A5042172701- Fibromyalgia and Chronic Fatigue Syndrome Research
- Rheumatoid Arthritis Research and Therapies
- Musculoskeletal pain and rehabilitation
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Autoimmune and Inflammatory Disorders Research
- Inflammatory Myopathies and Dermatomyositis
- Lymphoma Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Eating Disorders and Behaviors
- Skin Diseases and Diabetes
- Pain Mechanisms and Treatments
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Inflammasome and immune disorders
- Hereditary Neurological Disorders
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Otitis Media and Relapsing Polychondritis
- Biosimilars and Bioanalytical Methods
- Renin-Angiotensin System Studies
- Hepatitis C virus research
- Myofascial pain diagnosis and treatment
- Immunodeficiency and Autoimmune Disorders
- Antimicrobial Peptides and Activities
Konyang University
2013-2024
Konyang University Hospital
2006-2022
Ajou University Hospital
2018
Hanyang University Seoul Hospital
2003
Health-related quality of life (HRQOL) in patients with fibromyalgia (FM) is lower than other chronic diseases and the general population. Although various factors affect HRQOL, no study has examined a structural equation model HRQOL as an outcome variable FM patients. The present assessed relationships among physical function, social factors, psychological effects these variables on hypothesized using modeling (SEM).HRQOL was measured SF-36, Fibromyalgia Impact Questionnaire (FIQ) used to...
Patients with fibromyalgia (FM) exhibit significant clinical heterogeneity, in terms of physical, social and psychological functions, as well therapeutic responses. Here, we examined FM patients pain, variables to identify subgroups that may be predictive treatment patterns.A total 313 were interviewed using a structured questionnaire included sociodemographic data, current or past symptoms use relevant medications. A K-means cluster analysis was conducted reflecting tender points, the...
Objective. Guanosine triphosphate cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in synthesis of tetrahydrobiopterin, which an essential cofactor nitric oxide (NO) production. Polymorphisms GCH1 gene have been implicated protection against pain sensitivity. The aim our study was to determine whether single-nucleotide polymorphisms (SNP) affect susceptibility and/or sensitivity fibromyalgia syndrome (FM). Methods. A total 409 patients with FM and 422 controls were enrolled. alleles...
Objective. Researchers continue to gather evidence that transient receptor potential vanilloid (TRPV) channels contribute towards pain signalling pathways. However, it is unknown whether polymorphisms of the TRPV gene are associated with FM. For first time, we investigated association between TRPV2 and TRPV3 genes, FM susceptibility severity symptoms. Methods. A total 409 patients 423 controls were enrolled from 10 medical centres participated in Korean nationwide survey. The alleles...
Although polymorphisms of the catechol-O-methyl transferase (COMT) gene have been implicated in altered pain sensitivity, results concerning association between COMT and fibromyalgia (FM) are equivocal. We assessed associations single-nucleotide (SNP) FM risk symptom severity.In total, 409 patients 423 controls were enrolled. Alleles genotypes at five positions [rs6269 (A>G), rs4633 (C>T), rs4818 (C>G), rs4680 (C>G) rs165599 (A>G)] genotyped from peripheral blood DNA.Alleles polymorphism...
Objective: To determine whether HLA‐DR alleles are associated with the development and clinical features of systemic sclerosis (SSc) in Koreans.Methods: Seventy‐nine patients (74 women five men; 45 diffuse types 34 limited types; mean age at diagnosis 43.9 years) fulfilling American College Rheumatology (ACR) classification criteria for SSc were enrolled. The controls 144 healthy, disease‐free Koreans. HLA‐DRB1 genotypes assessed by polymerase chain reaction‐sequence specific oligonucleotide...
Several lines of evidence imply that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology fibromyalgia (FM); this regard, patients with FM have altered blood and cerebrospinal fluid levels BDNF. In study, we explored association between BDNF gene polymorphisms susceptibility severity symptoms. total, 409 423 healthy controls 10 medical centers were enrolled from Korean nationwide survey. The alleles genotypes at positions genotyped. allele genotype frequencies...
To determine characteristics of rheumatoid arthritis (RA) patients in Korea using disease-modifying anti-rheumatic drugs (DMARDs) for at least 6 months, and to identify factors associated with poor health-related outcomes.A total 2000 RA aged > 20 years, treated DMARDs signed informed consent, were enrolled this non-interventional, multicenter, cross-sectional observational study from December 2012 June 2013. Health-related quality life (HRQoL) was measured EuroQuol 5D (EQ-5D) functional...
This study aimed to detect signals of adverse drug reactions (ADRs) associated with biological disease-modifying antirheumatic drugs (DMARDs) and targeted therapies in rheumatoid arthritis (RA) ankylosing spondylitis (AS) patients. Utilizing the KOrean College Rheumatology BIOlogics & Targeted Therapy Registry (KOBIO) data, we calculated relative risks, excluded previously reported drug-ADR pairs, externally validated remaining pairs using US Food Drug Administration (FDA) Adverse Event...
Objectives: This study aims to investigate the role of cluster differentiation 14 (CD14) expressed monocytes and soluble CD14-mediated pathway in synovial inflammation knee osteoarthritis (OA). Patients methods: Between May 2012 July 2013, a total 35 patients with OA (9 males, 26 females; mean age: 66.3±8.8 years; range, 52 79 years) were included this cross-sectional study. Synovial fluid was obtained from joints patients. The CD14 + mononuclear cells (SFMCs) isolated using MACS....
