production interleukin (IL)-6, IL-8, vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-1 and MMP-13 in human cells osteoblasts arthritic joints. Cultured umbilical (HUVECs) were stimulated with (1 or 10 μg ml(-1)) IL-1β (0.1 ng presence absence hypoxia for 24 h. The protein expression patterns examined by analyzing culture supernatants using enzyme-linked immunosorbent assay (ELISA). Adiponectin...
Abstract: The objectives of this study were (1) to develop a three‐dimensional chitosan scaffold in combination with transforming growth factor‐beta1 (TGF‐β1)‐loaded microspheres and (2) evaluate the effect TGF‐β1 release on chondrogenic potential rabbit chondrocytes scaffolds. was loaded into using an emulsion‐crosslinking method, resulting spherical shapes size ranging from 0.3 1.5 µm. Controlled TGF‐β1, as measured by enzyme‐linked immunosorbent assay (ELISA), observed over 7 days....
The PD-1 (programmed death 1) molecule is a negative regulator of T cells. PDCD1 cell has been reported to have genetic association in systemic lupus erythematosus and rheumatoid arthritis Caucasians. However, there are no reports on the between this gene ankylosing spondylitis (AS). present study investigated polymorphisms haplotypes with AS Korean population sample. In case-control study, two single-nucleotide polymorphisms, PD-1.5 C/T PD-1.9 T/C, were genotyped 95 patients 130 healthy...
Objectives. To further understand the expression regulation of MMP-1 and MMP-13 under physiological pathological conditions, we investigated combined effects hypoxia pro-inflammatory stimuli on in rheumatoid synovial fibroblasts. Methods. Synovial fibroblasts were cultured either hypoxic or normoxic conditions presence IL-1β stimulation. The culture supernatant was analysed for secreted levels VEGF, MMP-13. Their gene quantified with real-time semi-quantitative PCR. Another group cells...
Nonvitamin K antagonist oral anticoagulants (NOACs) require stricter medication adherence. We investigated the NOACs adherence in real-world practice. screened all patients our cardiology department day before their outpatient appointment, over a 5-month period. enrolled 719 consecutive who were taking for atrial fibrillation. The contacted by phone or text to bring remnant pills with them without any information why. Adherence was measured percentage of prescribed doses taken (PDT) (number...
Abstract In an attempt to develop antiinflammatory herbal remedy that is as potent current synthetic medicines, the cortex of Phellodendron amurense Rupr (Rutaceae) and rhizomes Coptis chinensis Franch (Ranunculaceae) were combined in a 2:1 ratio. This ratio was chosen based on vitro experiments traditional Asian medicine prescriptions. The ethanol extract, named RAH13, evaluated for properties using animal models acute inflammation such croton oil‐induced ear edema test acetic acid‐induced...
Primary dysmenorrhea is a common gynecological complaint among young women that related to an autonomic nervous system (ANS) disturbance. Acupuncture one of several therapeutic approaches for primary dysmenorrhea, since it can modulate ANS function. The heart rate variability (HRV) parameters such as high frequency (HF), low (LF) and LF/HF ratio are generally accepted tools assess activity. purpose this study was investigate the effects acupuncture applied at Hegu (LI4) Sanyinjiao (SP6)...
Acupuncture regulates inflammation process and growth factors by increasing blood circulation in affected areas. In this study, we examined whether acupuncture has an effect on wound healing injured rat. Rats were assigned randomly into two groups: control group group. treatment was carried out at 8 sites around the wounded area. We analyzed area, inflammatory cytokines, proliferation of resident cells, angiogenesis induction extracelluar matrix remodeling. At 7 days after-wounding size...
Abstract Background Neuropsychiatric symptoms, comprising cognitive impairment, fatigue, insomnia, depression, and anxiety, are prevalent may co-occur during after chemotherapy treatment for cancer. Electroacupuncture (EA), which involves mild electrical stimulation with acupuncture, holds great potential in addressing the management of individual symptoms. However, there is a lack studies evaluating if EA can manage concurrent neuropsychiatric symptoms cancer (i.e., symptom cluster). Hence,...
Abstract Background Allergic rhinitis is one of the most common health complaints worldwide. Complementary and alternative medical approaches have been employed to relieve allergic symptoms avoid side effects conventional medication. Acupuncture has widely used treat patients with rhinitis, but available evidence its effectiveness insufficient. Our objective evaluate acupuncture in Korea China persistent compared sham treatment or waitlist control. Methods This study consists a multi-centre...
WIN-34B is a novel Oriental medicine, which represents the n-butanol fraction prepared from dried flowers of Lonicera japonica Thunb and roots Anemarrhena asphodeloides BUNGE. The component herb used for arthritis treatment in East Asian countries. aim this study was to determine cartilage-protective effects mechanisms its major phenolic compounds, chlorogenic acid mangiferin, osteoarthritis (OA) human cartilage explants culture chondrocytes. investigation focused on whether standard...
This study was performed to evaluate whether endocan expression, which is known be involved in tumor angiogenesis, increased rheumatoid arthritic tissues. In addition, the involvement of adiponectin regulation expression joints examined. Arthritic synovial tissues from patients with arthritis (RA) or osteoarthritis (OA) were immunostained antibodies and vascular endothelial growth factor (VEGF). Subsequently, cells human umbilical vein cultured stimulated interleukin-1 β (IL-1β) adiponectin....
Objective: Bee venom has been reported to have antinociceptive and anti-inflammatory effects in experimental studies. However, questions still remain regarding the clinical use of bee venom. This report describes successful outcome treatment for refractory postherpetic neuralgia. Patient: A 72-year-old Korean man had severe pain hypersensitivity region where he developed a herpes zoster rash 2 years earlier. He was treated with antivirals, painkillers, steroids, analgesic patches, all no...
Abstract Background: Osteoarthritis (OA) is a degenerative disease that not only causes knee pain in older adults, but also has an adverse effect on walking. Therefore, intervention for patients with OA important. To investigate the immediate effects of kinesiology taping (KT) and gait function adults OA. Methods: This study enrolled 10 individuals living community who were diagnosed All participants assessed pain, walking ability, balance before after application KT. Knee was resting...
A nation-wide, outpatient-based, cross-sectional survey with the use of questionnaires.To evaluate pain, disability and satisfaction patients osteoporotic vertebral compression fractures (OVCFs).There are no nation-wide data in Korea on degree treatment OVCFs.We performed a 573 OVCFs. After excluding incomplete questionnaires (missing more than 30% variables), 430 patient-physician-matched sets were collected for this survey.Patients OVCFs managed conservative 63% vertebroplasty 37%. The...