A5084625117- Medical Imaging Techniques and Applications
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Radiopharmaceutical Chemistry and Applications
- Advanced X-ray and CT Imaging
- Radiation Therapy and Dosimetry
- Radiation Dose and Imaging
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Glioma Diagnosis and Treatment
- Virus-based gene therapy research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cardiovascular Function and Risk Factors
- Alzheimer's disease research and treatments
- Neural and Behavioral Psychology Studies
- Radioactive Decay and Measurement Techniques
- Cancer Treatment and Pharmacology
- Medical Imaging and Pathology Studies
- Dementia and Cognitive Impairment Research
- Neurotransmitter Receptor Influence on Behavior
Clinica Universidad de Navarra
2016-2025
Navarre Institute of Health Research
2015-2021
Bellvitge University Hospital
2018
Institut d'Investigació Biomédica de Bellvitge
2018
Institut Català d'Oncologia
2018
Universidad de Navarra
2003-2017
Siemens Healthcare (Germany)
2013
Instituto de Salud Carlos III
2010-2013
Biomedical Research Networking Center on Neurodegenerative Diseases
2010-2012
Centro de Investigación Biomédica en Red
2010
We used functional brain imaging with positron emission tomography (PET)-H<sub>2</sub><sup>15</sup>O to study a remarkable neurophysiological finding in the normal brain. Auditory stimulation at various frequencies gamma range elicits steady-state scalp electroencephalographic (EEG) response that peaks amplitude 40 Hz, smaller amplitudes lower and higher frequencies. confirmed this 28 healthy subjects, each studied monaural trains of stimuli 12 different rates (12, 20, 30, 32, 35, 37.5, 40,...
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Background and Purpose— The boundary between vascular dementia Alzheimer disease (AD) continues to be unclear. Some posit that gradually progressive dementia, as with small vessel disease, is simply plus AD. Because AD presents a characteristic pattern on fluorodeoxyglucose positron emission tomography, we sought determine whether the of resembled more or in nondemented patients severe microvascular brain disease. Methods— Vascular were selected basis confluent white matter lesions both...
The aim of this study was to assess the physical performance a new PET/CT system, Discovery IQ with 5-ring detector blocks. <b>Methods:</b> Performance measured using National Electrical Manufacturers Association NU2-2012 methodology. Image quality extended by accounting for different acquisition parameters (lesion-to-background ratios [8:1, 4:1, and 2:1] times) reconstruction algorithms (VUE-point HD [VPHD], VPHD point-spread-function modeling [VPHD-S], Q.Clear). Tomographic also assessed...
The aim of this study was to retrospectively evaluate the patient effective dose (ED) for different PET/CT procedures performed with a variety PET radiopharmaceutical compounds. studies 210 patients were reviewed including Torso (n = 123), Whole body (WB) 36), Head and Neck Tumor (HNT) 10), Brain 41) protocols 18FDG 170), 11C-CHOL 18FDOPA 11C-MET 18F-florbetapir 10). ED calculated using conversion factors applied radiotracer activity CT dose-length product. Total (mean ± SD) Torso-11C-CHOL,...
Accuracy in the quantification of SUV is a critical point PET because proper tumor uptake essential for therapy monitoring and prognosis evaluation. Recent advances such as time-of-flight (TOF) point-spread-function (PSF) reconstructions have dramatically improved detectability. However, first experiences with these techniques shown consistent tendency to measure markedly high values, bewildering nuclear medicine physicians referring clinicians.We investigated different reconstruction...
We have investigated dual-time-point <sup>18</sup>F-FDG PET for the detection and delineation of high-grade brain tumors using quantitative criteria applied on a voxel basis. <b>Methods:</b> Twenty-five patients with suspected inconclusive MRI findings underwent <sup>11</sup>C-methionine PET. Images from each subject were registered spatially normalized. Parametric maps standardized uptake value (SUV) tumor–to–normal gray matter (TN) ratio image obtained. Tumor diagnosis was evaluated...
Purpose: An improved method for multichannel dosimetry is presented. This explicitly takes into account the information provided by unexposed image of film. Methods: The calculates dose applying a couple perturbations to scanned dose, one dependent and other independent on color channel. has been compared with previous two single channel methods (red green) against measurements using different tests: first, five percentage depth profiles covering wide range doses; second, map perpendicular...
The aim of this study was to evaluate the behavior a penalized-likelihood image reconstruction method (Q.Clear) under different count statistics and lesion-to-background ratios (LBR) on BGO scanner, in order obtain an optimum penalization factor (β value) optimize for acquisition protocols clinical goals.Both phantom patient images were evaluated. Data from quality acquired using Lesion-to-Background times. Then, each series reconstructed β values between 50 500, at intervals 50. Hot cold...
Neuronal loss in Alzheimer's disease, a better correlate of cognitive impairment than amyloid deposition, is currently gauged by the degree regional atrophy. However, functional markers, such as GABA(A) receptor density, marker neuronal integrity, could be more sensitive. In post-mortem hippocampus, messenger RNA expression reduced even mild impairment. We measured whole-brain binding potential vivo using [(11)C]-flumazenil positron emission tomography and compared with metabolic volumetric...
Abstract The present work investigates the influence of different biological and physical parameters on image quality (IQ) perception abdominal area in a modern PET scanner, using new reconstruction algorithms testing utility radiomics approach. Scans 112 patients were retrospectively included. Images reconstructed both OSEM + PSF BSRM methods, IQ region was subjectively evaluated. First, 22 related obtained (including count rate or mixed parameters) compared to subjective scores by means...
Progressive nonfluent aphasia (PNFA) is an early stage of frontotemporal degeneration. We identified a novel Cys521Tyr progranulin gene variant in PNFA family that potentially disrupts disulphide bridging causing protein misfolding. To identify neurodegeneration changes, we performed neuropsychological and neuroimaging studies 6 members (MRI [magnetic resonance imaging], fMRI [functional MRI], 18f-fluorodeoxygenlucose positron emission tomography, including 4 mutation carriers, 9 unrelated...
90Y-microspheres are widely used for the radioembolization of metastatic liver cancer or hepatocellular carcinoma and there is a growing interest imaging with PET. The aim this study to evaluate performance current generation PET/CT scanner 90Y optimize PET protocol improve assessment quantification 90Y-microsphere biodistribution after radioembolization.Data were acquired on Biograph mCT-TrueV time flight (TOF) point spread function (PSF) modeling. Spatial resolution was measured source....
In hadron therapy, out-of-field doses, which may in the long-term cause secondary cancers, are mostly due to neutrons. Very recently, 4He and 16O beams have been added protons 12C ions for clinical therapy. The focus of this article is compare neutron doses produced by protons, 4He, 12C, ion beams. Ambient dose equivalent, H*(10), measurements were performed, with five types rem counters, field four primary impinging on a water phantom. This experiment was performed at Heidelberg Ion Beam...
Abstract Deficits in sustained attention have been frequently described schizophrenia. The neuroanatomical basis reported previously included altered levels of activation cingulate and prefrontal cortex, but the contribution further regions remains unclear. We explored full neuroanatomy underlying attentional deficits observed naïve schizophrenics compared with controls. Participants 10 controls 11 patients. experimental design rest, auditory stimulation using clicks, two counting tasks....
Molecular imaging of breast cancer has undoubtedly permitted a substantial development the overall diagnostic accuracy this malignancy in last years. Accurate tumour staging, design individually suited therapies, response evaluation, early detection recurrence and distant lesions have also evolved parallel with novel molecular approaches. In context, positron emission tomography (PET) can be probably seen as most interesting technology straightforward clinical application for such purposes....