A5027435828- Hearing, Cochlea, Tinnitus, Genetics
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Optical Coherence Tomography Applications
- Photoacoustic and Ultrasonic Imaging
- Noise Effects and Management
- Congenital Ear and Nasal Anomalies
- Ear and Head Tumors
- Speech and Audio Processing
- Facial Nerve Paralysis Treatment and Research
- Tactile and Sensory Interactions
- Tracheal and airway disorders
- Glaucoma and retinal disorders
- Advanced Sensor and Energy Harvesting Materials
- Antimicrobial Peptides and Activities
- Hearing Impairment and Communication
- Cerebral Venous Sinus Thrombosis
- Head and Neck Anomalies
- Cancer-related molecular mechanisms research
- Innovative Energy Harvesting Technologies
- Sinusitis and nasal conditions
- Connexins and lens biology
- Nasal Surgery and Airway Studies
- Mesoporous Materials and Catalysis
Ajou University
2016-2025
Ajou University Hospital
2016-2023
Kyungpook National University
2012-2019
Kyungpook National University Hospital
2013-2016
National University College
2012-2014
New Generation University College
2012-2014
Seoul National University Hospital
2008-2013
Seoul National University
2009-2012
Seoul National University Bundang Hospital
2010-2011
Seoul Metropolitan Government
2009
We proposed a piezoelectric artificial basilar membrane (ABM) composed of microelectromechanical system cantilever array. The ABM mimics the tonotopy cochlea: frequency selectivity and mechanoelectric transduction. fabricated exhibits clear in an audible range (2.92-12.6 kHz). Also, animal model was used to verify characteristics as front end for potential cochlear implant applications. For this, signal processor convert output from electrical stimulus auditory neurons. neurons delivered...
A triboelectric-based artificial basilar membrane (TEABM) can mimic cochlear tonotopy by triboelectrification between Kapton film and aluminum foil. The two films are stacked clamped to form a beam structure. TEABM is tested using an animal model verify the feasibility of self-powered acoustic sensor for prototype implant. As service our authors readers, this journal provides supporting information supplied authors. Such materials peer reviewed may be re-organized online delivery, but not...
We aimed to estimate the effects of various risk factors on hearing level in Korean adults, using data from Korea National Health and Nutrition Examination Survey. examined 13,369 participants collected between 2009 2011. Average thresholds at low (0.5, 1, 2 kHz) high frequencies (3, 4, 6 kHz), were investigated accordance with known via multiple regression analysis featuring complex sampling. additionally evaluated 4,810 who completed a questionnaire concerned different types noise...
We developed an augmented-reality system that combines optical coherence tomography (OCT) with a surgical microscope.By sharing the common path in microscope and OCT, we could simultaneously acquire OCT views.The was tested to identify middle-ear inner-ear microstructures of mouse.Considering probability clinical application including otorhinolaryngology, diseases such as effusion were visualized using vivo mouse images acquired through eyepiece during manipulation proposed system.This is...
Abstract Chronic tympanic membrane (TM) perforations can cause otorrhea. To date, various types of tissue engineering techniques have been applied for the regeneration chronic TM perforations. However, application nanofibers with radially aligned nanostructures and simultaneous release growth factors never in Here, epidermal factor (EGF)–releasing nanofibrous patches (ERA‐NFPs) are developed perforated TMs. First, radial alignments presence EGF ERA‐NFPs analyzed. is confirmed to be released...
We report the application of optical coherence tomography (OCT) to diagnosis and evaluation otitis media (OM). Whereas conventional diagnostic modalities for OM, including standard pneumatic otoscopy, are limited visualizing surface tympanic membrane (TM), OCT effectively reveals depth-resolved microstructure below TM with very high spatial resolution, potential advantage its use diagnosing different types OM. examined 840-nm spectral domain-OCT (SD-OCT) clinically, using normal ears...
Cisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes remains unclear. purpose of this study was identify the involvement receptor-interacting protein kinase (RIP)3-dependent necroptosis in cisplatin-induced vitro and vivo. Sprague–Dawley rats (SD, 8 week) were treated via intraperitoneal (i.p.) injection with (16 mg/kg for 1 day), their thresholds measured auditory brainstem response (ABR) method. Hematoxylin eosin (H & E) staining,...
Abstract Although neurovascular compression of the cochlear nerve (NVC-C) presenting as typewriter tinnitus is a discrete disease category, verified diagnostic criteria are lacking. We sought to refine for NVC-C by reference relatively large case series. The medical records 22 patients were retrospectively reviewed. Psychoacoustic characteristics, results work-up (including audiovestibular neurophysiological tests and radiological evaluations), initial treatment response carbamazepine...
The study presented in this paper assessed the frequency selectivity of an artificial basilar membrane (ABM) constructed using a piezoelectric beam array with narrow supports. Three ABM samples were constructed. Each contained 16 beams various lengths one-dimensional array. To experimentally assess ABM, mechanical vibration induced either by electrical or acoustic stimulus was measured scanning laser-Doppler vibrometer. electro-mechanical and acousto-mechanical transfer functions defined for...
