A5026999712- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Total Knee Arthroplasty Outcomes
- Orthopedic Surgery and Rehabilitation
- Bone fractures and treatments
- Hip disorders and treatments
- Reconstructive Surgery and Microvascular Techniques
- Bone and Joint Diseases
- Hip and Femur Fractures
- Facial Nerve Paralysis Treatment and Research
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- Hemophilia Treatment and Research
- Peripheral Nerve Disorders
- Musculoskeletal synovial abnormalities and treatments
- Rheumatoid Arthritis Research and Therapies
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Nerve Injury and Rehabilitation
- Diabetic Foot Ulcer Assessment and Management
- Ear Surgery and Otitis Media
- Elbow and Forearm Trauma Treatment
- Bone health and osteoporosis research
- Osteoarthritis Treatment and Mechanisms
- Reconstructive Facial Surgery Techniques
Kyung Hee University
2012-2024
Kyung Hee University Medical Center
1992-2024
Weatherford College
2023
Chung-Ang University Hospital
2020
Kyung Hee University Hospital at Gangdong
2011-2019
Kyung Hee University Dental Hospital
1997-2014
Kyung Hee University East-West Neo Medical Center
2007-2010
Addis Ababa University
1993
Abstract Introduction The objective of this study was to determine the anti-inflammatory, nociceptive, and antiarthritic effects piperine, active phenolic component in black pepper extract. Methods vitro anti-inflammatory activity piperine tested on interleukin 1β (IL1β)-stimulated fibroblast-like synoviocytes derived form patients with rheumatoid arthritis. levels IL6, matrix metalloproteinase (MMPs), cyclo-oxygenase 2 (COX-2), prostaglandin E2 (PGE ) were investigated by ELISA RT-PCR...
Identification of the factors associated with improved facial nerve function after treatment Bell palsy is important to provide patients early and effective treatment.To identify that are outcomes in palsy.This retrospective cohort study included 1364 treated at outpatient clinic Department Otolaryngology Kyung Hee University Hospital, Seoul, Republic Korea, between January 1, 2005, December 31, 2017. The medical records admitted this hospital for management acute were reviewed by 3...
Abstract Introduction The role of adiponectin in the pathogenesis arthritis is still controversial. This study was performed to examine whether involved joint inflammation and destruction rheumatoid (RA) relation expression vascular endothelial growth factor (VEGF) matrix metalloproteinases (MMPs). Methods Synovial cells from RA patients were treated with or interleukin (IL)-1β for 24 hours. culture supernatant collected analyzed levels IL-6, IL-8, prostaglandin E 2 (PGE ), VEGF, MMPs by...
This study aimed to determine whether taurine supplementation improves metabolic disturbances and diabetic complications in an animal model for type 2 diabetes. We investigated has therapeutic effects on glucose metabolism, lipid Otsuka Long-Evans Tokushima fatty (OLETF) rats with long-term duration of Fourteen 50-week-old OLETF chronic diabetes were fed a diet supplemented (2%) or non-supplemented control 12 weeks. Taurine reduced blood levels over weeks, improved OGTT outcomes at 6 weeks...
Reconstructive acetabular osteotomy is a well established and effective procedure in the treatment of dysplasia. However, dysplasia frequently accompanied by intra-articular pathology such as labral tears. We intended to determine whether concomitant hip arthroscopy with peri-acetabular rotational could identify treat associated thereby produce favourable outcome. prospectively evaluated 43 consecutive hips treated combined osteotomy. Intra-operative arthroscopic examination revealed lesions...
Abstract Background Age-related obesity and body composition changes include loss of muscle mass increased fat. This study aimed to investigate sex differences in the impact sarcopenia, defined by Asian Working Group for Sarcopenia (AWGS), on Korean older adults. Methods In this 2-year longitudinal study, 3014 participants were excluded based AWGS sarcopenia parameters (if any one sarcopenic parameter criteria was satisfied), including low handgrip strength (HGS), appendicular skeletal index...
This study was performed to evaluate the contribution of adiponectin production interleukin (IL)-6, IL-8, vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-1 and MMP-13 in human cells osteoblasts arthritic joints. Cultured umbilical (HUVECs) were stimulated with (1 or 10 μg ml(-1)) IL-1β (0.1 ng presence absence hypoxia for 24 h. The protein expression patterns examined by analyzing culture supernatants using enzyme-linked immunosorbent assay (ELISA). Adiponectin...
The PD-1 (programmed death 1) molecule is a negative regulator of T cells. PDCD1 cell has been reported to have genetic association in systemic lupus erythematosus and rheumatoid arthritis Caucasians. However, there are no reports on the between this gene ankylosing spondylitis (AS). present study investigated polymorphisms haplotypes with AS Korean population sample. In case-control study, two single-nucleotide polymorphisms, PD-1.5 C/T PD-1.9 T/C, were genotyped 95 patients 130 healthy...
