A5100770739- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Health and Wellbeing Research
- Neural dynamics and brain function
- Education and Learning Interventions
- Stroke Rehabilitation and Recovery
- Aldose Reductase and Taurine
- Bacterial Genetics and Biotechnology
- Single-cell and spatial transcriptomics
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenetic and Muscular Disorders Research
- Exercise and Physiological Responses
- Advanced Memory and Neural Computing
- Neuroscience and Neural Engineering
- Muscle Physiology and Disorders
- Advanced Data Compression Techniques
- Microbial Metabolic Engineering and Bioproduction
- Genetic Associations and Epidemiology
- Advanced biosensing and bioanalysis techniques
- Ion channel regulation and function
- Prostate Cancer Treatment and Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Amyotrophic Lateral Sclerosis Research
- Korean Urban and Social Studies
- Muscle activation and electromyography studies
Johns Hopkins Medicine
2014-2024
Johns Hopkins University
2014-2024
Seoul National University of Science and Technology
2024
Seoul National University
2009-2024
PathAI (United States)
2023-2024
Tsinghua University
2023-2024
Korea Brain Research Institute
2019-2024
Critical Path Institute
2024
Asan Medical Center
2024
Tokyo Institute of Technology
2023
Layer 6 corticothalamic neurons are thought to modulate incoming sensory information via their intracortical axons targeting the major thalamorecipient layer of neocortex, 4, and long-range feedback projections primary thalamic nuclei. However, anatomical reconstructions individual (L6 CT) include examples with axonal processes ramifying within 5, relative input overall population L6 CT layers 4 5 is not well understood. We compared synaptic impact cells on in 5. found that densely ramified...
Neuroligin-1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that required maturation functionally competent excitatory synapses. Despite evidence role neuroligin-1 in specifying synapses, underlying molecular mechanisms physiological consequences may have at mature synapses normal adult animals remain unknown. By silencing endogenous acutely amygdala live behaving animals, we found storage associative fear memory. Subsequent cellular...
The claustrum, a poorly understood subcortical structure located between the cortex and striatum, forms widespread connections with almost all cortical areas, but cellular organization of claustral circuits remains largely unknown. Based primarily on anatomical data, it has been proposed that claustrum integrates activity across sensory modalities. However, extent to which synaptic supports this integration is unclear. Here, we used paired whole-cell recordings optogenetic approaches in...
We compare alternative computing strategies for solving the constrained lasso problem. As its name suggests, extends widely used to handle linear constraints, which allow user incorporate prior information into model. In addition quadratic programming, we employ alternating direction method of multipliers (ADMM) and also derive an efficient solution path algorithm. Through both simulations benchmark data examples, different algorithms provide practical recommendations in terms efficiency...
In the current study, we evaluated factors that increase coronavirus disease (COVID-19) patient death rate by analyzing data from two cohort hospitals. addition, studied whether underlying neurological diseases are risk for death. this retrospective included 103 adult inpatients (aged ≥ 18 years). We differences in demographic between surviving and non-surviving COVID-19 patients. a multivariate logistic analysis, age presence of chronic lung Alzheimer's dementia (AD) were only significant...
The canonical cortical microcircuit has principally been defined by interlaminar excitatory connections among the six layers of neocortex. However, neurons in layer 6 (L6), a whose functional organization is poorly understood, form relatively rare synaptic with other neurons. Here, we show that vast majority parvalbumin inhibitory sublamina within L6 send axons through toward pia. These receive local inputs from both major types and stronger input thalamocortical afferents than do...
The angiopoietin (Ang) family of growth factors includes Ang1, Ang2, Ang3, and Ang4, all which bind to the endothelial receptor tyrosine kinase Tie2. Ang3 (mouse) Ang4 (human) are interspecies orthologs. In experiments with human cell lines, was identified as an antagonist Tie2 agonist However, biological roles unknown. We examined effect recombinant proteins in primary cultured cells vivo mice. Recombinant formed disulfide-linked dimers. (400 ng/mL) markedly increased Akt phosphorylation...
