A5018558120- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neuropharmacology Research
- Trauma and Emergency Care Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Traumatic Brain Injury Research
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hepatocellular Carcinoma Treatment and Prognosis
- Neurogenesis and neuroplasticity mechanisms
- Liver Disease Diagnosis and Treatment
- Extracellular vesicles in disease
- Acute Ischemic Stroke Management
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cellular transport and secretion
- Melanoma and MAPK Pathways
- Optical Imaging and Spectroscopy Techniques
- Liver Disease and Transplantation
- Salivary Gland Tumors Diagnosis and Treatment
- Immune cells in cancer
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
- Mitochondrial Function and Pathology
- Receptor Mechanisms and Signaling
Huashan Hospital
2015-2024
Fudan University
2013-2024
Duke-NUS Medical School
2014-2023
Zhejiang Chinese Medical University
2023
Shanghai Clinical Research Center
2022
Shanghai Center for Brain Science and Brain-Inspired Technology
2022
Tianjin Third Central Hospital
2010-2021
Tianjin Medical University
2010-2021
West China Hospital of Sichuan University
2003-2020
Sichuan University
2003-2020
Hyperexcitable neurons in brain organoids Individuals with Angelman syndrome experience intellectual disability and seizures throughout their lives. In this condition, ubiquitin-mediated degradation of a key potassium channel is disrupted, allowing for the neuronal excitability network synchronization that leads to seizure. Sun et al. used organoid technology study what happens human mutation ubiquitin ligase implicated syndrome. these vitro models mouse model syndrome, antagonists...
The MAM domain-containing GPI anchor proteins MDGA1 and MDGA2 are Ig superfamily adhesion molecules composed of six IG domains, a fibronectin III domain, anchor. MDGAs contribute to the radial migration positioning subset cortical neurons during early neural development. However, continue be expressed in postnatal brain, their functions development remain unknown. Here, we demonstrate that specifically with nanomolar affinity bind neuroligin-2, cell-adhesion molecule inhibitory synapses, but...
Gamma-aminobutyric acid (GABA)-releasing interneurons play an important modulatory role in the cortex and have been implicated multiple neurological disorders. Patient-derived could provide a foundation for studying pathogenesis of these diseases as well identifying potential therapeutic targets. Here, we identified set genetic factors that robustly induce human pluripotent stem cells (hPSCs) into GABAergic neurons (iGNs) with high efficiency. We demonstrated iGNs express neurochemical...
Coagulopathy is commonly observed after traumatic brain injury (TBI). However, it not known whether using the standard independent predictors in conjunction with coagulation tests would improve their prognostic value. We determined incidence of TBI-associated coagulopathy patients isolated TBI (iTBI), evaluated value for in-hospital mortality, and tested predictive power mortality iTBI. conducted a retrospective, observational database study on 2319 consecutive iTBI who attended Huashan...
Multiple loss-of-function mutations in TRIAD3 (a.k.a. RNF216) have recently been identified patients suffering from Gordon Holmes syndrome (GHS), characterized by cognitive decline, dementia, and movement disorders. TRIAD3A is an E3 ubiquitin ligase that recognizes facilitates the ubiquitination of its target for degradation ubiquitin-proteasome system (UPS). Here, we demonstrate two these missense substitutions (R660C R694C) could not regulate their neuronal target, activity-regulated...
Although intracranial pressure (ICP) monitoring of patients with severe traumatic brain injury (TBI) is recommended by the Brain Trauma Foundation, any benefits remain controversial.To evaluate effects ICP on mortality and functional outcomes in diffuse TBI.Data were collected TBI (Glasgow Coma Scale [GCS] score admission <9 Marshall Class II-IV) treated from January 2012 to December 2013 24 hospitals (17 level I trauma centers 7 II centers) 9 Chinese provinces. We evaluated impact 6-month...
