A5026717714- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Amyotrophic Lateral Sclerosis Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Functional Brain Connectivity Studies
- S100 Proteins and Annexins
- Tryptophan and brain disorders
- Lanthanide and Transition Metal Complexes
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Neurological Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neurological diseases and metabolism
- Hereditary Neurological Disorders
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related cognitive impairment studies
- Health Systems, Economic Evaluations, Quality of Life
- Genetic Neurodegenerative Diseases
- Cerebral Venous Sinus Thrombosis
- Neuroscience and Neuropharmacology Research
- Neurobiology of Language and Bilingualism
- Computational Drug Discovery Methods
Houston Methodist
2016-2025
Cornell University
2016-2025
Methodist Hospital
2015-2025
Mayo Clinic in Arizona
2025
Johns Hopkins University
2025
Vanderbilt University Medical Center
2025
Weill Cornell Medicine
2018-2024
VIB-UAntwerp Center for Molecular Neurology
2024
University of Antwerp
2024
University of California, Los Angeles
2024
The most rostral portion of the human temporal cortex, pole (TP), has been described as "enigmatic" because its functional neuroanatomy remains unclear. Comparative anatomy studies are only partially helpful, TP is larger and cytoarchitectonically more complex than in nonhuman primates. Considered by Brodmann a single area (BA 38), recently parceled into an array cytoarchitectonic subfields. In order to clarify connectivity subregions TP, we undertook study 172 healthy adults using...
At present, no research criteria exist for the diagnosis of prodromal behavioural variant frontotemporal dementia (bvFTD), though early detection is high importance. Thus, we sought to develop and validate a proposed set bvFTD, termed 'mild and/or cognitive impairment in bvFTD' (MBCI-FTD). Participants included 72 participants deemed have bvFTD; this comprised 55 carriers pathogenic mutation known cause lobar degeneration, 17 individuals with autopsy-confirmed degeneration. All had mild...
Inflammation is a significant component of Alzheimer's disease pathology. While neuroprotective microglia are important for containment/clearance Amyloid plaques and maintaining neuronal survival, Alzheimer inflammatory may play detrimental role by eliciting tau pathogenesis accelerating neurotoxicity. Regulatory T cells have been shown to suppress microglia-mediated inflammation. However, the regulatory in ameliorating proinflammatory immune response requires further investigation....
Frontotemporal dementia (FTD) therapy development is hamstrung by a lack of susceptibility, diagnostic, and prognostic biomarkers. Blood neurofilament light (NfL) shows promise as biomarker, but studies have largely focused only on core FTD syndromes, often grouping patients with different diagnoses. To expedite the clinical translation NfL, we avail ARTFL LEFFTDS Longitudinal Lobar Degeneration (ALLFTD) study resources conduct comprehensive investigation plasma NfL across syndromes in...
Brain inflammation, with an increased density of microglia and macrophages, is important component Alzheimer's disease a potential therapeutic target. However, it incompletely characterized, particularly in patients whose begins before the age 65 years and, thus, have few co-pathologies. Inflammation has been usefully imaged translocator protein (TSPO) PET, but most inflammation PET tracers cannot image subjects low-binder TSPO rs6971 genotype. In development, participants any genotype can...
Importance Frontotemporal lobar degeneration (FTLD) is relatively rare, behavioral and motor symptoms increase travel burden, standard neuropsychological tests are not sensitive to early-stage disease. Remote smartphone-based cognitive assessments could mitigate these barriers trial recruitment success, but no such tools validated for FTLD. Objective To evaluate the reliability validity of measures remote FTLD evaluations. Design, Setting, Participants In this cohort study conducted from...
Abstract INTRODUCTION Higher male prevalence in sporadic behavioral variant frontotemporal dementia (bvFTD) has been reported. We hypothesized differences phenotypes between genetic and bvFTD females resulting underdiagnosis of females. METHODS included patients from two multicenter cohorts. compared cognitive symptoms, gray matter volumes, cases each sex. RESULTS Females with showed worse compulsive behavior ( p = 0.026) language impairments 0.024) to n 152). Genetic had smaller volumes...
Background and Purpose— The boundary between vascular dementia Alzheimer disease (AD) continues to be unclear. Some posit that gradually progressive dementia, as with small vessel disease, is simply plus AD. Because AD presents a characteristic pattern on fluorodeoxyglucose positron emission tomography, we sought determine whether the of resembled more or in nondemented patients severe microvascular brain disease. Methods— Vascular were selected basis confluent white matter lesions both...
