A5021338398- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Obstructive Sleep Apnea Research
- Cancer-related Molecular Pathways
- Allergic Rhinitis and Sensitization
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Asthma and respiratory diseases
- RNA modifications and cancer
- Biochemical effects in animals
- GABA and Rice Research
- Cancer, Hypoxia, and Metabolism
- Nasal Surgery and Airway Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Tracheal and airway disorders
- Technology and Data Analysis
- Tryptophan and brain disorders
- Amino Acid Enzymes and Metabolism
- Meningioma and schwannoma management
- Head and Neck Cancer Studies
- Healthcare and Venom Research
- Biochemical Analysis and Sensing Techniques
- Olfactory and Sensory Function Studies
- Oral and Maxillofacial Pathology
- Alzheimer's disease research and treatments
Seoul National University Bundang Hospital
2017-2025
Seoul National University
2011-2025
Dong-Eui University
2014-2024
Seonam University
2024
CHA University
2022-2024
National University College
2021-2023
Korea Advanced Institute of Science and Technology
2023
New Generation University College
2021-2023
University of Ulsan
2004-2021
Ulsan College
2004-2021
Abstract Background Pyriform sinus fistula is a rare brachial pouch anomaly. However, it difficult and risky to remove the tract completely. Circumferential chemocauterization of internal opening with trichloroacetic acid (TCA) for pyriform simple, reproducible, reliable, causes less morbidity. The aim this study was determine feasibility TCA fistula. Methods This retrospective enrolled 44 patients who were diagnosed underwent chemocauterization. We retrospectively reviewed medical records...
<h3>Objective</h3>To evaluate the usefulness of septal batten grafts to correct cartilaginous deformities in endonasal septoplasty.<h3>Design</h3>Retrospective study.<h3>Setting</h3>University medical center.<h3>Patients</h3>Of 430 patients who underwent septoplasties from January 2006 2011, 30 received and were enrolled study. Twenty-eight male 2 female.<h3>Main Outcome Measures</h3>Thirty consecutive followed up for more than 6 months. Patterns deformity, materials used graft, surgical...
A predictive biomarker of immune checkpoint inhibitor (ICI)-based treatments in hepatocellular carcinoma (HCC) has not been clearly demonstrated. In this study, we focused on the infiltration and programmed death ligand 1 (PD-L1) expression tumor-associated macrophages (TAMs) tumor microenvironment HCC. Immunohistochemistry demonstrated that PD-L1 was preferentially expressed CD68+ HCC, suggestive its TAMs rather than T cells or (P < 0.05). co-culture experiment using activated M2...
Systemic inflammation plays a key role in the pathogenesis of obstructive sleep apnea (OSA); however, easy-to-use methods to evaluate severity systemic have yet be developed. This study investigated association between markers that could derived from complete blood count (CBC) profile and parameters large number patients with OSA.Patients who visited our hospital's Otorhinolaryngology Sleep Clinic January 2017 April 2022 underwent polysomnography routine laboratory tests, including CBC....
Background With the help of contemporary computer technology it is possible to create a virtual surgical environment (VSE) for training. This article describes patient‐specific rhinologic simulation platform that supports rehearsal endoscopic skull‐base surgery. We also share our early experience with select cases. Methods A VSE was developed, featuring highly efficient direct 3‐dimensional (3D) volume renderer simultaneous stereoscopic feedback during manipulation anatomy, as well...
Abstract Conventionally, apnea–hypopnea index (AHI) is used to define and categorize the severity of obstructive sleep apnea. However, routine polysomnography (PSG) includes multiple parameters for assessing The goal this study identify apnea phenotypes using unsupervised learning methods from PSG data. We identified four clusters 4,603 patients by 29 variable arranged according their mean AHI. Cluster 1, spontaneous arousal (mean AHI = 8.52/h); cluster 2, poor periodic limb movements...
The surgical procedure presented here involves an orbital exenteration through a transfacial approach, along with endoscopic access to the cavernous sinus and supraorbital fissure, in patient rhinocerebral mucormycosis. contents of sinus, including internal carotid artery (ICA), were resected, boundaries extending proximal dural ring superiorly petrous part ICA inferiorly. Necrotic tissue middle cranial fossa was identified removed.
Audio-visual speech recognition (AVSR) has become critical for enhancing in noisy environments by integrating both auditory and visual modalities. However, existing AVSR systems struggle to scale up without compromising computational efficiency. In this study, we introduce MoHAVE (Mixture of Hierarchical Audio-Visual Experts), a novel robust framework designed address these scalability constraints. By leveraging Mixture-of-Experts (MoE) architecture, activates modality-specific expert...
