Julie A. Fields
A5045462803- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Neurobiology of Language and Bilingualism
- Genetic Neurodegenerative Diseases
- Ginkgo biloba and Cashew Applications
- Neurological Disease Mechanisms and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Menopause: Health Impacts and Treatments
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Folate and B Vitamins Research
- Neurological diseases and metabolism
- Glycogen Storage Diseases and Myoclonus
- Frailty in Older Adults
- Attention Deficit Hyperactivity Disorder
- Cerebrovascular and Carotid Artery Diseases
- Cognitive Functions and Memory
- Pregnancy and preeclampsia studies
- Prion Diseases and Protein Misfolding
- Epilepsy research and treatment
WinnMed
2016-2025
Mayo Clinic
2016-2025
Mayo Clinic in Arizona
2015-2024
VIB-UAntwerp Center for Molecular Neurology
2024
University of Antwerp
2024
University of California, Los Angeles
2024
Centre National de la Recherche Scientifique
2020-2024
Mayo Clinic in Florida
2012-2024
Banner Sun Health Research Institute
2024
University of Arizona
2024
Objective: To determine if functional connectivity of the hippocampus is reduced in patients with Alzheimer disease.Design: Functional magnetic resonance imaging was used to investigate coherence signal between and all other regions brain.Participants: Eight probable disease 8 healthy volunteers.Results: Control subjects showed hippocampal diffuse cortical, subcortical, cerebellar sites, while demonstrated markedly connectivity, including an absence frontal lobes. Conclusion:These findings...
Numerous kindreds with familial frontotemporal dementia and/or amyotrophic lateral sclerosis have been linked to chromosome 9, and an expansion of the GGGGCC hexanucleotide repeat in non-coding region 9 open reading frame 72 has recently identified as pathogenic mechanism. We describe key characteristics probands their affected relatives who evaluated at Mayo Clinic Rochester or Florida whom were found. Forty-three 10 DNA available (total 53 subjects) shown carry expansion. Thirty-six (84%)...
Patients with probable dementia Lewy bodies (DLB) often have Alzheimer's disease (AD)-related pathology. Our objective was to determine the pattern of positron emission tomography (PET) tau tracer AV-1451 uptake in patients DLB, compared AD, and its relationship β-amyloid deposition on PET.Consecutive clinically DLB (n = 19) from Mayo Clinic Disease Research Center underwent magnetic resonance imaging, AV-1451, Pittsburgh compound-B (PiB) PET examinations. Age- sex-matched groups AD normal...
Large phenotypically diverse research cohorts with both amyloid and tau PET have only recently come into existence. Our objective was to determine relationships between the bivariate distribution of amyloid-β on established clinical syndromes that are relevant cognitive ageing dementia. All individuals in this study were enrolled Mayo Clinic Study Aging, a longitudinal population-based ageing, or Alzheimer Disease Research Center, recruited from practice. We studied 1343 participants who had...
Abstract BACKGROUND We compared the ability of several plasma biomarkers versus amyloid positron emission tomography (PET) to predict rates memory decline among cognitively unimpaired individuals. METHODS studied 645 Mayo Clinic Study Aging participants. Predictor variables were age, sex, education, apolipoprotein E ( APOE ) ε 4 genotype, PET, and beta (Aβ)42/40, phosphorylated tau (p‐tau)181, neurofilament light (NfL), glial fibrillary acidic protein (GFAP), p‐tau217. The outcome was a...
OBJECTIVES: To determine the effect of a primary care–based collaborative care program for depression on suicidal ideation in older adults. DESIGN: Randomized, controlled trial. SETTING: Eighteen diverse clinics. PARTICIPANTS: One thousand eight hundred one adults aged 60 and with major or dysthymia. INTERVENTION: Participants randomized to had access manager who supported antidepressant medication management prescribed by their physician offered course Problem Solving Treatment Primary Care...
BackgroundHypertension is a risk factor for cerebrovascular disease and cognitive impairment. Women with hypertensive episodes during pregnancy report variable neurocognitive changes within the first decade following affected pregnancy. However, long-term follow-up of these women into their postmenopausal years has not been conducted.ObjectiveThe aim this study was to examine whether history preeclampsia were at increased decline 35-40 after pregnancy.Study DesignWomen identified recruited...
Abstract Introduction We created global rating scoring rules for the CDR ® plus NACC FTLD to detect and track early frontotemporal lobar degeneration (FTLD) conduct clinical trials in FTLD. Methods The was applied 970 sporadic familial participants from baseline visit of Advancing Research Treatment Frontotemporal Lobar Degeneration (ARTFL)/Longitudinal Evaluation Familial Dementia Subjects (LEFFTDS). Each eight domains equally weighed determining score. An interrater reliability study...
