A5032383727- Microtubule and mitosis dynamics
- Neuroblastoma Research and Treatments
- Cancer-related Molecular Pathways
- Mitochondrial Function and Pathology
- Air Quality and Health Impacts
- Cellular transport and secretion
- Cell death mechanisms and regulation
- Retinal Development and Disorders
- DNA Repair Mechanisms
- Biological and pharmacological studies of plants
- Glioma Diagnosis and Treatment
- Genetic and Kidney Cyst Diseases
- Cancer, Hypoxia, and Metabolism
- Ginger and Zingiberaceae research
- Heat shock proteins research
- Opportunistic and Delay-Tolerant Networks
- High Altitude and Hypoxia
Kyung Hee University
2018-2023
CCAR2 (cell cycle and apoptosis regulator 2) controls a variety of cellular functions; however, its main function is to regulate cell survival death in response genotoxic metabolic stresses. Recently, we reported that protects cells from following mitochondrial stress, possibly by co-operating with Hsp60. However, it not clear how Hsp60 control death. Here, found depleting downregulated expression survivin, member the inhibitor (IAP) family. Survivin neuroblastoma tissues human cancer lines...
Cancer cells undergo uncontrolled proliferation resulting from aberrant activity of various cell-cycle proteins. Therefore, despite recent advances in intensive chemotherapy, it is difficult to cure cancer completely. Recently, regulators became attractive targets therapy. Zingerone, a phenolic compound isolated ginger, nontoxic and inexpensive with varied pharmacological activities. In this study, the therapeutic effect zingerone as an anti-mitotic agent human neuroblastoma was...
SIRT2, a member of the Class III HDAC family, participates in diverse cellular processes and regulates several pathological conditions. Although few reports show that SIRT2 cell cycle, causes outcomes SIRT2-dependent proliferation remain unclear. Here, we examined effects suppression human RPE1 cells using siRNA targeting AK-1, SIRT2-specific inhibitor. The number primary cilia SIRT2-suppressed increased under serum-present Suppressing induced cycle arrest at G0/G1 phase by inactivating...
The Aurora kinase family of serine/threonine protein kinases comprises A, B, and C plays an important role in mitotic progression. Several inhibitors have been developed as anti-cancer therapeutics. Here, we examined the effects a pan-Aurora inhibitor, AMG900, against glioblastoma cells. AMG900 inhibited proliferation A172, U-87MG, U-118MG cells by upregulating p53 p21 subsequently inducing cell cycle arrest senescence. Abnormal progression was triggered dysregulated mitosis. Mitosis...
Particulate matter (PM), a major component of outdoor air pollution, damages DNA and increases the risk cancer. Although harmful effects PM at genomic level are known, detailed mechanism by which affects chromosomal stability remains unclear. In this study, we investigated novel on mitotic progression identified underlying mechanisms. Gene set enrichment analysis lung cancer patients residing in countries with high concentrations revealed downregulation genes associated mitosis structures....
Hypoxia-inducible factors (HIFs) are key regulators of hypoxic responses, and their stability transcriptional activity controlled by several kinases. However, the regulation HIF protein phosphatases has not been thoroughly investigated. Here, we found that overexpression Mg2+/Mn2+-dependent phosphatase 1 gamma (PPM1G), one Ser/Thr phosphatases, downregulated expression ectopic HIF-1α under normoxic or acute conditions. In addition, deficiency PPM1G upregulated endogenous oxidative stress...
CCAR2 (cell cycle and apoptosis regulator 2) is a multifaceted protein involved in cell survival death following cytotoxic stress. However, little known about the physiological functions of regulating proliferation absence external stimuli. The present study shows that CCAR2-deficient cells possess multilobulated nuclei, suggesting defect division. In particular, duration mitotic phase was perturbed. This disturbance progression resulted from premature loss cohesion with centromere,...
Abstract Particulate matter (PM), a major component of outdoor air pollution triggers genotoxicity as well cytotoxicity. Although the harmful effects PM on DNA damage and its carcinogenic risk have been thoroughly studied, detailed mechanism by which affects chromosomal stability remains unclear. Maintenance chromosome is finely monitored during mitotic phase through multiple proteins structures. The present study shows that treatment urban particulate (UPM) inhibited proliferation lung...