<h3>BACKGROUND AND PURPOSE:</h3> The “ears of the lynx” MR imaging sign has been described in case reports hereditary spastic paraplegia with a thin corpus callosum, mostly associated mutations <i>spatacsin vesicle trafficking associated</i> gene, causing Spastic Paraplegia type 11 (SPG11). This corresponds to long T1 and T2 values forceps minor which appears hyperintense on FLAIR hypointense T1-weighted images. Our purpose was determine sensitivity specificity ears lynx for genetic cases...
Neuroinflammation is a hallmark of neurodegenerative disease and significant component the pathology Alzheimer’s (AD). Patients present with extensive microgliosis along elevated pro-inflammatory signaling in central nervous system periphery. However, role peripheral myeloid cells mediating influencing AD pathogenesis remains unresolved. Peripheral were isolated from blood patients prodromal (n = 44), mild dementia 25), moderate/severe 28), age-matched controls 54). evaluated clinic for...
As currently used, the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS-Cog) has low sensitivity for measuring disease progression in clinical trials. A major reason behind is its sub-optimal scoring methodology, which can be improved to obtain better sensitivity.Using item response theory, we developed a new methodology (ADAS-CogIRT) ADAS-Cog, addresses several limitations of current methodology. The ADAS-CogIRT was evaluated using trial simulations as well negative trial, had...
<sup>18</sup>F-GE180 is a third-generation PET tracer for quantifying the translocator protein (TSPO), biomarker inflammation. The aim of this study was to perform head-to-head comparison and well-established TSPO <sup>11</sup>C-PBR28 by scanning with both tracers during same day in subjects. <b>Methods:</b> Five subjects underwent 90-min scan morning afternoon. A metabolite-corrected arterial input function obtained each subject tracers, brain uptake quantified 2-tissue-compartment model....
Abstract Despite epidemiological and genetic data linking semantic dementia to inflammation, the topography of neuroinflammation in dementia, also known as variant primary progressive aphasia, remains unclear. The pathology starts at tip left temporal lobe where, addition cortical atrophy, a strong signal appears with tau PET tracer 18F-flortaucipir, even though disease is not typically associated but TDP-43 protein aggregates. Here, we characterized inflammation aphasia using...
Background: Understanding research participants’ responses to learning Alzheimer’s disease (AD) risk information is important inform clinical implementation of precision diagnostics given rapid advances in modifying therapies. Objective: We assessed perspectives on the meaning their amyloid positron emission tomography (PET) imaging results for health, self-efficacy understand results, psychological impact experience receiving from team, and interest genetic testing AD risk. Methods:...
Background Measuring systemic inflammatory markers may improve clinical prognosis and help identify targetable pathways for treatment in patients with autosomal dominant forms of frontotemporal lobar degeneration (FTLD). Methods We measured plasma concentrations IL-6, TNFα YKL-40 pathogenic variant carriers ( MAPT, C9orf72, GRN ) non-carrier family members enrolled the ARTFL-LEFFTDS Longitudinal Frontotemporal Lobar Degeneration consortium. evaluated associations between baseline...
Abstract Background Therapeutic development for frontotemporal dementia (FTD) is hindered by the lack of biomarkers that inform susceptibility/risk, prognosis, and underlying causative pathology. Blood glial fibrillary acidic protein (GFAP) has garnered attention as a FTD biomarker. However, investigations GFAP in have been hampered symptomatic histopathologic heterogeneity small cohort sizes contributing to inconsistent findings. Therefore, we evaluated plasma biomarker compared its...
ABSTRACT BACKGROUND AND PURPOSE A thin corpus callosum on magnetic resonance imaging (MRI) characterizes a type of autosomal recessive disorder with progressive spastic paraparesis and cognitive impairment. Known as Hereditary Spastic Paraparesis Thin Corpus Callosum (HSP‐TCC), it has been associated mutations the SPG11 gene. No other specific MRI findings have reported. METHODS We studied four patients from three families HSP‐TCC who had identified causal in RESULTS In all individuals...
Neuronal loss in Alzheimer's disease, a better correlate of cognitive impairment than amyloid deposition, is currently gauged by the degree regional atrophy. However, functional markers, such as GABA(A) receptor density, marker neuronal integrity, could be more sensitive. In post-mortem hippocampus, messenger RNA expression reduced even mild impairment. We measured whole-brain binding potential vivo using [(11)C]-flumazenil positron emission tomography and compared with metabolic volumetric...