The sustained expansion of a tumor mass requires new blood vessel formation to provide rapidly proliferating cells with an adequate supply oxygen and nutrients. Hypoxia-inducible factor-1 (HIF-1) plays essential role in angiogenesis growth by regulating the transcription genes response hypoxic stress. This study was designed investigate effects melatonin on angiogenesis, as well mechanism underlying antitumor activities melatonin. In this study, we show that administration inhibits blocks...

p ‐Coumaric acid, a hydroxy derivative of cinnamic has been known to possess antioxidant and anticancer activities. Despite its potential contribution chemopreventive effects, the mechanism by which ‐coumaric acid exerts antiangiogenic actions remains elusive. In this study, we revealed that inhibited sprouting endothelial cells in rat aortic rings tube formation migration cells. We observed could downregulate mRNA expression levels key angiogenic factors vascular growth factor basic...

Glycyrrhizic acid (GA) is the bioactive compound of licorice and has been used as a herbal medicine because its anti‐viral, anti‐cancer, anti‐inflammatory properties. This study was designed to investigate effects GA on tumor growth, angiogenesis, mechanisms underlying anti‐angiogenic activities GA. We observed that inhibited growth angiogenesis in mice. decreased angiogenic activities, such migration, invasion, tube formation endothelial cells. also demonstrated reduced production reactive...

Cinnamic aldehyde (CA), a key flavor compound in cinnamon essential oil, has been identified as an anti-oxidant, anti-angiogenic, and anti-inflammatory material. Recently, the neuroprotective effects of CA have reported various neurodegenerative disorders, including Parkinson’s disease (PD). In neurons, autophagy is tightly regulated, consequently, dysregulation may induce disorders. present study, we found that selective dopaminergic neuronal death substantia nigra...

Abstract Although peripheral artery disease (PAD) is a major health problem, there have been limited advances in medical therapies. In PAD patients, angiogenesis regarded as promising therapeutic strategy to promote new arterial vessels and improve perfusion of ischemic tissue. Autophagy plays critical role catabolic processes for cell survival under normal stressful conditions fundamental biological roles various cellular functions. the present study, we showed that autophagy endothelial...

Cancer cells undergo uncontrolled proliferation resulting from aberrant activity of various cell-cycle proteins. Therefore, despite recent advances in intensive chemotherapy, it is difficult to cure cancer completely. Recently, regulators became attractive targets therapy. Zingerone, a phenolic compound isolated ginger, nontoxic and inexpensive with varied pharmacological activities. In this study, the therapeutic effect zingerone as an anti-mitotic agent human neuroblastoma was...

Angiogenesis is an essential step for tumor survival and progression, the inhibition of angiogenesis a good strategy therapeutics. In this study, we investigated therapeutic effect zingerone in mouse model. Zingerone suppressed progression angiogenesis. Moreover, found that inhibited angiogenic activities endothelial cells by both direct indirect means. A mechanistic study showed MMP-2 MMP-9 were decreased treatment with zingerone. Interestingly, zingerone-mediated was involved JNK pathway....

Abstract Cells under hypoxic stress either activate an adaptive response or undergo cell death. Although some mechanisms have been reported, the exact mechanism behind death remains unclear. Recently, increased expression of fatty acid synthase (FASN) has observed in various human cancers. In highly proliferating cells, tumor‐associated FASN is considered necessary for both membrane lipids production and post‐translational protein modification, but are not fully understood. Further,...

Non-thermal atmospheric-pressure plasma has been introduced in various applications such as sterilization, wound healing, blood coagulation, and other biomedical applications.The most attractive application of non-thermal is cancer treatment, where the used to produce reactive oxygen species (ROS) facilitate cell apoptosis.We investigate effects different durations exposure dielectric-barrier discharge (DBD) on colon cells using measurement viability ROS levels, western blot,...

Kelch-like ECH-associated protein 1 (KEAP1)-nuclear factor erythroid-2-related 2 (NRF2) pathway is a major regulator protecting cells from oxidative and metabolic stress. Studies have revealed that this involved in mediating resistance to cytotoxic chemotherapy immunotherapy, however, its implications oncogene-addicted tumors are largely unknown. This study aimed elucidate whether could be potential therapeutic target for epidermal growth receptor (EGFR)-mutant non-small cell lung cancer.

Coenzyme Q10 (CoQ10) is an essential factor of the mitochondrial respiratory chain and has effective antioxidant properties. Therefore, CoQ10 been used in a variety clinical applications as nutritional supplement to treat several human diseases. Here, we tested effects on angiogenesis stimulated by basic fibroblast growth (bFGF). significantly inhibited bFGF-induced mouse Matrigel plug sprouting endothelial cells rat aortic rings. In addition, decreased ability tube formation, migration,...

While progressive dopaminergic neurodegeneration is responsible for the cardinal motor defects in Parkinson's disease (PD), new diagnostics and therapeutic targets are necessary to effectively address this major global health burden. We evaluated whether adhesion G protein-coupled receptor B1 (ADGRB1, formerly BAI1, brain-specific angiogenesis inhibitor 1) might contribute neuronal loss. used bioinformatic analyses, as well vitro vivo PD models. report study that ADGRB1 decreased level...

Parkinson's disease (PD) is characterized by a progressive and selective loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) striatum. 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) used to produce an animal model for PD, it converted 1‐methyl‐4‐phenylpyridine (MPP + ) animals. MPP accumulation leads neuronal cell death. Vesicular monoamine transporter 2 (VMAT2) regulates neurotransmitters into synaptic vesicles involved neuroprotection against neurotoxin‐induced...

Corticotropin releasing factor (CRF) is known to be involved in the stress response and some degenerative brain disorders. In addition, CRF has a role as neuromodulator adult cerebellar circuits. Data from developmental studies suggest putative for trophic during development. this study, we investigated family of peptides by culturing neurons presence CRF, urocortin or II. Primary cell cultures cerebella embryonic day 18 mice were established, cells treated either 1, 5 9 days with Basal...

Hypoxia-inducible factors (HIFs) are key regulators of hypoxic responses, and their stability transcriptional activity controlled by several kinases. However, the regulation HIF protein phosphatases has not been thoroughly investigated. Here, we found that overexpression Mg2+/Mn2+-dependent phosphatase 1 gamma (PPM1G), one Ser/Thr phosphatases, downregulated expression ectopic HIF-1α under normoxic or acute conditions. In addition, deficiency PPM1G upregulated endogenous oxidative stress...

Epidermal growth factor receptor (EGFR)‑tyrosine kinase inhibitors (TKIs) have been used to treat patients with non‑small cell lung cancer (NSCLC) and activating EGFR mutations; however, the emergence of secondary mutations in or acquisition resistance EGFR‑TKIs can develop is involved clinical failure. Since angiogenesis associated tumor progression blockade antitumor drugs, inhibition could be a rational strategy for developing anticancer drugs combined NSCLC. The signaling pathway...