A5019490864- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Inflammatory mediators and NSAID effects
- Cancer Mechanisms and Therapy
- Invertebrate Immune Response Mechanisms
- Marine Sponges and Natural Products
- Fungal and yeast genetics research
- Aquaculture disease management and microbiota
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Neurobiology and Insect Physiology Research
- Adipokines, Inflammation, and Metabolic Diseases
- Immune Response and Inflammation
- Mitochondrial Function and Pathology
- Hepatitis B Virus Studies
- Synthesis and Biological Activity
- Pharmacogenetics and Drug Metabolism
- Bacterial Genetics and Biotechnology
- Drug Transport and Resistance Mechanisms
- Fermentation and Sensory Analysis
- Eicosanoids and Hypertension Pharmacology
- Protease and Inhibitor Mechanisms
- Proteoglycans and glycosaminoglycans research
Pusan National University
2012-2024
Korea Institute of Radiological and Medical Sciences
2019
Ajou University
2018
Gachon University
2018
Keimyung University
2018
Busan National University of Education
2015
Chungnam National University
1998-1999
The University of Texas at Austin
1997
Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion distances from the existing vascular supply increases, resulting in hypoxia cancer cells. Sustained expansion a mass requires new blood vessel formation to provide rapidly proliferating cells with adequate oxygen and nutrients. The key regulator hypoxia-induced angiogenesis transcription factor known as hypoxia-inducible (HIF)-1. HIF-1alpha stabilized by reactive species (ROS) enhances expression several...
BEM2 of Saccharomyces cerevisiae encodes a Rho-type GTPase-activating protein that is required for proper bud site selection at 26 degrees C and emergence elevated temperatures. We show here the temperature-sensitive growth phenotype bem2 mutant cells can be suppressed by increased dosage GIC1 gene. The Gic1 protein, together with its structural homolog Gic2, are cell size shape control, selection, emergence, actin cytoskeletal organization, mitotic spindle orientation/positioning, mating...
Adult stem cells are pivotal for maintaining tissue homeostasis, and their functional decline is linked to aging its associated diseases, influenced by the niche cellsâ environment. Age- cancer-related reduction of vitamin D receptor levels well documented in human clinical studies. However, mechanisms through which D/vitamin pathway contributes anti-aging extends life expectancy not understood. In this study, we aimed determine protective role differentiated enterocytes (ECs) during...
We investigated a molecular mechanism underlying quercetin-mediated amelioration of colonic mucosal injury and analyzed chemical structure contributing to the quercetin9s effect. Quercetin up-regulated vascular endothelial growth factor (VEGF), an ulcer healing factor, not only in colon epithelial cell lines but also inflamed tissue. VEGF derived from quercetin-treated cells promoted tube formation. The induction was dependent on hypoxia-inducible factor-1 (HIF-1) activation. delayed HIF-1α...
Mitochondrial dysfunction has been found to be associated with various pathological conditions, particularly cancer. However, the mechanisms underlying tumor malignancy induced by mitochondrial are not fully understood. In present study, effects of on epithelial-mesenchymal transition (EMT), were investigated using mitochondrial-depleted ρ0 cells derived from Hep3B hepatocarcinoma cell line. The Hep3B/ρ0 displayed EMT phenotype more aggressive migration and higher invasiveness compared their...
Abstract Thymosin β10 is a monomeric actin sequestering protein that regulates dynamics. Previously, we and others have shown thymosin acts as an actin-mediated tumor suppressor. In this study, show not only cytoskeletal regulator, but it also potent inhibitor of angiogenesis growth by its interaction with Ras. We found overexpressed significantly inhibited vascular endothelial factor–induced cell proliferation, migration, invasion, tube formation in vitro. Vessel sprouting was ex vivo....
Angiogenesis is defined as the formation of new blood vessels form existing surrounding a tumor. The process angiogenesis an important step for tumor growth and metastasis, inflammation. Thus, inhibitors that suppress inflammation have been studied anticancer treatment. Recently, many research groups investigated anti-angiogenic activity natural compounds since some demonstrated to properties. Among compounds, we focused on betaine, which known Betaine, trimethylglycine (TMG), was first...
