This study evaluated the efficacy and safety of 20 mg Cuban policosanol in blood pressure (BP) lipid/lipoprotein parameters healthy Japanese subjects via a placebo-controlled, randomized, double-blinded human trial. After 12 weeks consumption, group showed significantly lower BP, glycated hemoglobin (HbA1c), urea nitrogen (BUN) levels. The also aspartate aminotransferase (AST), alanine (ALT), γ-glutamyl transferase (γ-GTP) levels at week than those 0: A decrease up to 9% (p < 0.05), 17% 15%...

Ozonated sunflower oil (OSO) is renowned for its diverse therapeutic benefits. Nonetheless, the consequences of extended dietary intake OSO have yet to be thoroughly investigated. Herein, effect 2-year supplementation was examined on survivability, obesity, skeletal deformities, swimming behavior, and liver, kidney, ovary, testis function zebrafish. Results showed that zebrafish feed supplemented with 20% (wt/wt) 2 years emerged higher survivability body weight management compared (SO)...

Light-to-moderate alcohol drinking is associated with a low incidence of cardiovascular disease (CVD) via an elevation high-density lipoproteins-cholesterol (HDL-C), particularly the short-term supplementation alcohol. However, there no information on change in HDL qualities and functionalities between non-drinkers mild drinkers long-term consumption This study analyzed lipid lipoprotein profiles middle-aged Korean female non-drinkers, mild-drinkers, binge-drinkers, who consumed for at least...

Policosanols from various sources, such as sugar cane, rice bran, and insects, have been marketed to prevent dyslipidemia, diabetes, hypertension by increasing the blood high-density lipoproteins cholesterol (HDL-C) levels. On other hand, there has no study on how each policosanol influences quality of HDL particles their functionality. Reconstituted (rHDLs) with apolipoprotein (apo) A-I were synthesized using sodium cholate dialysis method compare policosanols in lipoprotein metabolism....

Ozonated sunflower oil (OSO) is well known functional with its antioxidant, antimi-crobial, anti-allergic, and skin-moisturizing properties. However, studies on the effects of OSO high-cholesterol diet (HCD)-induced metabolic disorders have been scarce. In current study, we aimed to determine anti-inflammatory lipid me-tabolism in adult hypercholesterolemic zebrafish embryo. Microinjection (final 2%, 10 nL) into embryos under presence carboxymethyllysine (CML, 500 ng) protected acute embryo...

Ozonated sunflower oil (OSO) is a well-known functional with antioxidant, antimicrobial, anti-allergic, and skin-moisturizing properties. However, studies on the effects of OSO high-cholesterol diet (HCD)-induced metabolic disorders have been scarce. In current study, we aimed to determine anti-inflammatory lipid metabolism in adult hypercholesterolemic zebrafish its embryos. Microinjection (final 2%, 10 nL) into embryos under presence carboxymethyllysine (CML, 500 ng) protected acute embryo...

Background: Hyperinflammation is frequently associated with the chronic pain of autoimmune disease and acute death coronavirus (COVID-19) via a severe cytokine cascade. CIGB-258 (Jusvinza®), an altered peptide ligand 3 kDa from heat shock protein 60 (HSP60), inhibits systemic inflammation storm, but precise mechanism still unknown. Objective: The protective effect against inflammatory stress N-ε-carboxymethyllysine (CML) was tested to provide mechanistic insight. Methods: treated...

Regular exercise, especially aerobic is beneficial for increasing serum high-density lipoprotein-cholesterol (HDL-C) levels in the general population. In addition to HDL-C quantity, exercise enhances HDL functionality, antioxidants, and cholesterol efflux. On other hand, optimal intensity frequency of increase quantity enhance quality middle-aged women need be determined. The current study was designed compare changes among depending on intensity, frequency, duration; participants were...

Obesity and overweight, frequently caused by a lack of exercise, are associated with many metabolic diseases, such as hypertension, diabetes, dyslipidemia. Aerobic exercise effectively increases the high-density lipoproteins-cholesterol (HDL-C) levels alleviates triglyceride (TG) levels. The consumption Cuban policosanol (Raydel®) is also effective in enhancing HDL-C quantity HDL functionality to treat dyslipidemia hypertension. On other hand, no study has examined effects combination...

Ozonated sunflower oil (OSO) has potent antimicrobial effects, making it useful for topical applications to treat various skin diseases. On the other hand, regarding mechanistic insight, antioxidant activity and cytoprotective effects of OSO are relatively less known. The current study compared ability protective on cells embryos against oxidative stress, such as H2O2 oxidized low-density lipoproteins (oxLDL), investigate its potential wound-healing anti-infection. showed radical scavenging...

Ozonated sunflower oil (OSO) is an established therapeutic agent and nutraceutical harboring various values, including antiallergic, derma-protective, broad-spectrum antimicrobial activity. Conversely, the medicinal aspects of OSO for wound healing, tissue regeneration, treatment inflammation in dyslipidemia have yet to be fully elucidated. Herein, a comparative effect (SO) was investigated heal cutaneous regeneration zebrafish impediment by carboxymethyllysine (CML) toxicity, following...

