A5079204773- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Diverse Approaches in Healthcare and Education Studies
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Stress Responses and Cortisol
- Food Quality and Safety Studies
- Neuroscience and Neuropharmacology Research
- Education and Learning Interventions
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Mitochondrial Function and Pathology
- Glycosylation and Glycoproteins Research
- Angiogenesis and VEGF in Cancer
- Agriculture, Soil, Plant Science
- Sarcoma Diagnosis and Treatment
- Nutrition, Health and Food Behavior
- Histone Deacetylase Inhibitors Research
- Cellular Mechanics and Interactions
- Sports Performance and Training
- Health and Wellbeing Research
- RNA modifications and cancer
- Advanced Polymer Synthesis and Characterization
- S100 Proteins and Annexins
Sungkyunkwan University
2016-2024
Samsung Medical Center
2016-2024
Boditech Med (South Korea)
2024
Duksung Women's University
2023
Samsung (South Korea)
2017-2022
Kyung Hee University
2010-2018
Seoul National University
2003-2018
Korea Basic Science Institute
2008-2017
Pohang University of Science and Technology
2003-2015
National Academy of Agricultural Science
2013
Abstract Serum amyloid A (SAA) is a major acute-phase reactant, and has been demonstrated to mediate proinflammatory cellular responses. Although SAA used as an indicator for variety of inflammatory diseases, the role in synovial hyperplasia proliferation endothelial cells, pathological hallmark rheumatoid arthritis (RA), yet be elucidated. In this study, we have that promotes human fibroblast-like synoviocytes (FLS). addition, protects RA FLS against apoptotic death induced by serum...
Abstract Most anaplastic lymphoma kinase ( ALK )‐rearranged non‐small cell lung cancers (NSCLCs) show good clinical response to inhibitors. However, some ‐rearranged NSCLC patients various primary responses with unknown reasons. Previous studies focused on the aspects of fusions in small cohorts, or were conducted vitro and/or vivo investigate function ALK. One suggested theories describes how echinoderm microtubule‐associated protein‐like 4 EML4 ) –ALK variants play a role towards different...
Solitary fibrous tumors (SFTs) are NAB2-STAT6 fusion-associated neoplasms. There several subtypes of fusions, but their clinical significances still unclear. Moreover, the mechanisms malignant progression also poorly understood. In this study, using 91 SFT cases, we examined whether fusion variants associated with clinicopathological parameters and investigated molecular mechanism transformation whole-exome sequencing. We detected variant 1b (NAB2ex4-STAT6ex2) in 51/91 (56%) cases 2a/2b...
In response to the recent economic crisis in Korea and its negative effects on families, current study examined interrelationships among pressure, emotional distress, marital conflict, satisfaction for 236 Korean couples. The family stress model ( Conger & Elder, 1994 ; Conger, Rueter, 2000 1999 ) was tested using structural equation modeling. results generally supported theoretical model, showing that pressure negatively affects via distress conflict. also implied cultural differences...
Tumor metastasis involves circulating and tumor‐initiating capacities of metastatic cancer cells. Epithelial‐mesenchymal transition (EMT) is related to self‐renewal capacity tumor cell (CTC) characteristics for metastasis. Although a life‐threatening, complicated process that occurs through circulation cells, mechanistic aspects have been largely unknown. Hepatic transmembrane 4 L six family member 5 (TM4SF5) promotes EMT malignant growth migration, so it was rationalized TM4SF5, as...
The maintenance of endothelial integrity is important for prevention vascular diseases. Several growth factors, such as bFGF and angiopoietin-1, have been shown to suppress cell apoptosis thus help maintain integrity. studies suggested that receptor activator NF-kappaB (RANK) its ligand (RANKL) could be involved in physiology. Using immunofluorescence reverse transcriptase-polymerse chain reaction, we found RANK was expressed by cells, RANKL arterial smooth muscle cells. Furthermore,...
Summary Transmembrane 4 L six family member 5 (TM4SF5) plays an important role in cell migration, and focal adhesion kinase (FAK) activity is essential for homeostatic pathological migration of adherent cells. However, it unclear how TM4SF5 signaling mediates the activation cellular machinery, FAK activated during adhesion. Here, we showed that direct adhesion-dependent binding to causes a structural alteration may release inhibitory intramolecular interaction FAK. In turn, this activate at...
To clarify the role of vascular NAD(P)H oxidase in pathogenesis cerebral vasospasm after subarachnoid hemorrhage (SAH), both activity and/or activation mechanisms vasculature and effect inhibition on SAH-induced were assessed.The changes luminal perimeter middle artery measured histologically SAH was induced according to a 2-hemorrhage model rats. The with lucigenin assay at different time intervals from 12 hours 14 days injection autologous blood into cisterna magna. membrane translocation...
