A5027127816- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Ear Surgery and Otitis Media
- Surgical Simulation and Training
- Noise Effects and Management
- Simulation-Based Education in Healthcare
- Augmented Reality Applications
- Bacterial Infections and Vaccines
- Meningioma and schwannoma management
- Speech and Audio Processing
- Neuroscience and Neural Engineering
- Nerve injury and regeneration
- Neural dynamics and brain function
- Anatomy and Medical Technology
- Radiology practices and education
- Hearing Impairment and Communication
- Human Motion and Animation
- Head and Neck Surgical Oncology
- Conducting polymers and applications
- Ultrasonics and Acoustic Wave Propagation
- Time Series Analysis and Forecasting
- Pneumonia and Respiratory Infections
- Acoustic Wave Phenomena Research
- Nasal Surgery and Airway Studies
The Royal Victorian Eye & Ear Hospital
2016-2025
The University of Melbourne
2016-2025
Cochlear (Australia)
2006-2024
University Hospital Galway
2023
Royal Victoria Eye and Ear Hospital
2017-2021
Laryngograph (United Kingdom)
2013-2017
University of British Columbia
2017
Rensselaer Polytechnic Institute
2017
University of Aberdeen
2014-2016
Loughborough University
2016
<b><i>Objective:</i></b> To update a 15-year-old study of 800 postlinguistically deaf adult patients showing how duration severe to profound hearing loss, age at cochlear implantation (CI), onset etiology and CI experience affected outcome. <b><i>Study Design:</i></b> Retrospective multicenter study. <b><i>Methods:</i></b> Data from 2251 implanted since 2003 in 15 international centers were collected speech scores quiet...
Objective To test the influence of multiple factors on cochlear implant (CI) speech performance in quiet and noise for postlinguistically deaf adults, to design a model predicted auditory with CI as function significant factors. Study Design Retrospective multi-centre study. Methods Data from 2251 patients implanted since 2003 15 international centres were collected. Speech scores converted into percentile ranks remove differences between centres. The pre-, per- postoperative factors, such...
The rapid expansion of 16S rRNA gene sequencing in challenging clinical contexts has resulted a growing body literature variable quality. To large extent, this is due to failure address spurious signal that characteristic samples with low levels bacteria and high non-bacterial DNA. We have developed workflow based on the paired-end read Illumina MiSeq-based approach, which enables significant improvement data quality, post-sequencing. demonstrate efficacy methodology through its application...
Degeneration of auditory neurons occurs after deafening and is associated with damage to the organ Corti. The administration neurotrophins can protect against degeneration if given shortly deafening. However, it not known whether delayed neurotrophins, when significant has already occurred, will provide similar protection. Furthermore, little about effects on peripheral processes or these resprout. This study examined morphological following brain-derived neurotrophic factor neurotrophin-3....
This study reviews the cochlear histology from four hearing preservation implantation experiments conducted on 73 guinea pigs our institution, and relates histopathological findings to residual hearing. All had normal prior surgery underwent via a cochleostomy with silastic-platinum dummy electrode. Pure tone auditory brainstem response (ABR) thresholds 2 32 kHz were recorded surgery, at one weeks postoperatively. The cochleae then fixed in paraformaldehyde, decalcified, paraffin embedded,...
To monitor cochlear function during implantation and determine correlations with postoperative acoustic hearing.Cochlear response telemetry measures directly from implant electrodes. We have adapted this system to provide real-time (RT-CRT) monitoring of a patient's hearing as the electrode array is inserted.Eighteen subjects (1 child 17 adults) sloping high frequency loss were implanted Cochlear Ltd slim straight arrays (CI422/CI522). Tone bursts (500 Hz, 100-110 dB) presented at 14 Hz...
We proposed a piezoelectric artificial basilar membrane (ABM) composed of microelectromechanical system cantilever array. The ABM mimics the tonotopy cochlea: frequency selectivity and mechanoelectric transduction. fabricated exhibits clear in an audible range (2.92-12.6 kHz). Also, animal model was used to verify characteristics as front end for potential cochlear implant applications. For this, signal processor convert output from electrical stimulus auditory neurons. neurons delivered...
