A5048931757- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Meningioma and schwannoma management
- Ear Surgery and Otitis Media
- Neurofibromatosis and Schwannoma Cases
- Noise Effects and Management
- Facial Nerve Paralysis Treatment and Research
- Vestibular and auditory disorders
- Ear and Head Tumors
- Hearing Impairment and Communication
- Speech and Audio Processing
- Vascular Malformations Diagnosis and Treatment
- Tribology and Lubrication Engineering
- Neuroscience and Neural Engineering
- Acoustic Wave Resonator Technologies
- Head and Neck Surgical Oncology
- Head and Neck Anomalies
- Adhesion, Friction, and Surface Interactions
- Ophthalmology and Eye Disorders
- RNA and protein synthesis mechanisms
- Trigeminal Neuralgia and Treatments
- Bat Biology and Ecology Studies
- Congenital Ear and Nasal Anomalies
- Salivary Gland Tumors Diagnosis and Treatment
- Acoustic Wave Phenomena Research
Centre Hospitalier Universitaire de Lille
2016-2025
Université de Lille
2016-2025
Assistance Publique – Hôpitaux de Paris
2025
Hôpital Saint-Louis
2025
Inserm
2015-2024
Hôpital Roger Salengro
2014-2024
Biomatériaux et Bioingénierie
2018-2023
Systèmes avancés de délivrance de principes actifs
2018-2023
Centre Hospitalier Universitaire de Tours
2020
Association Française de Pédiatrie Ambulatoire
2020
<b><i>Objective:</i></b> To update a 15-year-old study of 800 postlinguistically deaf adult patients showing how duration severe to profound hearing loss, age at cochlear implantation (CI), onset etiology and CI experience affected outcome. <b><i>Study Design:</i></b> Retrospective multicenter study. <b><i>Methods:</i></b> Data from 2251 implanted since 2003 in 15 international centers were collected speech scores quiet...
Objective To test the influence of multiple factors on cochlear implant (CI) speech performance in quiet and noise for postlinguistically deaf adults, to design a model predicted auditory with CI as function significant factors. Study Design Retrospective multi-centre study. Methods Data from 2251 patients implanted since 2003 15 international centres were collected. Speech scores converted into percentile ranks remove differences between centres. The pre-, per- postoperative factors, such...
To prospectively evaluate a fast spin-echo (SE) diffusion-weighted sequence for magnetic resonance (MR) imaging of recurrent cholesteatoma in patients who have undergone middle ear surgery.The study was approved by the institutional review board, and informed consent obtained from all patients. Twenty-four (10 female 14 male patients; mean age, 44 years) had resection were referred MR imaging. performed with 1.5-T unit using unenhanced SE at b factors 0 800 sec/mm(2), T2-weighted imaging,...
<b><i>Introduction:</i></b> Cochlear implantation is a recent approach proposed to treat single-sided deafness (SSD) and asymmetric hearing loss (AHL). Several cohort studies showed its effectiveness on tinnitus variable results binaural hearing. The main objective of this study assess the outcomes cochlear other treatment options in SSD/AHL quality life. <b><i>Methods:</i></b> This prospective multicenter was conducted 7 tertiary university...
Usher syndrome (USH) combines sensorineural deafness with blindness. It is inherited in an autosomal recessive mode. Early diagnosis critical for adapted educational and patient management choices, genetic counseling. To date, nine causative genes have been identified the three clinical subtypes (USH1, USH2 USH3). Current diagnostic strategies make use of a genotyping microarray that based on previously reported mutations. The purpose this study was to design more accurate molecular tool.We...
In Brief Objectives: To assess audiological performance, satisfaction rate, and side effects of 100 patients who have been using the middle ear implant Vibrant Soundbridge (VSB) for 5 to 8 yr when compared with data collected from 3 18 mo postsurgery. Design: Audiological testing subjective evaluation self-assessment scales were performed in 77 out VSB years. The results months (audiological testing) (self-assessment scales) after surgery. Twenty-three not evaluated different reported...
