A5048396680- Cardiovascular Syncope and Autonomic Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Heart Rate Variability and Autonomic Control
- Cancer-related gene regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Sleep and Wakefulness Research
- Angiogenesis and VEGF in Cancer
- Obstructive Sleep Apnea Research
- Cardiac Arrhythmias and Treatments
- Acute Ischemic Stroke Management
- Sympathectomy and Hyperhidrosis Treatments
- Endoplasmic Reticulum Stress and Disease
- Vascular Malformations and Hemangiomas
- Renin-Angiotensin System Studies
- Botulinum Toxin and Related Neurological Disorders
- Restless Legs Syndrome Research
- Long-Term Effects of COVID-19
- Zebrafish Biomedical Research Applications
- Nitric Oxide and Endothelin Effects
- Hereditary Neurological Disorders
- Thermal Regulation in Medicine
- Molecular Sensors and Ion Detection
- Health and Medical Studies
- Peripheral Neuropathies and Disorders
Stanford University
2017-2024
Stanford Medicine
2018-2020
Palo Alto University
2019
Beth Israel Deaconess Medical Center
2016
Harvard University
2016
Medical University of South Carolina
2011-2013
Inha University Hospital
2008
Korea Center for Disease Control and Prevention
2008
Seoul National University Hospital
2005-2008
Seoul National University
2005-2007
Background and Purpose— The rate of nitric oxide (NO) generation from nitrite is linearly dependent on reductions in oxygen pH levels. Recently, nitrite-derived NO has been reported to exert a profound protection against liver heart ischemia-reperfusion injury. In this study, we hypothesized that would be reduced the ischemic brain NO-dependent neuroprotective effects. Methods— Cerebral injury was induced by intraluminal thread occlusion middle cerebral artery adult male rats. Solutions...
Astrocytic glutamate transporter protein, GLT-1 (EAAT2), recovers extracellular and ensures that neurons are protected from excess stimulation. Recently, beta-lactam antibiotics, like ceftriaxone (CTX), were reported to induce the upregulation of GLT-1. Here, we investigated ischemic tolerance induction by CTX in an experimental model focal cerebral ischemia.CTX (200 mg/kg per day, IP) was administered for 5 consecutive days before transient ischemia, which induced intraluminal thread...
Background and Purpose— Understanding on distinct subsets of endothelial progenitor cells may provide insights dysfunction or repair in the acute ischemic event. Recent vitro data have reported colony-forming unit (CFU) outgrowth cell population as a subset cells. In this study, we undertook to validate significance CFU number yield stroke. Methods— Mononuclear were isolated from peripheral blood 75 patients with stroke, 45 chronic 40 age-matched healthy volunteers. numbers counted after...
Failure to recognize symptoms of orthostatic hypotension (OH) may result in falls, syncope, and injuries. The relationship between changes blood pressure symptom occurrence severity is not known. goal the present study was define (1) upright systolic (SBP) (2) fall SBP after tilting patients with OH. We prospectively studied 89 Reported BP values include lowest first 3 minutes tilt change during tilt. Subjects were queried about intolerance while supine testing using Question 1 Orthostatic...
Angiotensin II exerts its central nervous system effects primarily via receptors AT1 and AT2, it participates in the pathogenesis of ischemia AT1. The selective receptor blocker (ARB) is used hypertension treatment, a variety pleiotropic effects, including antioxidative, antiapoptotic, anti-inflammatory effects. In this study, we investigated therapeutic effect ARB telmisartan experimental intracerebral hemorrhage (ICH) normotensive rats. ICH was induced collagenase infusion or autologous...
Glutamate is accumulated in abundance during the early period of experimental hematoma, and activation N-methyl-D-aspartate (NMDA) receptors by glutamate can result an influx calcium neuronal death cases intracerebral hemorrhage (ICH). Memantine, which known to be a moderate-affinity, uncompetitive, NMDA receptor antagonist, was investigated with regard its ability block overstimulation tissue plasminogen activator (tPA)/urokinase (uPA)/matrix metalloproteinase (MMP)-9 modulation ICH....
Livedoid vasculitis is a chronic dermatological problem with an unclear etiology. Clinical findings are petechiae painful ulcers in both lower extremities, which heal to become hyperpigmented and porcelain-white satellite lesions. There only few reported cases of livedoid presenting combination peripheral neuropathy.We report the first case Korean patient mononeuritis multiplex combined vasculitis, was confirmed by electrophysiological pathological studies.Our supports possible...
CASEA 65-year-old cancer survivor presented with widely fluctuating blood pressure (BP) over the past 2 years.At age of 58, he was diagnosed
Orthostatic hypotension is a sustained and pathological drop in blood pressure upon standing. can be due to non-neurogenic conditions or autonomic disorders. Impaired baroreflex-mediated vasoconstriction insufficient release of norepinephrine play key roles the pathophysiology neurogenic orthostatic hypotension. Its common symptoms mainly related inadequate cerebral flow include dizziness, lightheadedness, syncope. It crucial differentiate from For management hypotension, physicians should...