A5078863580- Parkinson's Disease Mechanisms and Treatments
- Sleep and related disorders
- Sleep and Wakefulness Research
- Restless Legs Syndrome Research
- Botulinum Toxin and Related Neurological Disorders
- Neurological disorders and treatments
- Obstructive Sleep Apnea Research
- Olfactory and Sensory Function Studies
- Circadian rhythm and melatonin
- Dementia and Cognitive Impairment Research
- Sleep and Work-Related Fatigue
- Neuroscience of respiration and sleep
- Alcoholism and Thiamine Deficiency
- Balance, Gait, and Falls Prevention
- Non-Invasive Vital Sign Monitoring
- Health, Environment, Cognitive Aging
- Alzheimer's disease research and treatments
- Cerebral Palsy and Movement Disorders
- Metabolism and Genetic Disorders
- Child Nutrition and Feeding Issues
- Autoimmune Neurological Disorders and Treatments
- Voice and Speech Disorders
- Menopause: Health Impacts and Treatments
- Functional Brain Connectivity Studies
- Peripheral Neuropathies and Disorders
Tel Aviv Sourasky Medical Center
2017-2025
Global Brain Health Institute
2019-2025
University of California, San Francisco
2019-2025
Tel Aviv University
2018-2025
University Memory and Aging Center
2021-2025
Stanford University
2022-2024
VA Portland Health Care System
2023
Stanford Medicine
2022
University of California System
2022
The Neurological Institute
2017
Autoimmune encephalitis misdiagnosis can lead to harm.To determine the diseases misdiagnosed as autoimmune and potential reasons for misdiagnosis.This retrospective multicenter study took place from January 1, 2014, December 31, 2020, at subspecialty outpatient clinics including Mayo Clinic (n = 44), University of Oxford 18), Texas Southwestern California, San Francisco 17), Washington in St Louis 6), Utah 4). Inclusion criteria were adults (age ≥18 years) with a prior diagnosis...
Objectives To investigate the objective sleep influencers behind older adult responses to subjective measures, in this case, Pittsburgh Sleep Quality Index (PSQI). Based on previous literature, we hypothesized that SE would be associated with PSQI reported disruption. Furthermore, because SOL increases progressively age and it tends easily remembered by patients, also expected one of main predictors perceived quality elderly. Methods We studied 32 cognitively healthy community-dwelling...
Abstract Study Objectives To examine the association between sleep duration trajectories over 28 years and measures of cognition, gray matter volume, white microstructure. We hypothesize that consistently meeting guidelines recommend at least 7 hours per night will be associated with better greater volumes, higher fractional anisotropy, lower radial diffusivity values. Methods studied 613 participants (age 42.3 ± 5.03 baseline) who self-reported five time points 1985 2013, had cognitive...
Abstract Background Isolated rapid‐eye‐movement sleep behavior disorder (iRBD) is in most cases a prodrome of neurodegenerative synucleinopathies, affecting 1% to 2% middle‐aged and older adults; however, accurate ambulatory diagnostic methods are not available. Questionnaires lack specificity nonclinical populations. Wrist actigraphy can detect characteristic features individuals with RBD; high‐frequency has been rarely used. Objective The aim was develop machine learning classifier using...
Abstract Although neuropsychiatric symptoms are not part of diagnostic criteria for sporadic Creutzfeldt-Jakob disease a few retrospective studies and our clinical experience have suggested they prominent often occur early. The objective study was to assess prospectively the features in sCJD (and their impact on caregivers) compare them with five other neurodegenerative diseases: Alzheimer’s (AD), dementia Lewy bodies (DLB), progressive supranuclear palsy (PSP), behavioral variant...
Abstract Study Objectives Autonomic dysfunction is common across the α-synucleinopathies including isolated RBD (iRBD), however presence, severity and distribution of autonomic as a risk factor for phenoconversion in iRBD remains unclear. We aimed to characterize reflex testing (ART) abnormalities cohort participants with assess them biomarkers. Methods performed ART on 45 individuals evaluated ability components (sympathetic cholinergic, cardiovagal, sympathetic adrenergic) predict using...
Although orthostatic hypotension (OH) can be an early feature of autonomic dysfunction in isolated REM sleep behavior disorder (iRBD), no large-scale studies have examined the frequency OH iRBD. In this study, we prospectively evaluated a large multicenter iRBD cohort.
Background: Validity of the Pittsburgh Sleep Quality Index (PSQI) has not been established for midlife women before menopause, and evidence suggests that two-factor or three-factor models may be more informative than PSQI global score derived from its seven components. We hypothesized factor structure would valid in premenopausal women. Materials Methods: performed a validation study against wrist actigraphy community-based convenience sample 71 healthy (aged 40–50 years). For convergent...
To define the clinical implications of cutaneous phosphorylated α-synuclein (p-syn) and its association with subjective objective measures autonomic impairment features including antidepressant use in isolated rapid eye movement (REM) sleep behavior disorder (iRBD). Twenty-five iRBD patients had quantified neurological cognitive examinations, olfactory testing, questionnaires, function 3 punch skin biopsies (distal thigh, proximal neck). Skin were stained for pan-axonal marker PGP 9.5...
Summary Previous studies indicated that patients with isolated rapid eye movement (REM) sleep behaviour disorder (iRBD) exhibit alterations in spectral electroencephalographic (EEG), spindle, and slow‐wave features. As it is currently unknown how these EEG features evolve over time, this study aimed to evaluate their temporal progression iRBD comparison controls. We included 23 Two polysomnographies (baseline follow‐up) were recorded a mean (standard deviation) interval of 4.0 (2.5) years...
Huntington's disease (HD) is a neurodegenerative characterized by increasing dysphagia as the progresses. Specific characteristics of HD are not well defined.To characterize swallowing disturbances patients, to evaluate feasibility Fiberoptic Endoscopic Evaluation Swallowing (FEES) in assessing and discern relation between FEES findings patients' self-report on symptoms related quality life (SWAL-QOL).A retrospective case series tertiary referral center. All recruited patients underwent Bed...
Retrocollis (RC) is a form of cervical dystonia (CD) that produces patterned, repetitive muscle contractions result in neck extension. We performed review consecutive CD patients seen our Division over 15-year period. Out 399 patients, 59 (14.8%) had features RC. Pain was very frequently reported among ( approximately 80%). RC associated with neuroleptic exposure (20.3%) and history head/neck trauma (23.7%). Of injected botulinum toxin type A, 24.5% excellent, 32.1% moderate, 16.9% mild no...
To describe changes in sleep quality and associated symptoms as women begin menopausal transition compared with premenopausal controls.
Abstract BACKGROUND Neuropsychiatric symptoms (NPSs) are common in neurodegenerative diseases; however, little is known about the prevalence of NPSs Hispanic populations. METHODS Using data from community‐dwelling participants age 65 years and older enrolled 10/66 study ( N = 11,768), we aimed to estimate populations with dementia, parkinsonism, parkinsonism‐dementia (PDD) relative healthy aging. The Inventory Questionnaire (NPI‐Q) was used assess NPSs. RESULTS were highly prevalent disease;...