Objective: Recommendation for cochlear implant (CI) treatment individuals with severe to profound single-sided deafness (SSD) and asymmetrical hearing loss (AHL) is on the rise. This raises need greater consistency in definition of CI candidacy these cases assessment methods patient-related benefits permit effective comparison interpretation outcomes both conventional implantable options across studies. Method: During a dedicated seminar AHL patients, panellists closing round table reviewed...
In Brief Objectives: To compare speech perception outcomes between bilateral implantation (cochlear implants [CIs]) and bimodal rehabilitation (one CI on one side plus hearing aid [HA] the other side) to explore clinical factors that may cause asymmetric performances in intelligibility two ears case of implantation. Design: Retrospective data from 2247 patients implanted since 2003 15 international centers were collected. Intelligibility scores, measured quiet noise, converted into...
Usher syndrome (USH) is a clinically and genetically heterogeneous disorder characterized by congenital hearing loss combined with retinitis pigmentosa. This dual sensorineural deficiency transmitted in an autosomal recessive mode. type I (USH1) the most severe form. Four loci responsible for USH1 (USH1A, 1B, 1C 1D) have previously been mapped, among which only USH1B gene has cloned. Using homozygosity mapping consanguineous family from Morocco, we identified novel locus USH1, USH1E, to...
Journal Article A proposed new contiguous gene syndrome on 8q consists of Branchio-Oto-Renal (BOR) syndrome, Duane a dominant form hydrocephalus and trapeze aplasia; implications for the mapping BOR Get access Christophe Vincent, Vincent Unité de Génétique Moléculaire Humaine (CNRS URA 1445), Institut Pasteur25 rue du Dr Roux, 75724 Paris Cédex 15 Search other works by this author on: Oxford Academic PubMed Google Scholar Vasiliki Kalatzis, Kalatzis Sylvie Compain, Compain Jacqueline...
Objective The Vibrant Soundbridge (VBS; Symphonix Devices, Inc., San Jose, CA, U.S.A.) is an active, semi-implantable, middle ear hearing device that directly drives the ossicular chain and used in treatment of patients with mild to severe sensorineural loss. benefits VBS effects surgery were examined compared preoperative aided condition 25 implants. Study Design Single-subject repeated-measures evaluations performed each patient acting as his or her own control. audiologic measures...
To describe the presentation of intralabyrinthine schwannomas (ILSs).Retrospective multicenter study involving 12 European skull base surgery tertiary referral centers.One hundred ten patients with diagnosis ILS, either labyrinth confined or extending into internal auditory meatus for less than 50% their volume.Data collected were age, sex, nature and timing presenting symptoms, hearing (according to AAO-HNS grading system), results vestibular tests (caloric cervical vestibular-evoked...
ObjectiveThe aim of this study was to compare a cochlear implant electrode array loaded with dexamethasone (DXM) conventional passive for the preservation residual hearing in gerbils.MethodsThirty Mongolian gerbils (Meriones unguiculatus) were implanted an eluting DXM (1 and 10%) on one side other side. Hearing thresholds determined by tone bursts auditory brainstem responses at 4–6 weeks post-implantation 1-year older gerbils.ResultsAfter post-implantation, statistically more preserved...
Significance Presbycusis, or age-related hearing loss, is a major public health issue and the principal potentially modifiable risk factor for dementia. It caused by environmental factors largely uncharacterized genetic factors. We compared DNA sequences across genomic coding regions between familial sporadic cases of severe presbycusis controls with normal hearing. The frequency ultrarare predicted pathogenic variants in genes known to cause dominant early-onset forms deafness was...
The recessive mode of transmission accounts for ∼75% inherited non syndromic deafness cases. We have previously designed the conditions linkage studies this highly heterogeneous disorder [Guilford et al. (1994) Nature Genet. 6, 24–28]. Here, using a similar approach, we studied segregation gene responsible congenital, profound and fully penetrant sensorineural in consanguineous family living an isolated region Lebanon. A maximum lod score 8.03 (θ=0.00) was detected with new polymorphic...