A5041692638- Rheumatoid Arthritis Research and Therapies
- Inflammatory Myopathies and Dermatomyositis
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Adenosine and Purinergic Signaling
- interferon and immune responses
- Immune Cell Function and Interaction
- Signaling Pathways in Disease
- Immunotherapy and Immune Responses
- Autoimmune and Inflammatory Disorders Research
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Systemic Sclerosis and Related Diseases
- Osteoarthritis Treatment and Mechanisms
- Inflammasome and immune disorders
- Skin Diseases and Diabetes
- Ocular Diseases and Behçet’s Syndrome
- Viral Infections and Immunology Research
- Inflammatory mediators and NSAID effects
- Cancer Immunotherapy and Biomarkers
- Monoclonal and Polyclonal Antibodies Research
- Eosinophilic Disorders and Syndromes
- Systemic Lupus Erythematosus Research
- Chemokine receptors and signaling
Chungnam National University Hospital
2016-2025
Chungnam National University
2015-2025
RELX Group (Netherlands)
2023
National University College
2018
New Generation University College
2018
Korea University
2016
Beth Israel Deaconess Hospital
2008
Beth Israel Deaconess Medical Center
2008
Harvard University
2008
Wonkwang University
2003
In vascular smooth muscle cells (VSMCs), induction of the heme oxygenase-1 (HO-1) confers protection against cellular proliferation mainly via its up-regulation cyclin-dependent kinase inhibitor p21(WAF1/CIP1) that is involved in negative regulation proliferation. present study, we investigated whether phytochemical curcumin and metabolite tetrahydrocurcumin could induce HO-1 expression growth inhibition rat VSMCs and, if so, their antiproliferative effect be mediated expression. At...
Zinc metabolically reprograms monocytes and macrophages to promote inflammation in rheumatoid arthritis.
Background/Objectives: Ferroptosis is a type of regulated cell death that involves iron-dependent accumulation lipid peroxides. Because fibroblast-like synoviocytes (FLSs) in patients with rheumatoid arthritis (RA) have hyperplastic and inflammatory phenotype, selective induction FLS considered potential treatment strategy for RA. Liver kinase B1 (LKB1)-activated AMP-activated protein (AMPK) signaling regulates the inflammation migration RA FLSs, contributing to pathogenesis. Here, we aimed...
Rheumatoid arthritis (RA) is an autoimmune disease that starts with decreased tolerance to modified self-antigens and eventually leads synovitis destruction of bone cartilage. Age a risk factor for developing RA. Major changes in the immune system come age due chronic oxidative stress on deoxyribonucleic acid (DNA) damage pathway, somatic mutation, modifications autoantigens, T cell activation fibroblast-like synoviocytes (FLS). Reactive oxygen species (ROS) generated by nicotinamide adenine...
Reactive oxygen species (ROS) regulate the migration and invasion of fibroblast-like synoviocytes (FLS), which are key effector cells in rheumatoid arthritis (RA) pathogenesis. Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) induces ROS generation and, consequently, enhances cell migration. Despite important interrelationship between RA, FLS, ROS, effect NOX4 on RA pathogenesis remains unclear.FLS isolated from (n = 5) osteoarthritis (OA, n patients were stimulated with...
Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) patients have increased reactive oxygen species (ROS) levels and an impaired redox balance compared with FLS from control patients. Liver kinase B1 (LKB1) plays a key role ROS scavenging cellular metabolism various cancers. Here, we aimed to determine the specific mechanism of LKB1 RA pathogenesis. were obtained (n = 10). siRNA-induced deficiency via NADPH oxidase 4 (NOX4) upregulation. migration expression inflammatory factors,...
Rheumatoid arthritis (RA) is a common autoimmune disease characterized by immune cell infiltration of the synovium, leading to loss cartilage, bone, and joint function. Although regulatory T (Treg) cells are thought modulate initiation progression RA, consensus has yet be reached regarding function composition Treg in RA patients. To address these discrepancies, we analyzed not only total frequency but also that subpopulations peripheral blood patients healthy controls flow cytometry. We...
An in vitro transcription system based on cytidine-free cassette was developed for the late 39k gene and very polyhedrin of Autographa californica nuclear polyhedrosis virus (AcNPV). Optimization conditions revealed that a preincubation step not required promoters, although essential efficient from an early promoter. The constructs were actively transcribed by extracts prepared AcNPV-infected Spodoptera frugiperda cells at 12 or 36 h postinfection but uninfected infected harvested during...
