A5101673706- Hearing, Cochlea, Tinnitus, Genetics
- Vestibular and auditory disorders
- Antioxidant Activity and Oxidative Stress
- Ubiquitin and proteasome pathways
- Ear Surgery and Otitis Media
- Retinoids in leukemia and cellular processes
- Heat shock proteins research
- Bioactive natural compounds
- Cancer-related Molecular Pathways
- ATP Synthase and ATPases Research
- Antimicrobial Peptides and Activities
- Mitochondrial Function and Pathology
- RNA Interference and Gene Delivery
- Connexins and lens biology
- Tracheal and airway disorders
- Cancer, Hypoxia, and Metabolism
- DNA Repair Mechanisms
- Ion Channels and Receptors
- Cell death mechanisms and regulation
- Reconstructive Surgery and Microvascular Techniques
- Olfactory and Sensory Function Studies
- Calcium signaling and nucleotide metabolism
- Telomeres, Telomerase, and Senescence
- Neuroinflammation and Neurodegeneration Mechanisms
- Animal Nutrition and Physiology
Ajou University
2010-2023
Cisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes remains unclear. purpose of this study was identify the involvement receptor-interacting protein kinase (RIP)3-dependent necroptosis in cisplatin-induced vitro and vivo. Sprague–Dawley rats (SD, 8 week) were treated via intraperitoneal (i.p.) injection with (16 mg/kg for 1 day), their thresholds measured auditory brainstem response (ABR) method. Hematoxylin eosin (H & E) staining,...
Endoplasmic reticulum (ER) stress is a common factor during the aging process. Heat shock 1 (HSF1) plays critical role in ER stress; however, its exact function age-related hearing loss (ARHL) has not been fully elucidated. The purpose of present study was to identify HSF1 ARHL. In this study, we demonstrated that inner and outer hair cells their supporting predominant high-frequency region (basal turn, 32 kHz) ARHL cochleae. cochlea, levels marker proteins p-eIF2α CHOP increased as protein...
The relationship between type 1 diabetes and hearing loss is not well known, although based on many pathological studies, 2 induced associated with microcirculation problems in the inner ear. purpose of this study was to investigate correlation through function immunohistochemical analyses using diabetic Akita or wild-type (WT) mice. mice had a significant increase thresholds, blood glucose, insulin tolerance compared WT Histological analysis showed that cells damage mitochondria spiral...
Hearing loss in the elderly cause communication difficulties, decreased quality of life, isolation, loneliness and frustration. The aim our study was to investigate effect drug repurposing candidates aging mouse. selected candidate drugs for age-related hearing (ARHL) included atorvastatin (AS) sarpogrelate. Monotherapy or fixed dose combination (FDC) products were administered via oral gavage 6 consecutive months. Auditory outcomes showed significant preservation AS-treated mice compared...
Cholesterol is a risk factor for age-related hearing loss (ARHL). However, the effect of cholesterol on organ Corti during onset ARHL unclear. We established mouse model group (24 months, n = 12) and young (6 12). Auditory thresholds were measured in both groups using auditory brainstem response (ABR) at frequencies 8, 16, 32 kHz. Subsequently, mice sacrificed subjected to histological analyses, including transmission electron microscopy (TEM), H&E, Sudan Black B (SBB), Filipin staining,...
Stress could be a contributing cause of sudden hearing loss. This study intended to develop an animal model stress-induced loss and evaluate the effects dexamethasone.Two stress models (I II) for rats were designed using various stressors modified by adjusting protocol increase threshold significantly. For with significant in after exposure, changes cortisol levels according exposure measured. The shift change cellular structure associated dexamethasone administration analyzed.While...
Mitochondrial dysfunction is linked to age-related senescence phenotypes. We report here the pathway increasing nucleoid remodeling and biogenesis in mitochondria during of foreskin human diploid fibroblasts (fs-HDF) WI-38 cells. Replicative fs-HDF cells increased mitochondrial as indicated by 5-bromo-2'-deoxyuridine (BrdU) incorporation transcription factor A (TFAM) expression enlarged fused mitochondria. was accompanied old cells, levels OXPHOS complex-I, -IV -V subunits, PGC-1α NRF1 were...
The mechanism by which 12-O-tetradecanoylphorbol-13-acetate (TPA) bypasses cellular senescence was investigated using human diploid fibroblast (HDF) cell replicative as a model. Upon TPA treatment, protein kinase C (PKC) α and PKCβ1 exerted differential effects on the nuclear translocation of cytoplasmic pErk1/2, maintains senescence. PKCα accompanied pErk1/2 to nucleus after freeing it from PEA-15pS(104) via then rapidly ubiquitinated degraded within nucleus. Mitogen-activated docking motif...
Mastoidectomy is a surgical procedure for the treatment of chronic otitis media. This study investigated ability rat stromal vascular fraction cells (rSVF) in combination with polycaprolactone (PCL) scaffolds and osteogenic differentiation-enhancing blood products to promote regeneration mastoid bone defect. Twenty male Sprague Dawley rats were randomly divided according obliteration materials: (1) control, (2) PCL scaffold only, (3) rSVFs + PCL, (4) platelet-rich plasma, (5) whole plasma...
Abstract Cellular senescence plays a key role in complicated biological processes, including development, aging, and tumorigenesis. Hallmarks of cellular are metabolically active but not responsive to mitogens, therefore, decreased cell growth, cycle arrest, reached the flat large shapes. We have recently reported that high expression senescence-associated p-extracellular signal-regulated protein kinase 1/2 (SA-pErk1/2) can induce p21WAF1 via activation transcription factor, SP1. In present...