A5053643671- Neuroscience and Neuropharmacology Research
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Epilepsy research and treatment
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Adenosine and Purinergic Signaling
- Ion channel regulation and function
- Mitochondrial Function and Pathology
- Cell death mechanisms and regulation
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Biochemical Analysis and Sensing Techniques
- Immune Cell Function and Interaction
- Treatment of Major Depression
- Genetics and Neurodevelopmental Disorders
University of Florida
2023-2024
Scripps Research Institute
2018-2020
Kunming Institute of Zoology
2010-2015
Chinese Academy of Sciences
2010-2015
University of Hong Kong
2014-2015
University of Chinese Academy of Sciences
2013-2015
Abstract Mutations that inactivate negative translation regulators cause autism spectrum disorders (ASD), which predominantly affect males and exhibit social interaction communication deficits repetitive behaviors. However, the cells ASD through elevated protein synthesis resulting from these mutations remain unknown. Here we employ conditional overexpression of initiation factor eIF4E to increase in specific brain cells. We show exaggerated microglia, but not neurons or astrocytes, leads...
The TrkB receptor is critical for the control of energy balance, as mutations in its gene (NTRK2) lead to hyperphagia and severe obesity. main neural substrate mediating appetite-suppressing activity TrkB, however, remains unknown. Here, we demonstrate that selective Ntrk2 deletion within paraventricular hypothalamus (PVH) leads hyperphagic Furthermore, chemogenetic activation or inhibition TrkB-expressing PVH (PVHTrkB) neurons suppresses increases food intake, respectively. PVHTrkB project...
Abstract Caspase-2 is the most evolutionarily conserved member in caspase family of proteases and constitutively expressed cell types including neurons; however, its physiological function remains largely unknown. Here we report that caspase-2 plays a critical role synaptic plasticity cognitive flexibility. We found deficiency led to deficits dendritic spine pruning, internalization AMPA receptors long-term depression. Our results indicate degrades Rictor, key mTOR complex 2 (mTORC2)...
Abstract Prenatal opiate exposure causes a series of neurobehavioral disturbances by affecting brain development. However, the question whether prenatal increases vulnerability to memory‐related neuropsychiatric disorders in adult offspring remains largely unknown. Here, we found that rats prenatally exposed morphine ( PM ) showed impaired acquisition but enhanced maintenance contextual fear memory compared with control animals were saline PS ). The impairment was rescued increasing...
Anxiety disorders are associated with body weight changes in humans. However, the mechanisms underlying anxiety-induced remain poorly understood. Using Emx1Cre/+ mice, we deleted gene for brain-derived neurotrophic factor (BDNF) cortex, hippocampus, and some amygdalar subregions. The resulting mutant mice displayed impaired GABAergic transmission elevated anxiety. They were leaner when fed either a chow diet or high-fat diet, owing to higher sympathetic activity, basal metabolic rate, brown...
Abstract The emotion of despair that occurs with uncontrollable stressful event is probably retained by memory, termed despair-associated although little known about the underlying mechanisms. Here, we report forced swimming (FS) no hope to escape, but not hopefully escapable (ES), enhances hippocampal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-dependent GluA1 Ser831 phosphorylation (S831-P), induces a slow-onset CA1 long-term potentiation (LTP) in freely moving...
SUMMARY Anxiety disorders are associated with body weight changes in humans. However, mechanisms underlying anxiety-related remain poorly understood. Using Emx1 Cre/+ mice, we deleted the gene for brain-derived neurotrophic factor (BDNF) cortex, hippocampus, and some parts of amygdala. The resulting mutant mice displayed elevated anxiety levels were markedly lean when fed either chow diet or high-fat (HFD). showed higher sympathetic activity, thermogenesis lipolysis both brown white adipose...
Abstract At the center of hippocampal tri-synaptic loop are synapses formed between mossy fiber (MF) terminals from granule cells in dentate gyrus (DG) and proximal dendrites CA3 pyramidal neurons. However, molecular mechanism regulating development function these is poorly understood. In this study, we showed that neurotrophin-3 (NT3) was expressed nearly all mature but not cells. We selectively deleted NT3-encoding Ntf3 gene DG during 1 st two postnatal weeks to generate a conditional...
Anxiety disorders are associated with body weight changes in humans. However, mechanisms underlying anxiety-related remain poorly understood. Using Emx1Cre/ mice, we deleted the gene for brainderived neurotrophic factor (BDNF) cortex, hippocampus, and some parts of amygdala. The resulting mutant mice displayed elevated anxiety levels were markedly lean when fed either chow diet or highfat (HFD). showed higher sympathetic activity, thermogenesis lipolysis both brown white adipose tissues,...