Abstract Sepsis is a devastating condition characterized by systemic inflammatory response. Recently, high mobility group box 1 (HMGB1) was identified as necessary and sufficient mediator of the lethal inflammation caused sepsis. However, despite its clinical importance, mechanism HMGB1 release has remained to be elusive. In this study, we demonstrate that IFN-β-mediated JAK/STAT pathway essential for LPS or Escherichia coli-induced release, which dependent on Toll/IL-1R domain-containing...
Despite considerable evidence for a critical role of neuroligin-1 in the specification excitatory synapses, cellular mechanisms and physiological roles mature neural circuits are poorly understood. In mutant mice deficient neuroligin-1, or adult rats which was depleted, we have found that stabilizes NMDA receptors residing postsynaptic membrane amygdala principal neurons, allows normal range receptor-mediated synaptic transmission. We observed marked decreases currents at afferent inputs to...
Decreased neuronal dendrite branching and plasticity of the hippocampus, a limbic structure implicated in mood disorders, is thought to contribute symptoms depression. However, mechanisms underlying this effect, as well actions antidepressant treatment, remain poorly characterized. Here, we show that hippocampal expression neuritin, an activity-dependent gene regulates plasticity, decreased by chronic unpredictable stress (CUS) treatment reverses effect. We also viral-mediated neuritin...
While the natural niches of soil bacterium Pseudomonas putida are unlikely to include significant amounts free glycerol as a growth substrate, this is genetically equipped with functions required for its metabolism. We have resorted deep sequencing transcripts in glycerol-grown P. KT2440 cells gain an insight into biochemical and regulatory components involved shift between customary C sources (e.g. glucose or succinate) polyol. Transcriptomic results were contrasted key enzymatic activities...
A novel microelectrode modification method is reported for neural electrode engineering with a flake nanostructure (nanoflake). The nanoflake-modified electrodes are fabricated by combining conventional lithography and electrochemical deposition to implement array (MEA) on glass substrate. unique geometrical properties of nanoflake sharp tips valleys studied optical, electrical methods in order verify the advantages using nanoflakes recording devices. vitro stimulation cultured hippocampal...
Cell type-specific changes in neuronal excitability have been proposed to contribute the selective degeneration of corticospinal neurons amyotrophic lateral sclerosis (ALS) and neocortical hyperexcitability, a prominent feature both inherited sporadic variants disease, but mechanisms underlying loss specific cell types ALS are not known. We analyzed physiological properties distinct classes cortical motor cortex hSOD1G93A mice sexes found that they all exhibit increases intrinsic depend on...
Summary P seudomonas putida KT 2440 is a metabolically versatile soil bacterium useful both as model biodegradative organism and host of catalytic activities biotechnological interest. In this report, we present the high‐resolution transcriptome . cultured on different carbon sources revealed by deep sequencing corresponding RNA pools. Examination data from growth substrates that are processed through distinct pathways (glucose, fructose, succinate glycerol) ≥ 20% genome differentially...
Loss of function NFI transcription factors in hypothalamic tanycytes generates diverse subtypes functional neurons.
Glutamate is accumulated in abundance during the early period of experimental hematoma, and activation N-methyl-D-aspartate (NMDA) receptors by glutamate can result an influx calcium neuronal death cases intracerebral hemorrhage (ICH). Memantine, which known to be a moderate-affinity, uncompetitive, NMDA receptor antagonist, was investigated with regard its ability block overstimulation tissue plasminogen activator (tPA)/urokinase (uPA)/matrix metalloproteinase (MMP)-9 modulation ICH....
Light-to-moderate alcohol drinking is associated with a low incidence of cardiovascular disease (CVD) via an elevation high-density lipoproteins-cholesterol (HDL-C), particularly the short-term supplementation alcohol. However, there no information on change in HDL qualities and functionalities between non-drinkers mild drinkers long-term consumption This study analyzed lipid lipoprotein profiles middle-aged Korean female non-drinkers, mild-drinkers, binge-drinkers, who consumed for at least...