A5064866127- Angiogenesis and VEGF in Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Neuropeptides and Animal Physiology
- Oral microbiology and periodontitis research
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Bone Metabolism and Diseases
- Dental Erosion and Treatment
- Dental materials and restorations
- Lipid Membrane Structure and Behavior
- Curcumin's Biomedical Applications
- Cytokine Signaling Pathways and Interactions
- Neuroscience and Neuropharmacology Research
- Bone and Dental Protein Studies
- Protease and Inhibitor Mechanisms
- Endodontics and Root Canal Treatments
- Chemokine receptors and signaling
- Proteoglycans and glycosaminoglycans research
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Adipose Tissue and Metabolism
- Biomarkers in Disease Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
Pusan National University
2015-2024
The University of Tokyo
2024
Pusan National University Yangsan Hospital
2011-2013
Seoul National University
2005
Visfatin has been originally identified as a growth factor for early stage B cells and recently known an adipokine. Here, we report that hypoxia induces the visfatin mRNA protein levels in MCF7 breast cancer cells. We also demonstrate induction of gene is regulated by hypoxia‐inducible factor‐1α (HIF‐1α). Moreover, 5′‐flanking promoter region human contains two functional HIF responsive elements (HREs), activating expression visfatin. Mutation these HREs abrogates activation luciferase...
// Hyun-Joo Park 1 , Su-Ryun Kim Su Seong Hee-Jun Wee 2 Moon-Kyoung Bae 3 Mi Heon Ryu 4 and Soo-Kyung Department of Dental Pharmacology, School Dentistry, Pusan National University, Yangsan, South Korea Biochemistry, College Pharmacy, Seoul Seoul, Oral Physiology, Pathology, Correspondence: Bae, email: Keywords : Visfain; Notch1; NF- κB; breast cancer cells Received May 9, 2014 Accepted June Published 10, Abstract Overexpression Notch1 has been associated with cancer. We recently showed that...
In vertebrates, melatonin is primarily secreted from the pineal gland but it affects various biological processes including sleep-wake cycle, vasomotor control, immune system and bone homeostasis. Melatonin has been known to promote osteoblast differentiation maturation, a direct role of on osteoclast still elusive. The present study investigated effect macrophages osteoclasts. presence significantly reduced receptor activator nuclear factor κB ligand (RANKL)-induced osteoclastogenesis...
Insulin-like growth factor II (IGF-II), highly expressed in a number of human tumours, has been recently known to promote neovascularization vivo. Yet, the detailed mechanism by which IGF-II induces angiogenesis not well defined. In present study, we explored an angiogenic activity vitro model. Human umbilical vein endothelial cells (HUVECs) treated with rapidly aligned and formed capillary-like network on Matrigel. chemotaxis assay, remarkably increased migration HUVECs. A rapid transient...
Obesity is frequently associated with breast cancer. Such associations are possibly mediated by adipokines. Visfatin, an adipokine, has recently been shown to be related the development and progression of Therefore, down-regulation visfatin may a novel strategy for cancer therapy. Curcumin anticancer activities modulating multiple signaling pathways genes. The purpose this study was investigate whether gene expression affected curcumin in human cells characterize functional role We found...
Bisphosphonates are one of the most widely used synthetic pyrophosphate analogues for treatment bone resorbing diseases such as osteoporosis, multiple myeloma, and metastases. Although therapeutic usefulness bisphosphonates mainly depends on their anti-osteoclastogenic effect, a severe side-effect called bisphosphonate-related osteonecrosis jaw (BRONJ) could not be explained by effect bisphosphonates. In present study, we have evaluated changes in osteoclastogenesis- or...
The purpose of this study was to investigate the effects mesoporous bioactive glass nanoparticle (MBN)/graphene oxide (GO) composites on mineralization ability and differentiation potential human dental pulp stem cells (hDPSCs). MBN/GO were synthesized using sol-gel method colloidal processing enhance bioactivity mechanical properties MBN. Characterization FESEM, XRD, FTIR, Raman spectrometry showed that successfully synthesized. hDPSCs then cultured directly (40:1 20:1) in vitro. promoted...
Dentin hypersensitivity (DH) is one of the most common clinical conditions usually associated with exposed dentinal surfaces. In this study, we identified effectiveness poly(amidoamine) (PAMAM) dendrimer-coated mesoporous bioactive glass nanoparticles (MBN) (PAMAM@MBN) on DH treatment, examining ion-releasing effect, dentin remineralization, and occluding effect tubules. We synthesized MBN PAMAM@MBN. After soaking each sample in simulated body fluid (SBF), observed effects remineralization...
Cathepsin K (CTSK) is a cysteine protease that mainly produced from mature osteoclasts and contributes to the destruction of connective tissues mineralized matrix as consequence periodontal disease (PD). However, few studies have reported its regulatory role in osteoclastogenesis-supporting cells inflammatory conditions. Here, we investigated CTSK cells, focusing on modulation paracrine function. Microarray data showed was upregulated PD patients compared with healthy individuals, which...
Connective tissue growth factor (CTGF), an extracellular matrix protein with various biological functions, is known to be upregulated in multiple chronic diseases such as liver fibrosis and congestive heart failure, but the mechanism it undertakes cause alveolar bone loss periodontitis remains elusive.The present study therefore investigates pathways involving CTGF periodontitis.RNA sequencing revealed a notable increase expression of tissues.Also, TRAP staining, activity resorption assays...
Abstract The von Hippel-Lindau protein (pVHL) is a major tumor suppressor and also associated with the inhibition of angiogenesis via HIF-1α ubiquitination proteasomal degradation. To further elucidate biological activity pVHL in angiogenesis, pVHL-interacting proteins were screened using yeast two-hybrid system. We found that mouse homologue long form Drosophila l(2)tid, Tid-1L, directly interacts vitro vivo. Furthermore, Tid-1L protein; enhanced interaction between pVHL, leading to...