A5103183034- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Enzyme function and inhibition
- Hepatitis B Virus Studies
- Liver physiology and pathology
- Mesenchymal stem cell research
- Liver Disease Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Hepatitis C virus research
- Organ Donation and Transplantation
- Cancer Mechanisms and Therapy
- Transplantation: Methods and Outcomes
- Pancreatitis Pathology and Treatment
- Effects of Radiation Exposure
- Genetic and Kidney Cyst Diseases
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Biliary and Gastrointestinal Fistulas
- Congenital Anomalies and Fetal Surgery
- Quinazolinone synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Autophagy in Disease and Therapy
- Neuroendocrine Tumor Research Advances
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
Bundang Jesaeng Hospital
2025
University of Cincinnati Medical Center
2025
Seoul St. Mary's Hospital
2013-2022
Catholic University of Korea
2013-2022
Oregon Health & Science University
2013-2022
VA Portland Health Care System
2020
Pusan National University Hospital
2019
Queen's University
2013
Loyola University Medical Center
2011-2012
Rush University Medical Center
2007-2008
The modified Broström procedure is an anatomic reconstruction of the lateral ankle ligaments. present study evaluated twenty-two patients (mean age = 27.2 years) with chronic instability who underwent surgical repair their ligaments using suture anchors as part procedure. All surgeries were performed by senior author (AK) on outpatient basis. At a mean follow-up 34.5 months (minimum 18 months), twenty (91%) reported good or excellent functional outcome assessed Karlsson and Peterson function...
Biliary cast syndrome (BCS), the presence of biliary casts and debris causing obstruction, occurs in 4%-18% orthotopic liver transplant (OLT) recipients. Potential consequences include cholangitis graft damage or loss. Limited data exist regarding etiology outcomes BCS. The purpose this study was to evaluate donor recipient risk factors determine impact A retrospective review 355 OLT cases identified 9 BCS patients (2.5%) diagnosed by cholangiography. Twenty-six matched controls were also...
A predictive biomarker of immune checkpoint inhibitor (ICI)-based treatments in hepatocellular carcinoma (HCC) has not been clearly demonstrated. In this study, we focused on the infiltration and programmed death ligand 1 (PD-L1) expression tumor-associated macrophages (TAMs) tumor microenvironment HCC. Immunohistochemistry demonstrated that PD-L1 was preferentially expressed CD68+ HCC, suggestive its TAMs rather than T cells or (P < 0.05). co-culture experiment using activated M2...
This study was designed to determine whether oral retinol palmitate (vitamin A) can reduce the symptoms of radiation proctopathy.A randomized, double-blind trial comparing (10,000 IU by mouth for 90 days) placebo conducted. Eligible patients were more than six months postpelvic radiotherapy and had significant as measured with Radiation Proctopathy System Assessments Scale. Nineteen randomized in total: ten nine placebo. The Scale scores before every 30 days measured. Five nonresponders...
Epidermal growth factor receptor (EGFR) is frequently amplified or mutated in non-small cell lung cancer (NSCLC). Although Fer protein-tyrosine kinase signals downstream of EGFR, its role NSCLC tumor progression has not been reported. Here, was elevated tumors compared to normal epithelium. EGFR signaling cells fosters rapid activation and increased localization lamellipodia. Stable silencing H1299 adenocarcinoma (Fer KD) caused impaired EGFR-induced lamellipodia formation control cells. KD...
Regenerative medicine is expected to offer an alternative liver transplantation for treating diseases in the future, with one significant challenge being establishment of effective stem cell administration route. This study assessed antifibrogenic effects adipose-derived cells (ASCs) a fibrosis mouse model, focusing on 2 methods delivery: intravenous injection and scaffold implantation. An extracellular matrix mimic was utilized culturing peroxisome proliferator-activated receptor gamma...
Despite many efforts to effectively treat PDAC, PDAC carries one of the highest mortality rates all major cancers. Thus, there is a critical unmet need develop novel approaches improve clinical outcome PDAC. It well known that cancers, including generate local TME allows cancer escape normal immune surveillance. Phosphatidylserine (PS), negatively charged phospholipid abundant on cell membrane and with actions promote secretion immunomodulatory proteins, may provide mechanism regulate TME....
The purpose of this study is to describe a single operator's experience with the feasibility and safety transradial access in conventional cerebral angiography. 153 patients were enrolled consecutively. Among them, 20 not suitable for access. A Simmons catheter was used. Haemostasis achieved using compressive dressing wrist. We analysed success rates arterial puncture successful catheterization rate each supra-aortic vessel as well all complications. 96.3%. vessels catheterized 99.2%...
