A5014852688- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Vestibular and auditory disorders
- Hearing Loss and Rehabilitation
- Conducting polymers and applications
- Acoustic Wave Phenomena Research
- Calcium signaling and nucleotide metabolism
Ajou University
2022-2025
This study evaluated the effects of sarpogrelate, a selective 5-hydroxytryptamine (5-HT) 2A receptor antagonist, on residual hearing preservation and inflammatory responses after cochlear implantation (CI) in an animal model. The damaging CI were simulated male albino guinea pigs by using dummy electrode. Animals divided into three groups: control (n=12, electrode insertion only), SPG-1004 (n=7, low-capacity pump with sarpogrelate), SPG-2004 (n=6, high-capacity sarpogrelate). Sarpogrelate...
Cholesterol is a risk factor for age-related hearing loss (ARHL). However, the effect of cholesterol on organ Corti during onset ARHL unclear. We established mouse model group (24 months, n = 12) and young (6 12). Auditory thresholds were measured in both groups using auditory brainstem response (ABR) at frequencies 8, 16, 32 kHz. Subsequently, mice sacrificed subjected to histological analyses, including transmission electron microscopy (TEM), H&E, Sudan Black B (SBB), Filipin staining,...
In mammals, hearing loss is irreversible due to the lack of regenerative capacity auditory epithelium. However, stem/progenitor cells in mammalian cochleae may be a therapeutic target for regeneration. The ubiquitin proteasome system plays an important role cochlear development and maintenance. this study, we investigated C-terminal hydrolase L1 (UCHL1) process transdifferentiation supporting (SCs) into hair (HCs). expression UCHL1 gradually decreased as HCs developed was restricted inner...
Presbycusis, also referred to as age-related hearing loss (ARHL), is a multifaceted condition caused by the natural aging process affecting auditory system. Genome-wide association studies (GWAS) in human populations can identify potential genes linked ARHL. Despite this, our knowledge of biochemical and molecular mechanisms behind remains incomplete. This study aims evaluate protective tool for ARHL treatment comparing blood-based target gene-miRNA associations regulated To promising ARHL,...
The inner ear is responsible for both hearing and balance in the body, since initial development of otic (inner ear) organoids from mouse pluripotent stem cells (PSCs) 2013, significant advances have been made this field. Bone morphogenetic proteins, fibroblast growth factors, Wnt agonists, which are signaling molecules early ear, can induce PSCs into fate. In hair surrounding supporting essential proper function structure. Recent advancements organoid research enabled generation that...
Abstract In mammals, hearing loss is irreversible due to the lack of regenerative capacity auditory epithelium. However, recently identified resident stem/progenitor cell population in mammalian cochleae a therapeutic targets for regeneration. The ubiquitin proteasome system plays an important role cochlear development and maintenance. deubiquitinating enzymes hair (HC) regeneration, through transdifferentiation neighboring supporting cells (SCs) into HCs cochlea, remains unknown. this...