Activation of EGF receptors is closely involved in vascular proliferative diseases. The signaling mechanisms ligands, including betacellulin (BTC) and amphiregulin (AR), are poorly understood. We examined how BTC AR induced DNA synthesis activity primary cultures human thoracic aortic smooth muscle cells (HTASMCs). phosphorylation all four present on HTASMCs: ErbB1, ErbB2, ErbB3, ErbB4. rapidly the Akt, GSK3α/β, two FoxO factors, FKHR AFX, a dose- time-dependent manner. increased nuclear...
Abstract Rheumatoid arthritis (RA) synoviocytes are resistant to apoptosis and exhibit a transformed phenotype, which might be caused by chronic exposure genotoxic stimuli including reactive oxygen species growth factors. In this study, we investigated the role of vascular endothelial factor165 (VEGF165), potent angiogenic factor, its receptor in synoviocytes. We demonstrated here that neuropilin-1, rather than fms-like tyrosine kinase-1 kinase insert domain-containing receptor, is major...
The purpose of the present study was to examine effect Lycii Radicis Cortex (LRC) and betaine (BT) on immobility neurochemical change in forced swimming test (FST) rat. LRC, BT or fluoxentine administered intraperitoneally Sprague-Dawley rats three times (1, 5 23.5 h) before FST. To investigate antidepressant-like effect, serotonin (5-HT) norepinephrine (NE) were examined hippocampus hypothalamus rats. LRC (100 mg/kg) (30, 100 significantly decreased time increased both 5-HT NE levels...
REarranged during Transfection (RET) fusion genes are detected in approximately 1% of lung adenocarcinomas and known primarily as oncogenic driver factors. Here, we found a novel RET gene, KIAA1217-RET, examined the functional differences RET51 RET9 protein, fused with KIAA1217 cancer progression drug response. resulting from rearrangement chromosome 10, was generated by exon 11 non-small cell patient. Expression this gene led to increased growth invasive properties through activations...
Agaricus blazei (H1 strain) was tested for its anticancer activity using a sarcoma 180 (S180) inoculation model and the changing patterns of splenocyte subsets were examined. Its hot-water extract administered orally to ICR KSN nude mice that inoculated with S180. The growth S180 significantly inhibited in A.blazei treated groups. Pan T cells increased all groups compared controls, even mice. Splenocyte subset changes slightly different between This proved be effective screening antitumor...
Calcineurin is a calcium-activated phosphatase to mediate lymphocyte activation and neuron signaling, but its role in inflammatory arthritis remains largely unknown. In this study, we demonstrate that calcineurin was highly expressed the lining layer, infiltrating leukocytes, endothelial cells of rheumatoid synovium. The basal expression levels were higher cultured synoviocytes patients than those osteoarthritis patients. activity increased by stimulation with proinflammatory cytokines such...
The importance of microglial reactive oxygen species (ROS) signaling in neuroinflammatory processes has been well demonstrated; however, relatively little is known regarding the related mechanisms underlying these processes. Here, we show that ROS-dependent signal pathways govern phagocytosis are highly dependent upon nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox) activation. Specifically, was greatly reduced by both antioxidant and Nox inhibitor treatments...
The diversity of Palaearctic chipmunks was analysed using a set morphological (705 skulls from entire range) and genetic features (144 specimens, cytochrome b gene). Based on the results, we propose three taxa within Eutamias sibiricus. These are E. s. sibiricus, inhabiting Russia, extreme northeast Korea Peninsula, Mongolia, Hokkaido Island, China; barberi, Peninsula except for region, senescens, central China.
Abstract Progesterone treatment has previously been reported to promote the differentiation of glial cells probably through production 5α‐reduced neurosteroids, resulting in enhancement serotonin‐stimulated brain‐derived neurotrophic factor (BDNF) gene expression, which is considered contribute survival, regeneration, and plasticity neuronal brain hence suggested improve mood disorders other symptoms depressive patients. Based on these previous observations, effects histone deacetylase...
Propolis is a natural product made by honeybees that has been widely used in folk medicine with broad spectrum of biological activities. To investigate the antidepressant-like activity propolis extract, CD-1 mice were administered an ethanol extract (50, 100, or 200 mg/kg, p.o.) prior to behavioral test. The extract-treated group showed dose-dependent decrease immobility time FST and tail suspension test without altering locomotor activity. decreased limbic hypothalamic-pituitary-adrenal...
Background: Therapeutic drug monitoring of infliximab (IFX) can improve treatment outcomes; however, the temporal gap between concentration and subsequent availability restricts its practical application. To address this issue, an automated method, AFIAS IFX, was developed to rapidly accurately analyze IFX in blood. The analytical clinical performances method were assessed establish utility. Methods: performance evaluated according Clinical Laboratory Standard Institute guidelines. For...