A5077738900- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Noise Effects and Management
- Ear Surgery and Otitis Media
- Cancer Treatment and Pharmacology
- Pain Mechanisms and Treatments
- Multiple Myeloma Research and Treatments
- Neuroscience and Music Perception
- Traumatic Brain Injury and Neurovascular Disturbances
- Ophthalmology and Eye Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Musculoskeletal pain and rehabilitation
- RNA regulation and disease
- Neuroscience of respiration and sleep
- Facial Nerve Paralysis Treatment and Research
- Pain Management and Placebo Effect
- Optical Imaging and Spectroscopy Techniques
- Chemotherapy-related skin toxicity
- Synthesis and pharmacology of benzodiazepine derivatives
- Peripheral Neuropathies and Disorders
- Respiratory Support and Mechanisms
- Axon Guidance and Neuronal Signaling
- Non-Invasive Vital Sign Monitoring
- Health, Medicine and Society
Inserm
2014-2025
Université Clermont Auvergne
2014-2025
Centre Hospitalier Universitaire de Clermont-Ferrand
2016-2024
Neuro-Dol
2015-2022
Centre Jean Perrin
2014-2015
Universitätsklinikum Tübingen
2012
Addenbrooke's Hospital
2012
University of Cambridge
2012
Laboratoire de Météorologie Physique
2011
Aix-Marseille Université
2001-2002
In Bilateria, many axons cross the midline of central nervous system, forming well-defined commissures. Whereas in mammals functions commissures forebrain and visual system are well established, at other axial levels less clearly understood. Here, we have dissected function several hindbrain using genetic methods. By taking advantage multiple Cre transgenic lines, induced site-specific deletions Robo3 receptor. These lines developed with disruption specific sensory, motor, sensorimotor...
Gjb2 and Gjb6, two contiguous genes respectively encoding the gap junction protein connexin26 (Cx26) connexin 30 (Cx30) display overlapping expression in inner ear. Both have been linked to most frequent monogenic hearing impairment, recessive isolated deafness DFNB1. Although there is robust evidence for direct involvement of Cx26 cochlear functions, contribution Cx30 unclear since deletion strongly downregulates both human mouse. Thus, it imperative that any role audition be clearly...
Significance Presbycusis, or age-related hearing loss, is a major public health issue and the principal potentially modifiable risk factor for dementia. It caused by environmental factors largely uncharacterized genetic factors. We compared DNA sequences across genomic coding regions between familial sporadic cases of severe presbycusis controls with normal hearing. The frequency ultrarare predicted pathogenic variants in genes known to cause dominant early-onset forms deafness was...
Bortezomib is a pivotal drug for the management of multiple myeloma. However, bortezomib neurotoxic anticancer responsible chemotherapy-induced peripheral neuropathy (CIPN). CIPN associated with psychological distress and decrease health-related quality life (HRQoL), but little known regarding bortezomib-related CIPN. This single center, cross-sectional study assessed prevalence severity sensory/motor CIPN, neuropathic pain ongoing medications, anxiety, depression, HRQoL, in myeloma patients...
Abstract Auditory neuropathies affect the spiral ganglion neurons of auditory nerve or their synapses with sensory hair cells, distorting sound information transmitted from ear to brain. Deciphering underlying pathophysiological mechanisms remains challenging owing diversity neuron subtypes and associated central circuits. An neuropathy mechanism is unraveled by investigating origin hyperexcitability in a mouse model for hereditary congenital deafness. Otogl encodes large Otogelin‐like...
A detrimental perceptive consequence of damaged auditory sensory hair cells consists in a pronounced masking effect exerted by low-frequency sounds, thought to occur when threshold elevation substantially exceeds 40 dB. Here, we identified the submembrane scaffold protein Nherf1 as hair-bundle component differentiating outer (OHCs). Nherf1(-/-) mice displayed OHC shape anomalies mid and basal cochlea, normally tuned mid- high-frequency tones, mild (22-35 dB) hearing-threshold elevations...
Understanding speech in noise is particularly difficult for individuals occupationally exposed to due a mix between noise-induced auditory lesions and energetic masking of signal. For years, the monitoring conventional audiometric thresholds has been usual way check preserve function. But highlighting supra-threshold deficits, notably understanding difficulties, pointed out need new tools. The present study aims identify most important variables that predict under-standing order suggest...
Abstract Emotional stress is a phenomenon experienced by many people at some time in their lives. Some of its early manifestations, such as unbearable loudness ambient sounds and sensations dizziness, might be linked to inner ear dysfunction. Although the supplied with substantial sympathetic innervation, previous studies have failed demonstrate any significant functional impact. We show here that awake guinea pig following unilateral ablation superior cervical ganglion, temporary threshold...
In brain-injured patients intracranial pressure (ICP) is monitored invasively by a ventricular or intraparenchymal transducer. The procedure requires specific expertise and exposes the patient to complications such as malposition, hemorrhage infection. As inner-ear fluid compartments are connected cerebrospinal space, ICP changes elicit subtle in physiology of inner ear. Notably, we previously demonstrated that phase cochlear microphonic potential (CM) generated sound stimuli rotates with...
In vertebrates, 14-3-3 proteins form a family of seven highly conserved isoforms with chaperone activity, which bind phosphorylated substrates mostly involved in regulatory and checkpoint pathways. are the most abundant protein brain abundantly found cerebrospinal fluid neurodegenerative diseases, suggesting critical role neuron physiology death. Here we show that 14-3-3eta-deficient mice displayed auditory impairment accompanied by cochlear hair cells' degeneration. We 14-3-3eta is...
In mammals, a 2-hr exposure to an octave-band noise (OBN) at 100 108 dB SPL induces loss of synaptic ribbons between inner hair cells and auditory nerve fibers with high thresholds response (hiT neurons), that encode high-intensity sounds. Here, we tackle the challenge diagnosing this synaptopathy by noninvasive functional audiological test, ultimately in humans, despite expected absence auditory-threshold elevation clear electrophysiological abnormality, hiT neuron contributions being...
Understanding speech in noise is particularly difficult for individuals occupationally exposed to due a mix between noise-induced auditory lesions and energetic masking of signal. For years, the monitoring conventional audiometric thresholds has been usual way check preserve function. But highlighting supra-threshold deficits, notably understanding difficulties, pointed out need new tools. The present study aims identify most important variables that predict under-standing order suggest...