A variety of joint-preserving operations have been devised to preserve the necrotic femoral head with varying success. Since 1979, authors studied effectiveness vascularized fibula grafting in treatment osteonecrosis (ONFH) for joint preservation. Eighty-one 121 hips a minimum follow-up period ranged from three years ten eight months (mean, five two months). All patients were evaluated clinically and roentgenographically on basis causes stages disease. In clinical assessment, 60 (74%) 81...
To determine whether adiponectin may have synergistic effects in combination with the proinflammatory cytokine interleukin (IL)-1β regarding production of mediators during arthritic joint inflammation, synovial cells from rheumatoid arthritis (RA) patients were treated adiponectin, IL-1β, and their for 24 h. Culture supernatant was collected analyzed by enzyme-linked immunosorbent assay levels IL-6, IL-8, prostaglandin E2 (PGE2), vascular endothelial growth factor (VEGF), matrix...
Objectives. To further understand the expression regulation of MMP-1 and MMP-13 under physiological pathological conditions, we investigated combined effects hypoxia pro-inflammatory stimuli on in rheumatoid synovial fibroblasts. Methods. Synovial fibroblasts were cultured either hypoxic or normoxic conditions presence IL-1β stimulation. The culture supernatant was analysed for secreted levels VEGF, MMP-13. Their gene quantified with real-time semi-quantitative PCR. Another group cells...
Abstract Background Obesity is a chronic disease that causes various medical health problems, increases morbidity, and reduces the quality of life. (especially central obesity) in older adults expected to act with development sarcopenia. However, relationship between obesity, sarcopenia remains controversial. This study aimed investigate impact obesity on Methods In this cross-sectional study, we used data from Korean Frailty Aging Cohort Study; 1,827 community-dwelling (883 men 944 women)...
Abstract Studies on the trends in prevalence of rheumatoid arthritis (RA) and osteoarthritis (OA) are limited, particularly during COVID-19 pandemic. This study aimed to analyze temporal trend RA OA South Korean adults from 1998 2021, including pandemic period. The Korea National Health Nutrition Examination Survey (KNHANES) data aged ≥ 19 years were analyzed investigate 2021. compared by years, β diff (β difference) was calculated. Odds ratios (ORs) computed for each disease examine changes...
The objective of this study was to assess the cross-sectional areas (CSA) lumbar paraspinal muscles and their fatty degeneration in adults with degenerative spondylolisthesis (DLS) diagnosed chronic radiculopathy, compare them those same age- sex-related groups evaluate correlations changes observed on magnetic resonance imaging (MRI). This retrospective included 62 female patients aged 65–85 years, who were polyradiculopathy. divided into two groups: 30 32 without spondylolisthesis. We...
To establish whether clinical prognostic factor outcomes differed based on the initial severity of facial weakness and to determine association between favorable outcomes. This retrospective cohort study analyzed all patients with Bell's palsy who visited outpatient clinic our university hospital from 1 January 2005 through 31 2021. The primary outcome was rate recovery at 6 months, evaluated separately in House-Brackmann (H-B) grades 3-4 5-6. Secondary included factors associated stratified...
Previous studies have reported that low levels of physical activity result in sarcopenic obesity (SO). However, the effects specific intensities on SO and optimal amount for lowering prevalence not been well studied. This study aimed to identify intensity related a lower SO. cross-sectional used data from nationwide Korean Frailty Aging Cohort Study (KFACS), which included 2071 older adults (1030 men, 1041 women). was defined according criteria European Society Clinical Nutrition Metabolism...
Abstract It has been suggested that taurine chloramine (TauCl) plays an important role in the downregulation of proinflammatory mediators. However, little is known about its effect on expression matrix metalloproteinases (MMPs). In this study, we investigated effects TauCl synovial MMPs. The MMP IL-1β stimulated fibroblast-like synoviocytes (FLSs) were studied using following techniques. Real-time PCR and semi-quantitative employed to analyze mRNA ELISA was used determine protein levels...
Taheebo, the purple inner bark of Bignoniaceae tree Tabebuia avellanedae Lorentz ex Griseb, which is found in tropical rain forests northeastern Brazil, has been used as a traditional medicine for various diseases more than 1,500 years. In current study, animal models were to demonstrate analgesic and anti-inflammatory properties its ethanolic extract, thereby investigating potential therapeutic treatment with pain inflammation. hot plate writhing tests vivo effect test 200 mg/kg dose...