The production and oxidation mechanism of reactive oxygen species (ROS) are out balance in rheumatoid arthritis (RA). However, the correlation between ROS T cell subsets RA remains unclear. Peripheral blood mononuclear cells (PBMCs) from patients with (n = 40) healthy controls 10) were isolated whole samples. Synovial tissues 3) synovial fluid obtained RA. repartition expression cytokines examined according to severity. Fibroblast-like synoviocytes (FLSs) stimulated PBMCs...
This study aimed to examine the role of CD70, which is highly expressed on fibroblast-like synoviocytes (FLS), in rheumatoid arthritis (RA) patients. FLS isolated from RA (n = 14) and osteoarthritis (OA, n 4) patients were stimulated with recombinant interleukin-17 (IL-17; 5 ng/mL) tumor necrosis factor alpha (TNF-α; for 24 h. Expression CD27/soluble CD27 (sCD27), hypoxia-inducible factor-2 (HIF-2α) was analyzed by RT-qPCR, flow cytometry, ELISA assays, respectively. Reactive oxygen species...
Objectives: This study aims to investigate the role of cluster differentiation 14 (CD14) expressed monocytes and soluble CD14-mediated pathway in synovial inflammation knee osteoarthritis (OA). Patients methods: Between May 2012 July 2013, a total 35 patients with OA (9 males, 26 females; mean age: 66.3±8.8 years; range, 52 79 years) were included this cross-sectional study. Synovial fluid was obtained from joints patients. The CD14 + mononuclear cells (SFMCs) isolated using MACS....
Pulmonary arterial hypertension (PAH) is a major cause of morbidity and mortality among patients with systemic sclerosis (SSc). Early detection prompt treatment PAH associated SSc (SSc-PAH) result in better prognosis. We conducted echocardiographic study to presume the prevalence Korean adult diagnose SSc-PAH their early stages right heart catheterization (RHC).We performed free charge including 37 at Chungnam National University Hospital. The possibility determined by estimation pulmonary...
Anti-transcriptional intermediary factor 1 (TIF1) antibody is associated with idiopathic inflammatory myopathies (IIMs). The aim of this study was to investigate the expression TIF1s in IIMs.TIF1α, β or γ skin and muscle patients controls studied by immunohistochemistry. Serum myositis-specific autoantibodies were detected immunoblot.TIF1α expressed most dermatomyositis (DM) but not (80% vs 0%, P < 0.001). TIF1β all tissues controls. TIF1γ DM compared (42.1% = 0.039) tubuloreticular bodies...
Dermatomyositis (DM) and polymyositis (PM) are representative idiopathic inflammatory myopathies characterized by symmetric progressive proximal muscle weakness. Especially, DM is identified characteristic skin lesions has many extramuscular manifestations including various cardiac abnormalities, interstitial lung disease, malignancy. However, involvement of peripheral nervous system in DM/PM very rare less known. The term "Neuromyositis" was introduced Senator 1893 to describe the...
Purpose Although cardiac manifestation of Behçet disease ( BD ) has been described in sporadic reports, its timely diagnosis remains difficult. The objective this study was to describe early manifestations . We also performed a comprehensive classification systemic activity and compared their manifestations. Methods A prospective screening using speckle tracking echocardiography 85 patients with who had no history heart disease. After excluding subjects left ventricular LV ejection fraction...
<h3>Background</h3> Reactive oxygen species (ROS) is produced during metabolism of Oxygen. ROS important in cell signalling and homeostasis. Production can be elevated stressful condition. Oxidative stress has been known to related with the disease like infection malignancy. NADPH oxidases (Nox) are membrane proteins which produce ROS. <h3>Objectives</h3> In this study we aimed investigate role Nox rheumatoid arthritis (RA) associated production <h3>Methods</h3> Granulocyte macrophage...
Background: Liver kinase B1 (LKB1) is known as a tumor suppressor gene and also inhibits reactive oxygen species (ROS) levels. Intracellular ROS are catalyzed by the enzyme complex nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX). We previously reported that NOX4 induced migration invasion of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA). Although LKB1 expected to alleviate synovial inflammation through regulation, role RA has not been examined. Objectives:...
There is growing evidence that apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) regulates inflammatory responses. Rheumatoid arthritis (RA) an autoimmune disease, which characterized with synovitis and joint destruction. Therefore, this study was planned to investigate the relationship between APE1/Ref-1 RA. Serum synovial fluid (SF) were collected from 46 patients RA, 45 osteoarthritis (OA), 30 healthy control (HC) patients. The concentration of in serum or SF measured using...