LT, liver transplantation; HCC, hepatocellular carcinoma; IS, immunosuppressants; DC, dendritic cells; Treg, regulatory T; Th17, T helper 17; AST, aspartate transaminase; ALT, alanine OUT, operational taxonomic unit; LEfSe, linear discriminant analysis effect size; LDA, analysis; IL, interleukin; TGF, transforming growth factor; GM-CSF, granulocyte-macrophage colony-stimulating IFN, interferon; TNF-α, tumor necrosis factor-α; MIP-1α, macrophage inflammatory protein-1α; IP-10, interferon...
Almost all liver diseases are known to be accompanied by increased levels of reactive oxygen species (ROS), regardless the cause disorder. However, little is about role hypoxic conditioned media (HCM) in view pro-oxidative/antioxidative balance.Normoxic (NCM) and HCM were obtained after culturing adipose-derived stem cells 20% O2 or 1% for 24 hours, respectively. Their effects on expression various markers reflecting balance investigated both vitro (thioacetamide-treated AML12 cells) vivo...
Abstract The limitations of stem cells have led researchers to investigate the secretome, which is secretory materials in cells, since principal mechanism action mediated by secretome. In this study, we determined antifibrotic potential secretome released from miR-150-transfected adipose-derived stromal (ASCs). ASCs that were transfected with miR-150 was obtained (referred as secretome). To validate effects generated vitro and vivo models liver fibrosis treating human hepatic stellate (LX2...
BACKGROUNDRecently, the exclusive use of mesenchymal stem cell (MSC)-secreted molecules, called secretome, rather than cells, has been evaluated for overcoming limitations cell-based therapy, while maintaining its advantages.However, naïve secretome may not fully satisfy specificity each disease.Therefore, it appears to be more advantageous functionally reinforced through a series processes involving physico-chemical adjustments or genetic manipulation secretome. AIMTo determine therapeutic...
Although methyl-tertiary butyl ether (MTBE) is the only clinical topical agent for gallstone dissolution, its use limited by side effects mostly arising from a relatively low boiling point (55 °C). In this study, we developed gallstone-dissolving compound containing an aromatic moiety, named 2-methoxy-6-methylpyridine (MMP) with higher (156 °C), and compared effectiveness toxicities MTBE.The dissolubility of MTBE MMP in vitro was determined placing human gallstones glass containers either...
Background: Mammalian target of rapamycin (mTOR) inhibitors, such as everolimus and sirolimus, may be efficacious in preserving renal function liver transplantation (LT) recipients while preventing hepatocellular carcinoma (HCC) recurrence. Materials Methods: In this study, we retrospectively evaluated the safety, efficacy, renoprotective effects mTOR inhibitors LT recipients. Among 84 patients enrolled, inhibitor was commenced during first year after LT. Renal measured by estimated...
This paper aims to validate if intrapancreatic injection of penicillin G can enhance hardness and suture holding capacity (SHC) the pancreas through prompting fibrosis process. Soft pancreatic texture is constantly mentioned as one most contributory predictors postoperative fistula (POPF). has poor SHC higher incidence parenchymal tearing, frequently leading POPF. From a library 114 antibiotic compounds, we identified that substantially enhanced in experimental mice. Specifically, injected...
Recently, the exclusive use of mesenchymal stem cell (MSC)-secreted molecules, named as secretome, have been evaluated for overcoming limitations cell-based therapy while maintaining its advantages.To improve cell-free by adding disease-specificity through stimulation MSCs using disease-causing materials.We collected secretory materials (named inducers) released from AML12 hepatocytes that had pretreated with thioacetamide (TAA) and generated TAA-induced secretome (TAA-isecretome) after...
BACKGROUND Hepatic artery reconstruction during living donor liver transplantation is a critical step. To perform this risky procedure, microscope has been used. However, it takes long time to complete the procedure and steep learning curve. Recently, some transplant surgeons have performed using surgical loupe. We conducted study compare outcomes after hepatic versus MATERIAL AND METHODS retrospectively reviewed of 300 patients at our institution from April 2014 July 2020. From September...
Secretome refers to the total set of molecules secreted or surface-shed by stem cells. The limitations cell research have led numerous investigators turn their attention use secretome instead In this study, we intended reinforce antifibrotic properties released from adipose-derived cells (ASCs) transfected with miR-214.We generated miR-214-transfected ASCs, and extracted (miR214-secretome) conditioned media ASCs through a series ultrafiltrations. Subsequently, intravenously injected...
Several studies have indicated that cholestatic liver damage involves mitochondria dysfunction. However, the precise mechanism by which hydrophobic bile salts cause mitochondrial dysfunction is not clear. In this study, we intended to determine pathogenesis of injury associated with peroxisome proliferator-activated receptor-γ co-activator 1α (PGC-1α). A mouse model disease was generated surgical ligation duct (BDL), and a fibrosis developed through serial administration thioacetamide. After...