A5069103907- Radiopharmaceutical Chemistry and Applications
- Phytochemicals and Antioxidant Activities
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Peptidase Inhibition and Analysis
- Advanced biosensing and bioanalysis techniques
- Effects of Radiation Exposure
- Palliative Care and End-of-Life Issues
- Genomics, phytochemicals, and oxidative stress
- Toxin Mechanisms and Immunotoxins
- Biochemical effects in animals
- ATP Synthase and ATPases Research
- Click Chemistry and Applications
- Synthesis and biological activity
- Cell death mechanisms and regulation
- Advanced Biosensing Techniques and Applications
- Biochemical and Structural Characterization
- Synthesis of Organic Compounds
- Salivary Gland Disorders and Functions
- Patient Dignity and Privacy
- Marine Sponges and Natural Products
- Silkworms and Sericulture Research
- Phytochemical and Pharmacological Studies
- Bacteriophages and microbial interactions
- Hydrogen's biological and therapeutic effects
Columbia University
2023
New York University
2023
Osong Medical Innovation Foundation
2018-2020
Korea Atomic Energy Research Institute
2012-2019
Chungnam National University
2011-2012
Food and Nutrition Service
2007
Pusan National University
2003
The present study was designed to evaluate the radioprotective effect of hesperidin, a citrus flavanoglycone, against γ-radiation-induced cellular damage in liver, heart, and kidney rats. Whole-body γ-radiation exposure (5 Gy) healthy adult rats resulted oxidative stress manifested as increased levels serum marker enzymes, lipid peroxidation, fibrosis tissues, accompanied by depletion glutathione abnormal alteration lysosomal enzymes. Treatment with hesperidin (50 100 mg/kg, p.o.) for 7 days...
Palliative care improves the quality of life for seriously ill patients, but misconceptions and knowledge gaps hinder its implementation in home healthcare (HHC). This study developed pilot-tested HHC-specific questionnaires to measure palliative knowledge, attitudes, confidence (PC-KAC) among clinicians, caregivers. Using literature reviews, expert input, cognitive interviews, were refined ensure clarity, practical relevance, content validity. Pilot testing revealed widespread confusion...
Luteolin was gamma irradiated at doses of 0, 15, 30, 50, 70, and 100 kGy. We observed that the luteolin peak decreased simultaneously with appearance new radiolytic peaks, using high-performance liquid chromatography (HPLC). The highest (GLM) product in gamma-irradiated a dose 70 kGy, GLM identified by nuclear magnetic resonance high-performance-liquid-chromatography-quadrupole-time-of-flight (HPLC-Q-TOF) mass spectrometry. examined whether kGy has more effective anti-melanogenic effects...
With the high efficacy of protein-based therapeutics and plenty intracellular drug targets, cytosolic protein delivery in a cell-specific manner has attracted considerable attention field precision medicine. Herein, we present an system based on target-specific repebody translocation domain Pseudomonas aeruginosa exotoxin A. The platform was constructed by genetically fusing EGFR-specific as targeting moiety to domain, while cargo fused C-terminal end platform. revealed efficiently...
Abstract With a growing number of intracellular drug targets and the high efficacy protein therapeutics, targeted delivery active proteins with negligible toxicity is challenging issue in field precision medicine. Herein, programed assembly nucleoprotein nanoparticles (NNPs) using DNA zinc fingers (ZnFs) for presented. Two types ZnFs different sequence specificities are genetically fused to targeting moiety cargo, respectively. Double‐stranded multiple ZnF‐binding sequences grafted onto...
In this report, the novel and site-specific radioiodination of biomolecules by using aryl diamine alkyl aldehyde condensation reaction in presence a Cu2+ catalyst under ambient conditions was reported. 125I-labeled synthesized tin precursor with high radiochemical yield (72 ± 6%, n = 5) purity (>99%). The utility radioiodinated demonstrated through diamine-installed c[RGDfK(C)] peptide human serum albumin (HSA). Radioiodinated HSA protein were yields purity. 125I-HSA showed excellent vivo...
Radioisotope ADME (RI-ADME) studies are enabling visualization of the biodistribution in molecular imaging. We applied RI-ADME to investigate tumor targeting capacity and trastuzumab-monomethyl auristatin F (LCB14-0110) JIMT-1 xenograft mice healthy marmoset. The LCB14-0110 was labelled with 125I. 125I-LCB14-0110 intravenously administered animals. gamma-count single-photon emission computed tomography/computed tomography (SPECT/CT) conducted for biodistributioon bioimaging biopharmaceutics....
In article number 1802618, Joong-jae Lee, Hak-Sung Kim, and co-workers develop an intracellular protein delivery system by sequence specific DNA-protein interactions for targeted therapy. Engineered nucleoproteins are sequentially assembled onto the surface of gold nanoparticles. The resulting nucleoprotein nanoparticles exhibit highly programmable designability functional loading, remarkable growth retardation tumor cells with a negligible toxic effect.
본 연구는 BALB/c 마우스에서 감마선 조사 후 퀘르세틴을 7일 동안 경구 투여하여 조사로 인한 조혈계 및 간세포 손상에 대한 방사선 회복 효과를 검토하였다. 투여한 군은 조사군에 비해 비장 흉선 지수, 백혈구 수치가 증가하여 조혈 면역계 대해 보호 효과가 있음을 확인하였다. 또한 ALT와 AST의 활성도 유의적으로 감소하여 보호효과를 조사에 의해 체내에서 생성된 자유라디칼은 생체물질과 결합하여 지질과산화를 일으키고 산화적 스트레스를 유도하여 조직을 손상시킨다. 군의 지질과산화는 낮게 나타나 방사선에 의한 장애를 감소시켰으며, 항산화효소도 생체 내항산화 회복시켰다. 이상의 결과를 통해 조사후에 퀘르세틴의 투여는 있어 보호제로 유용하게 사용될 수 있다.
본 연구는 청소년의 문제행동 예방 정책을 수립하는데 기초자료를 제공하고자 하는 목적에서 학업스트레스와 갈등적 친구관계 및 심리적 불안감과 문제행동의 구조적 관계가 어떠한지 실증적으로 분석하고자 하였다. 연구에서는 한국아동청소년 데이터 아카이브의 NYPI 횡단조사를 통한 자료로써 '청소년 저연령화 실태와 정책 과제 연구'의 주제로 수집된 자료를 사용하였다. 자료는 전국의 초등학교 재학생 4학년∼6학년과 중학교 1학년∼3학년 학생을 대상으로 지역과 중학교의 학교유형, 학생 학교 수를 반영한 변형비례배분방식의 층화다단계집락표집 방식을 사용해 초등학생 2,989명, 중학생 3,053명으로 총 6,042명을 연구대상자로 최종 선정하였다. 자료분석 프로그램은 SPSS 21.0과 AMOS 21.0을 통하여 분석을 실시하였으며, 연구의 주요 검증결과에 대한 함의를 요약하면 다음과 같다. 첫째, 주요변인인 학업스트레스, 친구관계, 간 관계에서 불안감이 매개 역할을 것으로 나타났다. 둘째,...