Sodium tolerance in yeast is enhanced by continuous activation of calcineurin, a Ca<sup>2+</sup>/calmodulin-dependent protein phosphatase that required for modulation the Na<sup>+</sup>efflux mechanism. We isolated several salt-tolerant mutations with treatment ethylmethane sulfonate under high salt stress. One was mapped <i>PMR1</i>gene. Pmr1p, P-type Ca<sup>2+</sup>-ATPase Golgi apparatus, regulates cytosolic Ca<sup>2+</sup> level various responses. Cytosolic concentration <i>pmr1</i>...
The chemotherapeutic agent temozolomide (TMZ) and the anti-angiogenic thalidomide (THD) have both demonstrated anti-tumor activity in patients with recurrent malignant glioma. Combination treatment TMZ THD glioblastoma multiforme (GBM) appears to be more effective than either drug alone. To investigate mechanism of this effect, we examined combined effects a rat glioma xenograft model. We found that combination markedly inhibited growth tumors were orthotopically implanted into brains. Using...
Thioredoxin (Trx), a small redox protein, is overexpressed in number of tumors, however, its roles tumor cells were not defined well. To investigate the effect Trx, we transfected Trx or antisense vectors into HT1080 cells. Trx-overexpressed induced migration endothelial through Flt-1 vascular growth factor (VEGF) receptor type-1. However, was reduced by overexpression antisense-Trx. understand relationship between and hypoxia-induced angiogenesis, observed expression level VEGF...
Glioblastomas are highly vascularized tumors and anti-angiogenic strategy is one of the most promising therapeutic approaches to treat brain tumors. Interferon α (IFN-α) as a single agent or combined with standard chemo-therapy has been shown inhibit various tumors, but effect combination therapy on not well studied. We determined optimal dose schedule pegylated IFN-α (PEG-IFN-α) against U-87MG human glioblastoma cells growing orthotopically in nude mice, since several clinical trials...
Hispidulin is a natural bioactive flavonoid that has been studied for its potential therapeutic properties, including anti-inflammatory, antioxidant, and neuroprotective effects. The aim of this study was to explore whether hispidulin could inhibit the endothelial inflammation triggered by Porphyromonas gingivalis (P. gingivalis) lipopolysaccharide (LPS). adhesion monocytes vascular endothelium evaluated through in vitro ex vivo monocyte assays. We analyzed migration across layer using...
A new piperazine derivative, SJ-8002, is a synthetic anti-cancer agent which exhibits microtubule-inhibiting activities. In this study, we investigated the possibility that compound inhibits angiogenesis and induces tumor-cell apoptosis using bovine aortic endothelial cells (BAECs) human hepatocellular carcinoma (HepG2) as model system, respectively. vivo, SJ-8002 decreased neovascularization of chick embryos basic fibroblast growth factor (bFGF)-induced in chorioallantoic membrane (CAM)...
Coenzyme Q10 (CoQ10) is an essential factor of the mitochondrial respiratory chain and has effective antioxidant properties. Therefore, CoQ10 been used in a variety clinical applications as nutritional supplement to treat several human diseases. Here, we tested effects on angiogenesis stimulated by basic fibroblast growth (bFGF). significantly inhibited bFGF-induced mouse Matrigel plug sprouting endothelial cells rat aortic rings. In addition, decreased ability tube formation, migration,...
Angiogenesis is an important process involved in tumor growth and metastasis. Many studies have investigated the use of natural compounds such as angiogenic inhibitors. Xylitol a 5-carbon sugar alcohol artificial sweetener that has been used chewing gums to prevent tooth decay. also known inhibit inflammatory cytokine expression induced by lipopolysaccharide (LPS). Since angiogenesis inflammation share common signaling pathway, we role xylitol angiogenesis. inhibited migration, invasion tube...
Age-related changes in tissue-resident adult stem cells may be closely linked to tissue aging and age-related diseases, such as cancer. β-Hydroxybutyrate is emerging an important molecule for exhibiting the anti-aging effects of caloric restriction fasting, which are generally considered beneficial cell maintenance regeneration. The β-hydroxybutyrate on remain largely unknown. Therefore, this study was undertaken investigate whether supplementation exerts intestinal that were derived from...