A5068047622- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Immune cells in cancer
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Atherosclerosis and Cardiovascular Diseases
- Telomeres, Telomerase, and Senescence
- Nitric Oxide and Endothelin Effects
- Viral Infections and Immunology Research
- Chemokine receptors and signaling
- Iron Metabolism and Disorders
- Hematopoietic Stem Cell Transplantation
- Whipple's Disease and Interleukins
- Inflammasome and immune disorders
- Platelet Disorders and Treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell Adhesion Molecules Research
- Pharmacological Effects of Medicinal Plants
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Aluminum toxicity and tolerance in plants and animals
Seoul National University
2015-2022
National University College
2015
New Generation University College
2015
Progressive renal failure causes uremia-related immune dysfunction, which features a chronic inflammatory milieu. Given the central role of end-stage disease (ESRD)-related dysfunction in pathogenesis cardiovascular diseases (CVDs), much attention has been focused on how uremic toxins affect cellular immunity and mechanisms underlying atherosclerosis ESRD patients. Here, we investigated characteristics monocytes CD4+ T cells patients responses induced by indoxyl sulfate (IS), key toxin,...
Zinc metabolically reprograms monocytes and macrophages to promote inflammation in rheumatoid arthritis.
Summary Zinc is an essential trace element that plays pivotal roles in multiple facets of the immune system. Besides its catalytic and structural roles, zinc also functions as intracellular signalling molecule, changes levels can cause both direct indirect modulation responses. Further, cytoplasmic bioavailable cells are largely influenced by many extracellular stimuli. Here we provide evidence represses memory T helper type 17 responses humans inhibiting interleukin‐1 β ( IL ‐1 )‐mediated...
The essential microelement zinc plays immunoregulatory roles via its ability to influence signaling pathways. Zinc deficiency impairs overall immune function and resultantly increases susceptibility infection. Thus, is considered as an immune-boosting supplement for populations with hypozincemia at high-risk Besides role a structural cofactor of many proteins, also acts intracellular messenger in cell signaling. T-cell activation instructs influx from extracellular subcellular sources...
ABSTRACT The essential micronutrient zinc plays regulatory roles in immune responses through its ability to affect signaling pathways. In activated monocytes/macrophages, networks mediate metabolic reprogramming order meet the demands of participating responses. Despite known immunoregulatory roles, effect on monocytes/macrophages remains unclear. Here, we demonstrate that cytoplasmic bioavailable is for regulating IL-1β production human downstream mTORC1-induced glycolysis. level was...
Abstract In the ESRD patients, a major cause of death is cardiovascular disease (CVD) and its pathologic processes have been suggested to link uremia-related chronic inflammation. Although concept ESRD-related immune dysfunction well-accepted, little known about how uremic toxins affect cellular immunity involved with pathogenesis CVD in patients. Thus, we investigated phenotypic functional features CD4 T cells monocytes patients their responses mediated by indoxyl sulfate (IS), key toxin...
Abstract B7-H3, a newly identified B7 family member, has functional duality as T-cell costimulator and coinhibitor that fine-tunes mediated immune responses. Given B7-H3 expression on human monocytes dendritic cells is enhanced by inflammatory cytokines, its potential inmmunoregulatory role at sites of inflammation been suggested. Monocytes also play crucial roles in the pathophysiology various autoimmune diseases. However, immunological RA not defined. We aimed to investigate possible...
Abstract Pediatric and adolescent patients in need of allogeneic hematopoietic stem cell transplantation (HSCT) generally receive cells from older, unrelated or parental donors when a sibling donor is not available. Despite encouraging clinical outcomes, it has been suggested that immune reconstitution accompanied by increased replicative stress large difference between recipient age may worsen immunosenescence pediatric recipients. Therefore, this study paired samples were collected at the...
Abstract Zinc is an essential micronutrient that plays critical roles in multiple facets of biological processes, including growth, development, proliferation, and differentiation. Since dysregulated zinc homeostasis impairs overall immune function resultantly, increases susceptibility to infection, much attention has been recently paid immunomodulatory cells. Rapid efficient production proinflammatory cytokines, such as IL-1β TNF-α, a primary effect monocytes/macrophages for host defense....
Abstract Monocytes are important cellular effectors of innate immune defense. In humans, circulating monocytes heterogeneous and can be divided into three distinct subsets based on CD14 CD16 expression. The expansion “intermediate” CD14+CD16+ is well reported in many chronic inflammatory conditions such as rheumatoid arthritis (RA). However, the mechanism underlying induction role remain unclear. ADP-treated autologous platelets induced expression by highly purified “conventional” CD14+CD16−...