Ozonated sunflower oil (OSO) is an established therapeutic agent and nutraceutical harboring various values, including antiallergic, derma-protective, broad-spectrum antimicrobial activity. Conversely, the medicinal aspects of OSO for wound healing, tissue regeneration, treatment inflammation in dyslipidemia have yet to be fully elucidated. Herein, a comparative effect (SO) was investigated heal cutaneous regeneration zebrafish impediment by carboxymethyllysine (CML) toxicity, following...

CIGB-258 is a 3 kDa altered peptide ligand from heat shock protein (HSP) 60 that exhibits anti-inflammatory activity against the acute toxicity of carboxymethyllysine (CML) with antioxidant and anti-glycation activities via protection high-density lipoprotein (HDL) apolipoprotein A-I (apoA-I). It necessary to test synergistic interaction between apoA-I in reconstituted lipoproteins (rHDL). Several rHDLs were synthesized containing palmitoyloleoyl phosphatidylcholine (POPC), cholesterol,...

Reconstituted high-density lipoproteins (rHDL) containing each policosanol from Cuba (Raydel®), China (Shaanxi Pioneer), and the United States (Lesstanol®) were synthesized to compare physiological properties of depending on sources origin countries. After synthesis with apolipoproteinA-I (apoA-I) into rHDL, all policosanols bound well phospholipid apoA-I form discoidal rHDL. An rHDL Cuban (rHDL-1) showed largest particle size around 83 ± 3 nm, while Chinese (rHDL-2) or American (rHDL-3)...

Recombinant human epidermal growth factor (EGF) has been used to treat adult diabetic foot ulcers and pediatric burns by facilitating wound healing epithelization, especially for elderly patients. Several formulation types of EGF from different expression hosts are clinically available, such as intralesional injection topical application. On the other hand, no study compared in vivo efficacy products directly terms tissue regeneration activity. The present two commercial products,...

수창포의 부위별 건조조건을 달리한 분말의 일반성분, 당 및 클로로필 등을 분석 검토하였다. 각 수분의 함량은 모두 온도가 증가할수록 낮았고, 동결건조를 실시한 시료가 가장 낮았다. 회분함량은 같거나 높아졌으며 동결 건조한 시료의 함량이 조지방과 조단백 건조방법에 따라 유의적 차이가 없었다. 색도 중 잎의 품질특성에 중요한 a*값은 잎상부가 하부에 비하여 a*값이 낮아 품질 면에서 우수하였다. 함량 역시 높았다. 환원 당함량은 뿌리에 높았으며, 특히 40℃ 열풍 총당 건조조건별로 없었으며 총 폴리페놀은 창포의 잎에서 상당히 높은 보였으며, 건조조건에 따라서 유의성 검정 결과 큰 차이는 없었지만 잎이 뿌리보다 나타내었다. 플라보노이드는 뿌리와 고른 분포를 나타내었으나 더 함량을 위의 결과로 품질저하를 막기 위해서는 실시하는 것이 유리할 것으로 생각된다.

Abstract Scanning electron microscopy in ambient conditions (Air‐SEM) was developed recently and has been used mainly for industrial applications. We assessed the potential application of Air‐SEM analysis biological tissues by using rat brain, kidney, human tooth, bone. Hard prepared grinding frozen sections were observed. Basic cytoarchitecture bone tooth identified without heavy metal staining. Kidney tissue routine SEM methodology yielded images comparable to those field emission...

An on-line corrosion rate measurement system was developed using a personal computer, data acquisition board and program, 2-electrode probe. Reliability of the confirmed with through comparison test. With this system, effect sodium nitrite (<TEX>$NaNO_2$</TEX>) as inhibitor were studied on iron aluminum brass that immersed in chloride (NaCl) solution. Corrosion measured based linear polarization resistance method. The rates 1% NaCl solutions to be 0.290 mm per year (mmpy) 0.2134 mmpy,...

Obesity and overweight are associated with many metabolic diseases, such as hypertension, diabetes, dyslipidemia, which closely related to a sedentary lifestyle lack of exercise. Aerobic exercise effectively increases the high-density lipoproteins-cholesterol (HDL-C) levels decreases triglyceride (TG) levels. The consumption Cuban policosanol (Raydel®) is also effective in enhancing HDL-C quantity HDL functionality treat dyslipidemia hypertension. On other hand, no study has examined effects...

Ozonated sunflower oil (OSO) is renowned for its diverse therapeutic benefits. Nonetheless, the consequences of extended dietary intake OSO have yet to be thoroughly investigated. Herein, effect 2-year supplementation was examined on zebrafish survivability, obesity, skeletal deformities, swimming behavior, and liver, kidney, ovary, testis function. Results showed that feed supplemented with 20% (wt/wt) 2 years emerged higher survivability body weight management compared (SO) normal diet...