Aim To record cochlear responses to acoustic stimulation (electrocochleography) directly from a implant (CI) in awake recipients with residual hearing, using an adaptation of Neural Response Telemetry (NRT) that achieves 10-ms recording window. Background Modern implants contain circuitry for neural electrical stimulation, which is known Cochlear Ltd systems as NRT. We adapted NRT achieve extended window long enough electrocochleogram. This paper reports recordings made this system hearing....
To study electric acoustic stimulation, we have developed a model of guinea pig cochlear implantation via cochleostomy. Thirty minutes prior to implantation, hyaluronic acid/carboxymethylcellulose bead, loaded with either dexamethasone or normal saline, was placed upon the round window membrane. Animals that did not receive beads acted as controls. Pure-tone auditory brainstem response thresholds were estimated before and after electrode insertion, 1 4 weeks later. Selected histology...
To document incidences of vestibular dysfunction after cochlear implantation and investigate why it occurs. This work was also motivated by a desire to provide the basis for better preoperative counseling postoperative therapy implant patients.Melbourne Cochlear Implant Clinic at tertiary referral hospital.Prospective observational study.One hundred forty-six adult recipients, mean age, 60 years (range, 20-90 yr).Postoperative disturbance defined as symptoms lasting 1 week or longer surgery....
A cochlear implant may be used to electrically stimulate spiral ganglion neurons (SGNs) in people with severe sensorineural hearing loss (SNHL). However, these progressively degenerate after SNHL due of neurotrophins normally supplied by sensory hair cells (HCs). Experimentally, exogenous neurotrophin administration prevents SGN degeneration but can also result abnormal resprouting their peripheral fibers. This study aimed create a target-derived source increase neuron survival and redirect...
Release of neurotrophin-3 (NT3) and brain-derived neurotrophic factor (BDNF) from hair cells in the cochlea is essential for survival spiral ganglion neurons (SGNs). Loss associated with a sensorineural hearing loss therefore results degeneration SGNs, potentially reducing performance cochlear implant. Exogenous replacement either or both neurotrophins protects SGNs after deafness. We previously incorporated NT3 into conducting polymer polypyrrole (Ppy) synthesized para-toluene sulfonate...
Abstract Objectives/Hypothesis: This study aims to determine whether there are improved performances in cadaver temporal bone dissection after training using a VR simulator as teaching aid compared with traditional methods Study design: Randomized control trial. Methods: Twenty participants minimal experience were recruited for this randomized After receiving the same didactic they into two groups. The group receive addition via such small tutorials, videos, and models. received supervised...
Applying neurotrophins to the round window immediately after a single noise exposure will prevent noise-induced hidden hearing loss.Loud can eliminate neural connections between inner hair cells and their afferent neurons (thereby diminishing sound perception) without causing detectable change on audiogram. This phenomenon is termed loss.Guinea pigs were exposed for 2 hours 4 8 kHz at either 95 or 105 dB SPL. Immediately afterward μl bolus of (brain-derived neurotrophic factor 1 μg/μl,...
In Brief Objectives: To compare speech perception outcomes between bilateral implantation (cochlear implants [CIs]) and bimodal rehabilitation (one CI on one side plus hearing aid [HA] the other side) to explore clinical factors that may cause asymmetric performances in intelligibility two ears case of implantation. Design: Retrospective data from 2247 patients implanted since 2003 15 international centers were collected. Intelligibility scores, measured quiet noise, converted into...
Abstract Image registration is a fundamental task in image analysis which the transform that moves coordinate system of one to another calculated. Registration multi-modal medical images has important implications for clinical diagnosis, treatment planning, and image-guided surgery as it provides means bringing together complimentary information obtained from different modalities. However, since modalities have properties due their acquisition methods, remains challenging find fast accurate...
Multi-modal three-dimensional (3-D) image segmentation is used in many medical applications, such as disease diagnosis, treatment planning, and image-guided surgery. Although multi-modal images provide information that no single modality alone can provide, integrating to be a challenging task. Numerous methods have been introduced solve the problem of recent years. In this paper, we propose solution for task brain tumor segmentation. To end, first introduce method enhancing an existing...