A5041716011- Metabolism, Diabetes, and Cancer
- Endoplasmic Reticulum Stress and Disease
- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
- Cancer, Hypoxia, and Metabolism
- Parasitic infections in humans and animals
- Adipose Tissue and Metabolism
- Parasites and Host Interactions
- Pancreatic function and diabetes
- Parasitic Infections and Diagnostics
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Calcium signaling and nucleotide metabolism
- Diet and metabolism studies
- PI3K/AKT/mTOR signaling in cancer
- Circadian rhythm and melatonin
- Hepatitis C virus research
- Heat shock proteins research
- Hepatitis B Virus Studies
- Sirtuins and Resveratrol in Medicine
- Protein Kinase Regulation and GTPase Signaling
- Peroxisome Proliferator-Activated Receptors
- Toxin Mechanisms and Immunotoxins
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
Kyung Hee University
2016-2025
Asan Medical Center
2024
University of Ulsan
2024
Ulsan College
2024
Kyung Hee University Medical Center
2014-2017
Samsung Medical Center
2015
Hospital Universitario de Gran Canaria Doctor Negrín
2015
Hospital Universitario Insular de Gran Canaria
2015
Bio-Medical Science (South Korea)
2008-2012
University of Illinois Urbana-Champaign
2010
The heat shock response is an evolutionarily conserved mechanism that protects cells or organisms from the harmful effects of various stressors such as heat, chemicals toxins, UV radiation, and oxidizing agents. triggers expression a specific set genes proteins known genes/proteins molecular chaperones, including HSP100, HSP90, HSP70, HSP60, small HSPs. Heat (HSPs) play crucial role in thermotolerance aiding protecting insults stressors. HSPs are involved essential cellular functions protein...
Molecular chaperones are highly conserved across evolution and play a crucial role in preserving protein homeostasis. The 60 kDa heat shock (HSP60), also referred to as chaperonin (Cpn60), resides within mitochondria is involved maintaining the organelle’s proteome integrity HSP60 family, encompassing Cpn60, plays diverse roles cellular processes, including folding, cell signaling, managing high-temperature stress. In prokaryotes, well understood GroEL/GroES complex, which forms double-ring...
AMP-activated protein kinase (AMPK) functions as an energy sensor to provide metabolic adaptations under the ATP-deprived conditions such hypoxia. In present study, we considered a role of AMPK in adaptive response hypoxia by examining whether is involved regulation hypoxia-inducible factor-1 (HIF-1), heterodimeric transcription factor that critical for hypoxic induction physiologically important genes. We demonstrate or CoCl2 rapidly activated DU145 human prostate cancer cells, and its...
Hypoxia-inducible factor (HIF-1) plays a central role in the cellular adaptive response to hypoxic conditions, which are closely related pathophysiological such as cancer. Although reactive oxygen species (ROS) have been implicated regulation of and non-hypoxic induction HIF-1 under various ROS is quite controversial, mechanism underlying by not completely understood yet. Here, we investigated biochemical for ROS-induced revealing novel adenosine monophosphate-activated protein kinase (AMPK)...
Numerous physiological functions are controlled by redox‐responsive signaling pathways. Disruption of redox balance oxidative stress is recognized as a major cause many pathological conditions, including aging, highlighting the importance investigating how antioxidants maintain homeostasis. AMP ‐activated protein kinase ( AMPK ) activated in response to cellular conditions that accompany energy depletion and plays central role regulation homeostasis, tumorigenesis longevity. Recently,...
Ketone bodies (KBs), such as acetoacetate and β-hydroxybutyrate, serve crucial alternative energy sources during glucose deficiency. KBs, generated through ketogenesis in the liver, are metabolized into acetyl-CoA extrahepatic tissues, entering tricarboxylic acid cycle electron transport chain for ATP production. Reduced metabolism mitochondrial dysfunction correlate with increased neuronal death brain damage cerebral ischemia neurodegeneration. Both KBs ketogenic diet (KD) demonstrate...
Abstract: The prevalence of diabetes has exponentially increased in recent decades due to environmental factors such as nocturnal lifestyle and aging, both which influence the amount melatonin produced pineal gland. present study investigated effect on signaling pathways glucose transport C 2 12 mouse skeletal muscle cells. Intriguingly, treatment cells with (1 n m ) stimulated uptake twofold increase. Melatonin‐stimulated was inhibited co‐treatment receptor antagonist luzindole....
Baicalein is one of the major flavonoids in Scutellaria baicalensis Georgi and possesses various effects, including cytoprotection anti-inflammation. Because endoplasmic reticulum (ER) stress has been implicated neurodegenerative diseases, such as Alzheimer's disease, Parkinson's cerebral ischemia, we investigated effects baicalein on apoptotic death HT22 mouse hippocampal neuronal cells induced by thapsigargin (TG) brefeldin A (BFA), two representative ER inducers. Apoptosis, reactive...
Prolonged accumulation of misfolded proteins in the endoplasmic reticulum (ER) results ER stress-mediated apoptosis. Cyclophilins are protein chaperones that accelerate rate folding through their peptidyl-prolyl cis-trans isomerase (PPIase) activity. In this study, we demonstrated stress activates expression ER-localized cyclophilin B (CypB) gene a novel response element. Overexpression wild-type CypB attenuated stress-induced cell death, whereas overexpression an activity-defective mutant,...
Epidemiological evidence suggests a lower incidence of prostate cancer in Asian countries, where soy products are more frequently consumed than Western indicating that isoflavones from have chemopreventive activities cells. Here, we tested the effects isoflavone genistein on antioxidant enzymes DU145 Genistein significantly decreased reactive oxygen species levels and induced expression manganese (Mn) superoxide dismutase (SOD) catalase, which were associated with AMP-activated protein...
The sustained expansion of a tumor mass requires new blood vessel formation to provide rapidly proliferating cells with an adequate supply oxygen and nutrients. Hypoxia-inducible factor-1 (HIF-1) plays essential role in angiogenesis growth by regulating the transcription genes response hypoxic stress. This study was designed investigate effects melatonin on angiogenesis, as well mechanism underlying antitumor activities melatonin. In this study, we show that administration inhibits blocks...