A5089312897- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Parkinson's Disease Mechanisms and Treatments
- Autopsy Techniques and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- COVID-19 and healthcare impacts
- Traumatic Brain Injury Research
- Long-Term Effects of COVID-19
- Child Abuse and Related Trauma
- Amyotrophic Lateral Sclerosis Research
- COVID-19 Clinical Research Studies
- Advanced Neuroimaging Techniques and Applications
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Spinal Cord Injury Research
- Cerebrovascular and Carotid Artery Diseases
- Ginkgo biloba and Cashew Applications
- Traumatic Ocular and Foreign Body Injuries
- Forensic Entomology and Diptera Studies
- Neurological Disease Mechanisms and Treatments
- Injury Epidemiology and Prevention
- Trauma and Emergency Care Studies
- Clinical Laboratory Practices and Quality Control
- Lysosomal Storage Disorders Research
Mayo Clinic
2012-2025
Mayo Clinic in Arizona
2014-2025
University of Minnesota Rochester
2012-2025
WinnMed
2012-2024
Mayo Clinic in Florida
2014-2024
University of Calgary
2024
Boston University
2024
Jacksonville College
2023
University Hospital and Clinics
2020
Yokohama City University
2020
Chronic traumatic encephalopathy is a progressive tauopathy that occurs as consequence of repetitive mild brain injury.We analysed post-mortem brains obtained from cohort 85 subjects with histories injury and found evidence chronic in 68 subjects: all males, ranging age 17 to 98 years (mean 59.5 years), including 64 athletes, 21 military veterans (86% whom were also athletes) one individual who engaged self-injurious head banging behaviour.Eighteen age-and gender-matched individuals without...
We report the neuropathological findings of a patient who died from complications COVID-19. The decedent was initially hospitalized for surgical management underlying coronary artery disease. He developed post-operative and evaluated with chest imaging studies. computed tomography (CT) results were indicative COVID-19 he subsequently tested SARS-CoV-2, which positive. His condition worsened after more than 2 weeks hospitalization aggressive treatment. autopsy revealed range lesions, features...
Only a handful of studies have investigated the nature, functional significance, and course white matter abnormalities associated with mild traumatic brain injury (mTBI) during semi-acute stage injury. The present study used diffusion tensor imaging (DTI) to investigate integrity compared accuracy traditional anatomic scans, neuropsychological testing, DTI for objectively classifying mTBI patients from controls.Twenty-two (mean = 12 days postinjury), 21 matched healthy controls, larger...
Abstract Introduction Comparison of tau (flortaucipir) positron emission tomography (FTP‐PET) to autopsy is important demonstrate the relationship FTP‐PET neuropathologic findings. Methods Autopsies were performed on 26 participants who had antemortem FTP‐PET. standardized uptake value ratios (SUVRs) compared diagnoses and Braak tangle stage. Quantitative burden was regional signal. Results Participants with stages IV or greater elevated in Alzheimer's disease. An SUVR cut point 1.29...
Abstract Chronic traumatic encephalopathy is a debilitating neurodegenerative disorder associated with repetitive brain injuries often sustained through prior contact sport participation. The frequency of this in diverse population, including amateur athletes, unknown. Primary historical obituary and yearbook records were queried for 2566 autopsy cases the Mayo Clinic Tissue Registry resulting identification 300 former athletes 450 non‐athletes. In these cases, neocortical tissue was...
<h3>Objective</h3> To determine whether Lewy body disease subgroups have different clinical profiles. <h3>Methods</h3> Participants had dementia, autopsy-confirmed transitional or diffuse (TLBD DLBD) (n = 244), Alzheimer (AD) 210), and were seen at least twice (mean follow-up 6.2 ± 3.8 years). TLBD DLBD groups partitioned based on the presence absence of neocortical neurofibrillary tangles using Braak staging. Four AD compared features, dementia trajectory, onset latency probable with bodies...
Updated criteria for the clinical-MRI diagnosis of cerebral amyloid angiopathy (CAA) have recently been proposed. However, their performance in individuals without symptomatic intracerebral hemorrhage (ICH) presentations is less defined. We aimed to assess diagnostic Boston version 2.0 CAA a cohort ranging from cognitively normal dementia community and memory clinic settings.
Abstract Predominant limbic degeneration has been associated with various underlying aetiologies and an older age, predominant impairment of episodic memory slow clinical progression. However, the neurological syndrome is not defined. This endeavour critical to distinguish such a from those originating neocortical degeneration, which may differ in aetiology, disease course therapeutic needs. We propose set criteria for limbic-predominant amnestic neurodegenerative that highly age-related...
To determine the contribution of heroin, prescription opioids, cocaine and alcohol/drug combinations to total overdose death rate identify changes in drug patterns among New Mexico subpopulations.We analyzed medical examiner data for all unintentional deaths during 1990-2005. Age-adjusted rates were calculated by sex race/ethnicity; we modeled overall adjusting age region.The increased from 5.6 per 100 000 1990 15.5 2005. Deaths caused together ranged 89% 98% total. Heroin most 1990-2005,...
