Angiogenesis is an important mediator of tumor progression. As tumors expand, diffusion distances from the existing vascular supply increases, resulting in hypoxia cancer cells. Sustained expansion a mass requires new blood vessel formation to provide rapidly proliferating cells with adequate oxygen and nutrients. The key regulator hypoxia-induced angiogenesis transcription factor known as hypoxia-inducible (HIF)-1. HIF-1alpha stabilized by reactive species (ROS) enhances expression several...

Matrix metalloproteinase-9 (MMP-9) plays an important role in the invasion and metastasis of cancer cells. The synthesis secretion MMP-9 can be stimulated by a variety stimuli, including cytokines phorbol 12-myristate 13-acetate (PMA), during various pathological processes, such as tumor invasion, atherosclerosis, inflammation, rheumatoid arthritis, whereas MMP-2 is usually expressed constitutively. Delphinidin, anthocyanidin present pigmented fruits vegetables, possesses potent antioxidant,...

Abstract The concept of drug repositioning has recently received considerable attention in the field oncology. In present study, we propose that paroxetine can be used as a potent anticancer drug. Paroxetine, one selective serotonin reuptake inhibitors (SSRIs), been widely prescribed for treatment depression and anxiety disorders. Recently, SSRIs have reported to activity various types cancer cells; however, underlying mechanisms their action are not yet known. this investigated potential...

Mitochondrial dysfunction has been found to be associated with various pathological conditions, particularly cancer. However, the mechanisms underlying tumor malignancy induced by mitochondrial are not fully understood. In present study, effects of on epithelial-mesenchymal transition (EMT), were investigated using mitochondrial-depleted ρ0 cells derived from Hep3B hepatocarcinoma cell line. The Hep3B/ρ0 displayed EMT phenotype more aggressive migration and higher invasiveness compared their...

Abstract Statins are a class of lipid‐lowering drugs that have recently been used in drug repositioning the treatment human cancer. However, underlying mechanism statin‐induced cancer cell death has not clearly defined. In present study, we evaluated anticancer effect pitavastatin on oral squamous carcinoma (OSCC), SCC15 and SCC4 cells found FOXO3a might be direct target pitavastatin‐induced death. Our data revealed selectively suppressed viability induced intrinsic apoptosis...

Methamphetamine (MA) is a highly addictive central nervous system stimulant. Drug addiction not static condition but rather chronically relapsing disorder. Hair valuable and stable specimen for chronic toxicological monitoring as it retains toxicants metabolites. The primary focus of this study was to discover the metabolic effects encompassing diverse pathological symptoms MA addiction. Therefore, alterations were investigated in human hair following heavy abuse using both targeted...

Backgrounds Freezing of gait (FoG) is a common and debilitating symptom Parkinson's disease (PD) that can lead to falls reduced quality life. Wearable sensors have been used detect FoG, but current methods limitations in accuracy practicality. In this paper, we aimed develop deep learning model using pressure sensor data from wearable insoles accurately FoG PD patients. Methods We recruited 14 patients collected multiple trials standardized walking test the Pedar insole system. proposed...

Persistent neurochemical disturbances by repeating drug reward and withdrawal lead to addiction. Particularly, withdrawal, usually starting within hours of the last dose, is considered as a critical step in transition addiction treatment clue. The aim this study was uncover metabolic effects associated with methamphetamine (MA) short-term abstinence using both non-targeted targeted metabolomics. Metabolic alterations were investigated rat plasma collected immediately after 16 days MA...

Molecular and metabolic alterations in cancer cells are one of the leading causes acquired resistance to chemotherapeutics. In this study, we explored an experimental strategy identify which these can induce erlotinib human pancreatic cancer. Using genetically matched erlotinib-sensitive (BxPC-3) erlotinib-resistant (BxPC-3ER) cells, conducted a multi-omics analysis metabolomes transcriptomes cells. Untargeted targeted metabolomic analyses revealed significant changes pathways involved...

Although epidermal growth factor receptor‐tyrosine kinase inhibitors ( EGFR ‐ TKI s) have been introduced for the treatment of non‐small cell lung cancer NSCLC ), emergence secondary T790M mutation in or amplification Met proto‐oncogene restrain clinical success s. Since heat shock protein‐90 (Hsp90) stabilizes various oncoproteins including and c‐Met, inhibition Hsp90 activity appears as a rational strategy to develop anticancer drugs. Despite preclinical efficacy geldanamycin‐anasamycin GA...

The current method for diagnosing methamphetamine use disorder (MUD) relies on self-reports and interviews with psychiatrists, which lack scientific rigor. This highlights the need novel biomarkers to accurately diagnose MUD. In this study, we identified transcriptome using hair follicles proposed a diagnostic model monitoring MUD treatment process. We performed RNA sequencing analysis follicle cells from healthy controls former patients who had been detained in past illegal of (MA)....

One of the most prominent hallmarks cancer cells is their dependency on glycolytic pathway for energy production. As a potent inhibitor glycolysis, 2-deoxy-d-glucose (2DG) has been proposed treatment and extensively investigated in clinical studies. Moreover, 2DG reported to interfere with other biological processes including glycosylation. To further understand overall effect metabolic alteration by 2DG, we performed biochemical metabolomics analyses oral squamous cell carcinoma lines. In...

Pancreatic cancer is one of the most lethal types cancer, due to difficulty in early detection and limited efficacy available treatments. Erlotinib used inhibit epidermal growth factor receptor for treatment pancreatic cancer; however, erlotinib resistance a major issue mechanisms underlying development remain unclear. To better understand alterations tumor metabolism by acquired erlotinib, an erlotinib‑resistant cell line (HPAC‑ER) was established, followed comparison metabolic...

The effective cure for oral squamous cell carcinoma (OSCC) patients is challenging due late diagnosis and fatal metastasis. standard OSCC often depends on the subjective interpretation of conventional histopathology. Additionally, there no way prognosis. Over past decade, nano-mechanical stiffness has been considered as a quantitative measure cancer diagnosis. Nevertheless, its application to prognosis still in primitive stage. In this study, we investigated whether progression can be...