Despite the prevalence of sleep-related disorders, few studies have developed deep learning models to predict snoring using home-recorded smartphone audio. This study proposes a real-time detection method utilizing Vision Transformer-based model and recordings. Participants' sleep-breathing sounds were recorded smartphones, with concurrent Level I or II polysomnography (PSG) conducted in home hospital settings. A total 200 minutes audio per participant, corresponding 400 30-second sleep...
Cluster analyses on inflammatory markers of chronic rhinosinusitis (CRS) in Asians from multicenter data are lacking. This study aimed to identify the endotypes CRS Koreans and evaluate relationship between clinical parameters.Nasal tissues were obtained patients with controls who underwent surgery. The investigated by measuring interleukin (IL)-5, interferon (IFN)-γ, IL-17A, IL-22, IL-1β, IL-6, IL-8, matrix metalloproteinase-9, eotaxin-3, eosinophil cationic protein, myeloperoxidase (MPO),...
J Oral Pathol Med (2012) 41: 384–388 Background: Leukoplakia of the lateral tongue is frequently associated with risk malignancy. Although incisional biopsy accepted as a standard technique for evaluation, possibility underdiagnosis, and therefore missed diagnosis malignancy, remains at all times. The aim this study was to determine rate underdiagnosis by leukoplakia elucidate underlying cause underdiagnosis. Methods: Twenty-two patients in who had undergone excisional suspicion malignancy...
Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a multidimensional disease. In this study, we performed an unsupervised cluster analysis of CRSwNP using routinely available clinical markers. Methods We conducted retrospective review patients treated endoscopic sinus surgery due to medically intractable bilateral from 2009 2017. Unsupervised was patient's features, including age, peripheral blood eosinophil, tissue eosinophilia, Lund‐Mackay computed tomography (CT) scores,...
Breathing sounds during sleep are an important characteristic feature of obstructive apnea (OSA) and have been regarded as a potential biomarker. can be easily recorded using microphone, which is found in most smartphone devices. Therefore, it may easy to implement evaluation tool for prescreening purposes.To evaluate OSA prediction models smartphone-recorded identify optimal settings with regard noise processing sound selection.A cross-sectional study was performed among patients who...
FK506 binding protein 12 (FK506BP) belongs to a family of immunophilins, and is involved in multiple biological processes. However, the function FK506BP corneal disease remains unclear. In this study, we examined protective effects on dry eye Botulinum toxin A (BTX-A) induced mouse model, using cell-permeable PEP-1-FK506BP protein. efficiently transduced into human epithelial cells time- dose-dependent manner, remained stable for 48 h. addition, demonstrated that topical application was...
A narrow bony cochlear nerve canal (BCNC) is associated with sensorineural hearing loss necessitating implantation (CI). This study evaluated the implications of BCNC width for post-CI outcomes. total 56 children who had received CIs were included. The patients divided into three groups according to (Group 1: diameter < 1.4 mm, n = 17; Group 2: 1.4-2.0 14; 3: > 2.0 25). speech performances compared among width. correlation between and performance was evaluated. Logistic regression analysis...
Abstract Methylmercury (MeHg), an environmental pollutant, is a ubiquitous neurotoxicant that ultimately leads to neurodegenerative diseases. New experimental models are needed for public health toxicity testing associated with this pollutant. In study, human pluripotent stem cell‐based brain‐on‐a‐chip, named Communicative Astrocyte–Neuron DYnamics chip (CANDY chip), reported, which enables observation of the interactions neurons astrocytes and accurate assessment responses penetration MeHg...
The mechanism and predictive biomarkers of sinonasal inverted papilloma (IP) transformation into squamous cell carcinoma (SCC) are still unclear. We investigated the genetic mutations involved biomarkers. Fourteen patients with SCC arising from IP six IPs without malignant (sIP) were included. DNA was extracted separately areas normal tissue, IP, dysplasia, SCC. Whole exome sequencing immunohistochemistry performed. Major oncogenic observed in progression to most frequently mutated genes...
The inhibition of nitric oxide (NO) and cyclooxygenase-2 (COX-2) production is considered to be a promising approach the treatment various diseases, including inflammation cancer. In this study, we examined effects Agrocybe chaxingu beta-glucan (polysaccharide) on lipopolysaccaride (LPS)-induced expression in murine macrophage Raw 264.7 cells as well 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema mice. polysaccharide significantly inhibited (P 0.01) LPS-induced iNOS COX-2...
Objectives Acinic cell carcinoma (AciCC) is a rarely encountered malignancy in parotid gland. Because AciCC rare and was recently recognized as the entity of malignancy, has been difficult to study. We aimed analyze diagnosis treatment experience for this our hospital. Methods retrospectively reviewed medical records 20 patients with gland diagnosed from 1990 2009. The preoperative computed tomography scan, fine needle aspiration cytology (FNAC) intraoperative frozen section results were...