Corticobasal syndrome (CBS) is a clinical phenotype characterized by asymmetric parkinsonism, rigidity, myoclonus, and apraxia. Originally believed secondary to corticobasal degeneration (CBD), mounting clinicopathologic studies have revealed heterogenous neuropathologies. The objectives of this study were determine the pathologic heterogeneity CBS, clinicoradiologic findings associated with different underlying pathologies causing positive predictive value (PPV) current diagnostic criteria...
Factors associated with clinical heterogeneity in Alzheimer disease (AD) lay along a continuum hypothesized to associate tangle distribution and are relevant for understanding glial activation considerations therapeutic advancement.
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Abstract Introduction We examined the temporal sequence of core features in probable dementia with Lewy bodies (DLB). Methods In 488 patients DLB, onset each feature and time to diagnosis was determined for men women, a pathologic subgroup (n = 209). Results REM sleep behavior disorder (RBD) developed before other women. Men were more likely have RBD diagnosed DLB earlier than Visual hallucinations after men, but they appeared concurrently fluctuations parkinsonism. Women older cognitively...
Abstract Multi-compartment modelling of white matter microstructure using Neurite Orientation Dispersion and Density Imaging (NODDI) can provide information on health through neurite density index free water measures. We hypothesized that cerebrovascular disease, Alzheimer’s TDP-43 proteinopathy would be associated with distinct NODDI readouts damage which informative for identifying the substrate cognitive impairment. identified two independent cohorts multi-shell diffusion MRI, amyloid tau...
Abstract Mild cognitive impairment with the core clinical features of dementia Lewy bodies is recognized as a prodromal stage bodies. Although grey matter atrophy has been demonstrated in bodies, longitudinal rates during progression to probable are unknown. We investigated regional patterns cross-sectional and including those who progressed Patients mild at least one feature (mean age = 70.5; 95% male), were enrolled Mayo Clinic Alzheimer’s Disease Research Center followed for two...
Abstract Background Advances in ultrasensitive detection of phosphorylated tau (p-tau) plasma has enabled the use blood tests to measure Alzheimer’s disease (AD) biomarker changes. Examination postmortem brains participants with antemortem p-tau levels remains critical understanding comorbid and AD-specific contribution these Methods We analyzed 35 population-based Mayo Clinic Study Aging at threonine 181 217 (p-tau181, p-tau217) available within 3 years death. Autopsied included cognitively...
Digital pathology (DP) has transformative potential, especially for Alzheimer disease and related disorders. However, infrastructure barriers may limit adoption. To provide benchmarks insights into implementation barriers, a survey was conducted in 2019 within National Institutes of Health's Alzheimer's Disease Centers (ADCs). Questions covered infrastructure, funding sources, data management to digital pathology. Of the 35 ADCs which sent, 33 responded. Most respondents (81%) stated that...
The neuropathologist involved in forensic work is not uncommonly confronted with a case which there no or only limited history or, if available, the information uncertain often conflicting. In recent years immunohistochemical stain β‐amyloid precursor protein (β‐APP) has been used to assess extent of axonal injury variety pathological processes but practice greatest utility assessment traumatic brain injury. Diffuse (TAI) humans demonstrated by β‐APP immunoreactivity patients surviving at...
Sudden unexpected death is typically diagnosed in infants, children, teenagers, and young adults following completion of an autopsy that fails to identify a cause or when suggests potentially genetic individual less than 40, such as cardiomyopathy aneurysm. Such deaths may be result abnormalities are unable by gross microscopic inspection, but detectable molecular studies. Unfortunately, the ability perform postmortem testing frequently hindered lack appropriate specimen autopsy. This paper...
Background: Phosphorylated cytoplasmic tau inclusions correlate with and precede cognitive deficits in Alzheimer’s disease (AD). However, pathological accumulation relationships to synaptic changes remain unclear. Objective: To address this, we examined postmortem brain from 50 individuals the full spectrum of AD (clinically neuropathologically). Total tau, pTau231, AMPA GluR1 were compared across two regions (entorhinal middle frontal cortices), as well clinically stratified groups...
The X-linked McLeod neuroacanthocytosis syndrome (MLS) has originally been denoted as 'benign' myopathy. We assessed the clinical findings and muscle pathology in eponymous index patient, Hugh McLeod, nine additional MLS patients. Only one patient had manifested with neuromuscular symptoms. During a mean follow-up of 15 years, however, eight patients including initial showed elevated skeletal creatine kinase levels ranging from 300 to 3000 U/L, developed weakness atrophy. Two disabling leg...
To quantify the impact of severe acute respiratory syndrome coronavirus 2 pandemic on emergency department volumes and patient presentations evaluate changes in community mortality for purpose characterizing new patterns care use.This is an observational cross-sectional study using electronic health records visits integrated multihospital system with academic practices across 4 states between March 17 April 21, 2019, February 9 2020. We compared numbers proportions common critical chief...