It remains controversial whether hormone therapy in recently postmenopausal women modifies the risk of Alzheimer's disease (AD).To investigate effects on amyloid-β deposition women.Participants within 5-36 months past menopause Kronos Early Estrogen Prevention Study, a randomized, double blinded placebo-controlled clinical trial, were randomized to: 1) 0.45 mg/day oral conjugated equine estrogens (CEE); 2) 50μg/day transdermal 17β-estradiol; or 3) placebo pills and patch for four years. Oral...
In a multicenter cohort of probable dementia with Lewy bodies (DLB), we tested the hypothesis that β-amyloid and tau biomarker positivity increases age, which is modified by APOE genotype sex, there are isolated synergistic associations clinical phenotype.We included 417 patients DLB (age 45-93 years, 31% women). Positivity on (A+) (T+) biomarkers was determined CSF β-amyloid1-42 phosphorylated in European Pittsburgh compound B AV-1451 PET Mayo Clinic cohort. Patients were stratified into 4...
At present, no research criteria exist for the diagnosis of prodromal behavioural variant frontotemporal dementia (bvFTD), though early detection is high importance. Thus, we sought to develop and validate a proposed set bvFTD, termed 'mild and/or cognitive impairment in bvFTD' (MBCI-FTD). Participants included 72 participants deemed have bvFTD; this comprised 55 carriers pathogenic mutation known cause lobar degeneration, 17 individuals with autopsy-confirmed degeneration. All had mild...
Frontotemporal dementia (FTD) therapy development is hamstrung by a lack of susceptibility, diagnostic, and prognostic biomarkers. Blood neurofilament light (NfL) shows promise as biomarker, but studies have largely focused only on core FTD syndromes, often grouping patients with different diagnoses. To expedite the clinical translation NfL, we avail ARTFL LEFFTDS Longitudinal Lobar Degeneration (ALLFTD) study resources conduct comprehensive investigation plasma NfL across syndromes in...
Rapid eye movement (REM) sleep behavior disorder (RBD) is widely considered a prodromal synucleinopathy, as most with RBD develop overt synucleinopathy within ~10 years. Accordingly, offers an opportunity to test potential treatments at the earliest stages of synucleinopathy. The North American Prodromal Synucleinopathy (NAPS) Consortium has created multisite participant, primarily clinic-based cohort better understand characteristics diagnosis, and in future work, identify predictors...
Abstract INTRODUCTION Patients with dementia Lewy bodies (DLB) may have Alzheimers disease (AD) pathology that can be detected by plasma biomarkers. Our objective was to evaluate biomarkers of AD and their association positron emission tomography (PET) amyloid tau deposition in the continuum DLB, starting from prodromal stages disease. METHODS The cohort included patients isolated rapid eye movement (REM) sleep behavior disorder (iRBD), mild cognitive impairment (MCI‐LB), or a concurrent...
Importance Frontotemporal lobar degeneration (FTLD) is relatively rare, behavioral and motor symptoms increase travel burden, standard neuropsychological tests are not sensitive to early-stage disease. Remote smartphone-based cognitive assessments could mitigate these barriers trial recruitment success, but no such tools validated for FTLD. Objective To evaluate the reliability validity of measures remote FTLD evaluations. Design, Setting, Participants In this cohort study conducted from...
Abstract Predominant limbic degeneration has been associated with various underlying aetiologies and an older age, predominant impairment of episodic memory slow clinical progression. However, the neurological syndrome is not defined. This endeavour critical to distinguish such a from those originating neocortical degeneration, which may differ in aetiology, disease course therapeutic needs. We propose set criteria for limbic-predominant amnestic neurodegenerative that highly age-related...
Background Mayo Test Drive (MTD): Development through Rapid Iteration, Validation and Expansion, is a web-based remote cognitive assessment platform for self-administered neuropsychological measures with previously demonstrated validity reliability. We examined the usability of MTD hypothesized that completion rates would be greater than 90%. explored whether participation differed by status demographic factors.
Previous research suggests that lexical and semantic verbal fluency are differentially sensitive to the effects of cortical subcortical dementias, but little is known about action performance in dementias. The present study compared lexical, semantic, groups patients with Parkinson's disease (PD) without dementia an elderly control group. Findings revealed interaction between type subject Although demented PD (PDD) group performed significantly more poorly than their non-demented...
Few studies have been published regarding the neuropsychological characteristics of patients with essential tremor (ET), but preliminary findings suggest that mild attentional and executive dysfunction accompany disorder. A consecutive series 101 ET referred for thalamotomy and/or thalamic deep brain stimulation candidacy work-up also underwent evaluation. Average test scores were calculated, along proportions subjects whose fell within or more than one SD above below mean (using...