To determine whether angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism is associated with the development and clinical features of systemic sclerosis (SSc) in Korean, we studied seventy two Korean patients SSc fulfilling ACR preliminary classification criteria. The controls were 114 healthy, disease free Koreans. ACE I/D genotypes determined by PCR method using oligonucleotides. Sixty eight (94.4%) women age at diagnosis was 43.5+/-12.6 yr old (mean+/-SD). Thirty...
Despite extensive studies, the pathogenesis of Behçet's disease (BD) remains unclear. In particular, roles B cells in patients with BD have not been elucidated. Activation-induced cytidine deaminase (AID) is a critical enzyme for immunoglobulin (Ig) heavy chain class switching and somatic hypermutation abnormal expression AID various immune conditions has previously studied. B10 cells, an interleukin (IL)-10-secreting subset regulatory function to downregulate inflammation autoimmunity....
To investigate correlations between myositis-specific autoantibodies (MSA) or myositis-associated antibodies (MAA) and clinical features, thereby demonstrating the utility of clinicoserologic classification in idiopathic inflammatory myopathies (IIM) patients.We conducted a multicenter study 108 adult patients (age ≥18 years) who were diagnosed with IIM by Peter Bohan criteria 2004 European Neuromuscular Centre (ENMC) criteria. Clinical data obtained medical record review. Immunoblot assay...
Objective Pathogenesis of Behçet's disease (BD) is known to be multifactorial and accumulating data suggest genetic mechanisms. Variations in nuclear DNAs have been largely investigated, while studies on mitochondrial are limited. The purpose the current study investigate associations single nucleotide polymorphisms haplotypes with BD. Methods Complete were sequenced using chip array blood samples collected from 20 patients 10 control subjects. Haplotypes searched hypervariable region 1 2....
This study aims to evaluate the frequency of tarsal tunnel syndrome (TTS) in fibromyalgia (FM) patients.In this prospective study, we investigated paresthesia foot, sensory and motor deficits, atrophy abductor hallucis muscle, presence Tinel's sign 76 female FM patients (mean age 39.3±7.4 years; range, 24 52 years) 60 sex-matched healthy control subjects 38.6±8.2 28 49 without between July 2016 June 2018. Bilateral electrophysiological studies tibial, peroneal, sural, medial as well lateral...
Thrombocytopenia is included in the classification criteria for systemic lupus erythematosus (SLE). However, severe thrombocytopenia causing spontaneous bleeding rare. Here, we describe a 22-year-old woman who presented with hemoperitoneum as first manifestation of SLE. Laboratory findings compatible SLE positive antinuclear antibody and false-positive venereal disease research laboratory. Symptoms suggesting were not prominent early after admission, but headache seizures that developed on...
Objective Productivity loss was compared by 3-stage of disease activity and associations between higher high productivity were identified. Methods Data extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥6-month) December 2012 to June 2013. This included 1,457 with the score (DAS-28-ESR) in their medical charts. time indirect cost estimated using The World Health...
Cytomegalovirus (CMV) is a relatively common viral patho-gen, and CMV infection generally assumed asymptomatic in general hosts. In immunologically compromised patients, can cause further serious diseases such as pneumonitis, retinitis, encephalitis, enterocolitis. A 40-year-old man being presented with acute fever, myal-gia, sore throat. Laboratory findings have revealed elevated ESR, CRP, ferritin levels. The patient was treated for adult-onset Still's disease (AOSD). Three weeks later,...
A key outcome of chronic antigenic stimulation in the setting sustained inflammation is development CD8<sup>+</sup> T cell exhaustion. However, relative roles and antigen on dysfunction remain unclear. Inborn errors immunity (IEIs) provide an opportunity to study effect genetic alterations signaling pathways immune function. Here, we focus IEI resulting from genetically amplified cytokine signaling: gain-of-function mutations STAT3 (STAT3 GOF). signals downstream multiple inflammatory...
Infection is a critical and challenging situation encoun-tered in treatment of inflammatory rheumatic diseases (IRDs). It associated with the disease activity itself and/or immunosuppressant treatments. Vaccine pre-ventable infections could be controlled by use timely vaccination protocol. Immunosuppressed situations observed IRDs require some modification recommendation for general population each national society. Live attenuated vaccines are generally contra-indicated IRDs, except...
Objective: Biologic disease-modifying antirheumatic drugs or targeted therapies have emerged as treatment categories in rheumatology. We aimed to detect signals of adverse drug reactions (ADRs) these agents using real-world data from the KOrean College Rheumatology BIOlogics & Targeted Therapy Registry (KOBIO).Methods: and ADR patients with rheumatoid arthritis (RA) ankylosing spondylitis (AS) were extracted KOBIO, relative risks ADRs calculated contingency tables. Significant drug–ADR pairs...
pISSN: 2093-940X, eISSN: 2233-4718 Copyright c 2015 by The Korean College of Rheumatology. All rights reserved. This is a Free Access article, which permits unrestricted non-commerical use, distribution, and reproduction in any medium, provided the original work properly cited. Clinical Image Journal Rheumatic Diseases Vol. 22, No. 5, October, http://dx.doi.org/10.4078/jrd.2015.22.5.332