The aim of this study was to analyze the effectiveness decalcification using ethylenediaminetetraacetic acid (EDTA) as an optical clearing method enhance depth visibility internal soft tissues cochlea. Ex vivo mouse and guinea pig cochlea samples were soaked in EDTA solutions for decalcification, swept source coherence tomography (OCT) used imaging modality monitor decalcified consecutively. monitored noninvasive cross-sectional images showed that had be subsequent 7 14 days, respectively,...
Objective: To describe the results of a thorough evaluation in large series patients with an enlarged vestibular aqueduct (EVA), focusing on manifestations etiological considerations. Study Design: Retrospective chart review EVA. Setting: Tertiary referral center. Patients: A total 22 EVA median age 8 years (6 mo–35 yr) who underwent both audiovestibular and radiologic examinations. Main Outcome Measures: Patient demographics, findings, audiologic results, symptoms, findings neurotologic...
The aim of this study was to investigate the efficacy preoperative and intraoperative steroid administration for inner ear protection in cochlear implantation (CI). Nineteen subjects who underwent CI were included study, 10 enrolled as controls (steroid-administered group, n = 19; control 10). Dexamethasone (dexamethasone sodium phosphate, 5 mg/ml) systemically administered preoperatively (1 ml) topically applied during (0.5 ml). extent hearing preservation (HP) after change bithermal...
Abstract In cochlear implants, the electrode insertion trauma during surgery can cause damage residual hearing. Preserving hearing is an important challenge and localized administration of drugs, such as steroids, one most promising ways, but remains a challenge. Here, microscaffold array (MiSCEA) consisting microfabricated flexible 3D for steroid reservoir reported. The MiSCEA without loaded drug tested by measuring electrically evoked auditory brainstem response cochlea in guinea pigs ( n...
In patients with cochleovestibular malformations, surgeons should always consider the possibility of an aberrant course or shape facial nerve (FN). our series, majority cases could be successfully implanted without major complications through careful handling FN and ossicles.To assess frequency, type, surgical implications aberrations encountered during cochlear implantation (CI).Medical records radiologic findings 972 who underwent CI from 1988 to 2009 were reviewed retrospectively....
Objectives/Hypothesis The aim of this study was to compare the hearing results patients with idiopathic sudden sensorineural loss (ISSNHL) who initially were treated either a combination therapy systemic steroids (SS) and intratympanic steroid injection (IT‐S) or SS only. Methods followed retrospective case‐control design. One‐hundred five diagnosed ISSNHL required treatment via admission enrolled in study. control group (n = 53) SS, 52) received as well IT‐S. We divided according...
Significant technical and optical advances are required for intraoperative coherence tomography (OCT) to be utilized during otological surgeries. Integrating OCT with surgical microscopy makes it possible evaluate soft tissue in real-time at a high resolution. Herein, we describe an augmented-reality, OCT/microscope system extended working distance of 280 mm, providing more space manipulation than conventional techniques. We initially performed ex vivo experiments performance. In addition,...
The recent increase in the reported incidence of congenital cholesteatoma (CC) may be secondary to widespread use otoendoscopy as well an increased awareness these lesions among primary care physicians. However, little research about CC has been conducted a large group patients. This study aimed analyze clinical characteristics including annual number patients, symptoms, age at diagnosis, stage and type disease, surgical techniques, recurrence, postoperative complications.Retrospective chart...
While auditory neuropathy spectrum disorder (ANSD) is a heterogeneous and its management quite varies depending upon the etiology, even including self-resolution, OTOF an important molecular etiology of prelingual ANSD has emerged as attractive target for implementation precision medicine in terms timing prognosis prediction rehabilitation. However, to date, literature lacking genotype–phenotype relationship this gene well efficient testing strategy clinic many populations make things more...
This study evaluated the effects of sarpogrelate, a selective 5-hydroxytryptamine (5-HT) 2A receptor antagonist, on residual hearing preservation and inflammatory responses after cochlear implantation (CI) in an animal model. The damaging CI were simulated male albino guinea pigs by using dummy electrode. Animals divided into three groups: control (n=12, electrode insertion only), SPG-1004 (n=7, low-capacity pump with sarpogrelate), SPG-2004 (n=6, high-capacity sarpogrelate). Sarpogrelate...
Background: Endoscopic technique is often applied for the diagnosis of diseases affecting internal organs and image-guidance surgical procedures. Although endoscope has become an indispensable tool in clinic, its utility been limited to medical offices or operating rooms because large size ancillary devices. In addition, basic design imaging capability system have remained relatively unchanged decades.
To evaluate the factors that limit post-cochlear implantation (CI) speech perception in prelingually deaf children.Patients with CI were divided into two groups according to Category of Auditory Performance (CAP) scores 3 years post-CI: poor performance group (poor group, CAP scores≤4, n=41) and good (good scores≥5, n=85). The distribution contribution potential limiting related post-CI was compared.Perinatal problems, inner ear anomalies, narrow bony cochlear nerve canal (BCNC),...
Objective Steroids have been widely used to treat inner‐ear diseases such as sudden sensorineural hearing loss, tinnitus, and Meniere's disease. They can be given via either systemic or intratympanic (IT) injection. The purpose of the present study was explore differences in intracochlear steroid distribution by administration method employed (systemic vs. IT injection). Study Design Animal study. Methods Twenty‐three Sprague‐Dawley rats were fluorescein isothiocyanate‐labeled dexamethasone...