Genetic variations in dystrobrevin binding protein 1 (DTNBP1 or dysbindin-1) have been implicated as risk factors the pathogenesis of schizophrenia. The encoded dysbindin-1 functions regulation synaptic activity and synapse development. Intriguingly, a loss function mutation Dtnbp1 mice disrupted both glutamatergic gamma-aminobutyric acidergic transmission cerebral cortex; pyramidal neurons displayed enhanced excitability due to reductions inhibitory inputs. However, mechanism by which...
Aconitine (ACO) is well-known for causing lethal ventricular tachyarrhythmias. While cardiac Na+ channel opening during repolarization has long been documented in animal myocytes, the cellular effects and mechanism of ACO human remain unexplored. This study aimed to assess proarrhythmic induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). concentration-dependently (0.3 ~ 3.0 μM) shortened action potentials (AP) durations (APD) ventricular-like hiPSC-CMs by > 40% delayed...
Abstract Background Fibrinogen may play an important role in the survival of trauma patients; however, its traumatic brain injury (TBI) and correlation with disease prognosis remain poorly understood. The aims this study were to determine incidence TBI-associated hypofibrinogenemia patients TBI evaluate prognostic value fibrinogen level respect mortality clinical outcomes. Methods A total 2570 consecutive retrospectively studied. Prognostic evaluations determined using Glasgow Outcome Score...
Background and Purpose Recent evidence has supported the neuroprotective effect of bpV (pic), an inhibitor phosphatase tensin homolog deleted on chromosome 10 (PTEN), in models ischemic stroke. However, whether PTEN inhibitors improve long-term functional recovery after traumatic brain injury (TBI) affects blood barrier (BBB) permeability need further elucidation. The present study was performed to address these issues. Methods Adult Sprague-Dawley rats were subjected fluid percussion (FPI)...
Objectives: To evaluate the efficacy of traumatic brain injury management guided by intracranial pressure monitoring and to explore specific subgroups for which might be significantly associated with improved outcomes based on a classification various pathophysiologies using clinical features CT scans. Design: Retrospective observational multicenter study. Setting: Twenty-two hospitals (16 level I trauma centers six II centers) in nine provinces China. Patients: Moderate or severe patients...
Nosocomial meningitis and ventriculitis (MEN) are serious complications in neuro-critical care unit (NCCU) patients. Few data available on the risk factors mortality rates among NCCU patients with these disorders caused by multi-drug-resistant (MDR) pathogens. Our aim was to identify for MEN such pathogens in-hospital deaths critically ill neurologic evaluate impact of empirical combination antibiotic therapy (ECAT) outcomes patients.We conducted a retrospective study having nosocomial who...
Deferoxamine mesylate can cross the blood-brain barrier and reduce iron accumulation in nervous tissue; moreover, it has a variety of neuroprotective functions addition to complexing with ions. Such chelators are expected become new treatment option for intracerebral hemorrhage. This study evaluated effects deferoxamine on hematoma edema absorption after traumatic hemorrhage (TICH), provides clinical evidence TICH mesylate. Patients isolated TICH, confirmed by head computed tomography, were...
Objective: To prospectively investigate the predictive value of initial intracranial pressure (ICP) for refractory hypertension and outcomes in persons with diffuse traumatic brain injury (TBI).
Abstract The emotion of despair that occurs with uncontrollable stressful event is probably retained by memory, termed despair-associated although little known about the underlying mechanisms. Here, we report forced swimming (FS) no hope to escape, but not hopefully escapable (ES), enhances hippocampal α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-dependent GluA1 Ser831 phosphorylation (S831-P), induces a slow-onset CA1 long-term potentiation (LTP) in freely moving...
Abstract To address existing limitations in live neuron imaging, we have developed NeuO , a novel cell‐permeable fluorescent probe with an unprecedented ability to label and image neurons selectively over other cells the brain. enables robust imaging isolation vivo vitro across species; its versatility ease of use sets basis for development myriad neuronal targeting applications.